Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Biomedical Engineering
SJR: 0.243 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v28.i12.100
pages 53-59

Computer Simulation and Geometric Design of Endarterectomized Carotid Artery Bifurcations

Sinjae Hyun
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910
Clement Kleinstreuer
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910
Joseph P. Archie, Jr.
Vascular Surgery, Wake Medical Center, Raleigh, NC 27610

ABSTRACT

The main goal of this computational study is to establish surgical guidelines for optimal geometries of carotid endarterectomy reconstructions that may measurably reduce postoperative complications, that is, thrombosis, stroke, and/or restenosis. The underlying hypotheses are that nonuniform hemodynamics, or "disturbed flows," are linked to arterial diseases and consequently that minimization of "disturbed flow" indicators leads to geometric bifurcation designs that lower postoperative complication rates. Considering transient 3-D laminar blood flow in partially occluded, in-plane, rigid-wall carotid artery bifurcations, the results presented include time-averaged indicators of "disturbed flow", such as the wall shear stress, spatial wall shear stress gradient, and wall shear stress angle deviation. In addition, trajectories and deposition patterns of critical blood particles (i.e., monocytes) are shown and evaluated. Within given physiological constraints, the vessel geometry was then changed in order to reduce the magnitudes of key indicators associated with thrombosis (i.e., blood clot formation) or restenosis (e.g., renewed atherosclerosis and/or hyperplasia). The quantitative results and knowledge base generated will be crucial for future clinical trials.


Articles with similar content:

Hemodynamic Parameters and Early Intimal Thickening in Branching Blood Vessels
Critical Reviews™ in Biomedical Engineering, Vol.45, 2017, issue 1-6
Joseph P. Archie, Jr., Sinjae Hyun, J. R. Buchanan, Jr., P. W. Longest, Clement Kleinstreuer, George A. Truskey
Hemodynamic Parameters and Early Intimal Thickening in Branching Blood Vessels
Critical Reviews™ in Biomedical Engineering, Vol.29, 2001, issue 1
Joseph P. Archie, Jr., Sinjae Hyun, P. W. Longest, Clement Kleinstreuer, J. R. Buchanan, George A. Truskey
Computational Analyses and Design Improvements of Graft-to-Vein Anastomoses
Critical Reviews™ in Biomedical Engineering, Vol.28, 2000, issue 1&2
P. W. Longest, Clement Kleinstreuer, P. J. Andreotti
Shear Stress and Shear-Induced Particle Residence in Stenosed Blood Vessels
International Journal for Multiscale Computational Engineering, Vol.6, 2008, issue 2
Lucy T. Zhang
The Combination of Magnetic Resonance Angiography and Computational Fluid Dynamics: A Critical Review
Critical Reviews™ in Biomedical Engineering, Vol.26, 1998, issue 4
X. Y. Xu, M. W. Collins, M. Bourne, Q. Long, T. M. Griffith