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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Blood Vessel Maturation in Health and Disease and its Implications for Vascularization of Engineered Tissues

Volume 43, Issue 5-6, 2015, pp. 433-454
DOI: 10.1615/CritRevBiomedEng.2016016063
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ABSTRACT

Engineered blood vessels have often been found to be immature and unstable. Similarly, numerous pathologies such as diabetic retinopathy and cancer are characterized by highly abnormal, defective, hypervascular networks, consisting of immature, leaky, and irregular vessels with a marked loss of perivascular cell coverage. An emerging therapeutic concept in treatment of such vascular diseases and their management is the potential to normalize blood vessels by strengthening the cellular components that form the vascular network. Vessel normalization is characterized by the reduction in the number and size of immature vessels, a decrease in interstitial fluid pressure, and increase in perivascular cell coverage. Understanding the molecular and cellular defects associated with abnormal blood vessels will allow us to find appropriate treatment options that can promote normal blood vessel development. These, in turn, can be applied to improve vessel maturation in engineered tissues. In this review, we describe the major perivascular abnormalities associated with various human diseases and engineered vasculatures and the major advances in obtaining mature vasculatures for translational applications.

CITED BY
  1. Altalhi Wafa, Sun Xuetao, Sivak Jeremy M., Husain Mansoor, Nunes Sara S., Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner, Biomaterials, 119, 2017. Crossref

  2. Krishnan Laxminarayanan, LaBelle Steven A., Ruehle Marissa A., Weiss Jeffrey A., Hoying James B., Guldberg Robert E., Mechanical Regulation of Microvascular Growth and Remodeling, in Vascularization for Tissue Engineering and Regenerative Medicine, 2019. Crossref

  3. Altalhi Wafa, Hatkar Rupal, Hoying James B., Aghazadeh Yasaman, Nunes Sara S., Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation, Cellular and Molecular Bioengineering, 12, 5, 2019. Crossref

  4. Tian Wentao, Cao Chenghui, Shu Long, Wu Fang, <p>Anti-Angiogenic Therapy in the Treatment of Non-Small Cell Lung Cancer</p>, OncoTargets and Therapy, Volume 13, 2020. Crossref

  5. Li Meng, Qi Zhongwen, Zhang Junping, Zhu Ke, Wang Yueyao, Effect and Mechanism of Si-Miao-Yong-An on Vasa Vasorum Remodeling in ApoE−/− Mice with Atherosclerosis Vulnerable Plague, Frontiers in Pharmacology, 12, 2021. Crossref

  6. Mourad Omar, Nkennor Blessing, Nunes Sara S., Compounding effects of diabetes in vessel formation in microvessel fragment–based engineered constructs, in The Science, Etiology and Mechanobiology of Diabetes and its Complications, 2021. Crossref

  7. Aghazadeh Yasaman, Poon Frankie, Sarangi Farida, Wong Frances T.M., Khan Safwat T., Sun Xuetao, Hatkar Rupal, Cox Brian J., Nunes Sara S., Nostro M. Cristina, Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models, Cell Stem Cell, 28, 11, 2021. Crossref

  8. Krishnan Laxminarayanan, LaBelle Steven A., Ruehle Marissa A., Weiss Jeffrey A., Hoying James B., Guldberg Robert E., Mechanical Regulation of Microvascular Growth and Remodeling, in Vascularization for Tissue Engineering and Regenerative Medicine, 2021. Crossref

  9. Giatromanolaki Alexandra, Kouroupi Maria, Kontomanolis Emmanuel N., Koukourakis Michael I., Regulatory tumor-infiltrating lymphocytes prevail in endometrial tumors with low vascular survival ability, Immunobiology, 226, 3, 2021. Crossref

  10. Laschke Matthias W., Gu Yuan, Menger Michael D., Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches, Frontiers in Physiology, 13, 2022. Crossref

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