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Plasma Medicine

Published 4 issues per year

ISSN Print: 1947-5764

ISSN Online: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Fast Blood Coagulation of Capillary Vessels by Cold Plasma: A Rat Ear Bleeding Model

Volume 1, Issue 3-4, 2011, pp. 241-247
DOI: 10.1615/PlasmaMed.2012005167
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ABSTRACT

Cold atmospheric pressure plasmas previously have been shown to be effective in vitro in generating active species, radicals, and charges, which may aid in various processes of interest to medicine, including blood coagulation. Floating electrode dielectric barrier discharge microsecond-pulsed, high-voltage plasma was used in an animal model of hairless Sprague-Dawley rats to treat an incision on the ear. The results confirm cold plasma's ability to coagulate blood in a live animal model. A small incision in the rat ear, cutting the thin epidermis and slicing through the capillaries, creates a small and controllable wound from which bleeding is observed. Without plasma treatment, the animal bleeds for approximately 2 minutes, whereas a 10-second treatment is sufficient to coagulate blood. Cold plasma floating electrode dielectric barrier discharge was shown to effectively coagulate bleeding small vessels, which may prove beneficial in surgical intervention treatments of, for example, vocal cord surgery, eye surgery, or brain surgery, for which other means of coagulation may be prohibitive. Future animal trials will include larger animals and different bleeding sites, with the potential to move on to human trials.

CITED BY
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  8. Gökçelli Uğur, Ercan Utku Kürşat, İlhan Enver, Argon Asuman, Çukur Elif, Üreyen Orhan, Prevention of Peritoneal Adhesions by Non-Thermal Dielectric Barrier Discharge Plasma Treatment on Mouse Model: A Proof of Concept Study, Journal of Investigative Surgery, 33, 7, 2020. Crossref

  9. Demkin V. P., Melnichuk S. V., Postnikov A. V., 2d-Model of Glow Discharge Atmospheric Pressure Plasma in Helium Formed after Spark Breakdown: Calculation of the Electrophysical and Thermodynamic Parameters, Russian Physics Journal, 62, 10, 2020. Crossref

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  11. Hosseinzadeh Colagar Abasalt, Hasheminasabgorji Elham, Mohadjerani Maryam, Sohbatzadeh Farshad, Karami Hossein, APPJ Discharge Effects on Human Factor VIII:Ag Level in Healthy and Hemophilia A Patient, Iranian Journal of Science and Technology, Transactions A: Science, 44, 1, 2020. Crossref

  12. Heslin Caitlin, Boehm Daniela, Gilmore Brendan F., Megaw Julianne, Freeman Theresa A., Hickok Noreen J., Cullen P. J., Bourke Paula, Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety, Frontiers in Physics, 8, 2021. Crossref

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