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Plasma Medicine

Published 4 issues per year

ISSN Print: 1947-5764

ISSN Online: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Effect of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells

Volume 4, Issue 1-4, 2014, pp. 49-56
DOI: 10.1615/PlasmaMed.2014011935
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ABSTRACT

Medical applications of nonequilibrium atmospheric pressure plasma (NEAPP) have been reported in cancer therapy. Cells with tumorigenic potential are limited to a small population, called cancer-initiating cells (CICs), which are usually expressing aldehyde dehydrogenate (ALDH) in a high level. CICs are believed to cause recurrence or metastasis due to their resistance to apoptosis. Here, we examined the effect of NEAPP on CICs using human uterine endometrioid adenocarcinoma cells and poorly differentiated human gastric carcinoma cells. When treated with NEAPP, ALDH-high cells fell into apoptosis in a comparable level to ALDH-low cells. These results suggested that NEAPP treatment was effective not only on non-CICs but also on CICs. NEAPP might become a new therapeutic approach to CICs.

CITED BY
  1. Ikeda Jun-Ichiro, Tsuruta Yoko, Nojima Satoshi, Sakakita Hajime, Hori Masaru, Ikehara Yuzuru, Anti-Cancer Effects of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells in Human Endometrioid Adenocarcinoma Cells, Plasma Processes and Polymers, 12, 12, 2015. Crossref

  2. Ikeda Jun-ichiro, Tanaka Hiromasa, Ishikawa Kenji, Sakakita Hajime, Ikehara Yuzuru, Hori Masaru, Plasma-activated medium (PAM) kills human cancer-initiating cells, Pathology International, 68, 1, 2018. Crossref

  3. Dai Xiaofeng, Bazaka Kateryna, Richard Derek J., Thompson Erik (Rik) W., Ostrikov Kostya (Ken), The Emerging Role of Gas Plasma in Oncotherapy, Trends in Biotechnology, 36, 11, 2018. Crossref

  4. Reactive Oxygen Species in Plasma Medical Science (PAM and Cancer Therapy), in Plasma Medical Science, 2019. Crossref

  5. Dai Xiaofeng, Zhang Zhifa, Zhang Jianying, Ostrikov Kostya (Ken), Dosing: The key to precision plasma oncology, Plasma Processes and Polymers, 17, 10, 2020. Crossref

  6. Zubor Pavol, Wang Yun, Liskova Alena, Samec Marek, Koklesova Lenka, Dankova Zuzana, Dørum Anne, Kajo Karol, Dvorska Dana, Lucansky Vincent, Malicherova Bibiana, Kasubova Ivana, Bujnak Jan, Mlyncek Milos, Dussan Carlos Alberto, Kubatka Peter, Büsselberg Dietrich, Golubnitschaja Olga, Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology, International Journal of Molecular Sciences, 21, 21, 2020. Crossref

  7. Alizadeh Elahe, Ptasińska Sylwia, Recent Advances in Plasma-Based Cancer Treatments: Approaching Clinical Translation through an Intracellular View, Biophysica, 1, 1, 2021. Crossref

  8. Mateu-Sanz Miguel, Tornín Juan, Ginebra Maria-Pau, Canal Cristina, Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy, Journal of Clinical Medicine, 10, 4, 2021. Crossref

  9. Wada Naoki, Ikeda Jun-ichiro, Tanaka Hiromasa, Sakakita Hajime, Hori Masaru, Ikehara Yuzuru, Morii Eiichi, Effect of plasma-activated medium on the decrease of tumorigenic population in lymphoma, Pathology - Research and Practice, 213, 7, 2017. Crossref

  10. Trimukhe Ajinkya M., Pandiyaraj K. N., Patekar Mukesh, Miller Vandana, Deshmukh Rajendra R., Perspectives and Advances of Nonthermal Plasma Technology in Cancers, IEEE Transactions on Plasma Science, 50, 8, 2022. Crossref

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