Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
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CTLA-4 SNPs (CT60A/G, -1722T/C, -1661G/A, and -318C/T) and Systemic Lupus Erythematosus: A Meta-Analysis
ABSTRACT
In this meta-analysis, we investigated the association between CTLA-4 polymorphisms (CT60A/G, -1722T/C, -1661G/A, and -318C/T) and SLE susceptibility. Data were extracted independently by two reviewers. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in fixed or random effects models. Seventeen studies involving of 3931 cases and 4619 controls were identified. Significant association of promoter -1722T/C polymorphism and SLE was observed for TT vs. CC (OR=1.63, 95% CI 1.63-2. 30, P<0.05) in the overall study population and in the Asians subgroups (OR=2. 18, 95% CI 1.70−2. 81, P<0.05); the OR for the allele T vs. C in Asians was 1.66 (95% CI 1.33−2. 07, P<0.05). For the CT60A/G polymorphism, significant association was observed for AA vs. AG (OR=0.64, 95% CI 0.46−0.88, P<0.05) in Asians. These results suggest that -1722T/C and CT60A/G polymorphisms in CTLA-4 are associated with SLE, particularly in Asians.
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