Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Biomedical Engineering
SJR: 0.243 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v37.i1-2.10
pages 1-57

The Role of Tissue Engineering in Articular Cartilage Repair and Regeneration

Lijie Zhang
Department of Biomedical Engineering, University of California, Davis, California, USA
Jerry Hu
Department of Biomedical Engineering, University of California, Davis, California, USA
Kyriacos A. Athanasiou
Department of Bioengineering, Rice University, Houston, Texas, USA


Articular cartilage repair and regeneration continue to be largely intractable because of the poor regenerative properties of this tissue. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased articular cartilage functionality, has evoked intense interest and holds great potential for improving articular cartilage therapy. This review provides an overall description of the current state of and progress in articular cartilage repair and regeneration. Traditional therapies and related problems are introduced. More importantly, a variety of promising cell sources, biocompatible tissue engineered scaffolds, scaffoldless techniques, growth factors, and mechanical stimuli used in current articular cartilage tissue engineering are reviewed. Finally, the technical and regulatory challenges of articular cartilage tissue engineering and possible future directions are also discussed.

Articles with similar content:

Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells: Characterization, Differentiation, and Applications in Cartilage Tissue Engineering
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 4
Xiang Sui, Yu Zhang, Xu Li, Zehao Wang, Shuang Gao, Quanyi Guo, Mingjie Wang, Shi Shen, Mingxue Chen, Xiaoguang Jing, Aiyuan Wang, Xueliang Zhang, Weimin Guo, Bin Zhang, Jiang Peng, Shibi Lu, Hai Xian, Zengzeng Zhang, Yu Wang, Shuyun Liu, Chunxiang Hao
Scaffolds: A Novel Carrier and Potential Wound Healer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 4
Tarun Garg, Chetan Chaudhary
Scaffolds for Articular Cartilage Repair
Journal of Long-Term Effects of Medical Implants, Vol.22, 2012, issue 3
Daniel A. Grande, Adam Graver, Ashley Olson
Dental Tissue−Derived Mesenchymal Stem Cells: Applications in Tissue Engineering
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Jay R. Dave, Geetanjali B. Tomar
Strategies for Regeneration of Heart Muscle
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 1
Glenn R. Gaudette, Ira S. Cohen, Jacques P. Guyette