Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2014011578
pages 193-212

Drug-Coated Percutaneous Balloon Catheters

Jayesh V. Betala
Department of Bioengineering, Clemson University, Clemson, South Carolina
Eugene M. Langan III
Department of Vascular Surgery, Greenville Health System, Greenville, South Carolina
jayesh betala
Clemson University


Percutaneous transluminal angioplasty revolutionized coronary and peripheral revascularization. However, it is always accompanied by major drawbacks such as elastic recoil and neointimal hyperplasia. Percutaneous transluminal angioplasty along with bare metal stents reduced elastic recoil, but in-stent restenosis (ISR) and peripheral artery stenting remain problems. Drug-eluting stents addressed the issue of ISR, but late stent thrombosis and delayed endothelialization, along with longer dual antiplatelet therapy, are of concern. Non-stent-based delivery such as drug-coated balloons (DCBs) that can deliver drugs to inhibit ISR or to de novo lesions, are emerging at a rapid pace. DCBs carry an active drug and a nonpolymeric carrier molecule or excipient that enhance the bioavailability of the drug to the vessel wall. Preliminary studies of paclitaxel show sustained delivery is not required to inhibit proliferation of vascular smooth muscle cells, which leds to the development and evolution of DCBs. Recent clinical trials have been successful in mitigating ISR in coronary and peripheral arteries, but not in de novo lesions of coronary arteries. Clinical studies, although limited to date, show a promising future for DCBs.

Articles with similar content:

Magnetic Resonance Imaging in Clinical Cardiac Electrophysiology
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 5
Ravi Ranjan
Phosphorylcholine-Coated Stents
Journal of Long-Term Effects of Medical Implants, Vol.12, 2002, issue 4
Andrew L. Lewis, Peter W. Stratford
A Review on Phosphorylcholine-Coated Stents
Journal of Long-Term Effects of Medical Implants, Vol.27, 2017, issue 2-4
Andrew L. Lewis, Peter W. Stratford
Colloidal Carriers: A Rising Tool for Therapy of Tuberculosis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 4
Suresh P. Vyas, Manish K. Gupta, Swati Gupta, Pankaj Kumar
Role of Isometric Handgrip Training in the Management of Hypertension: Insights from Cardiovascular Stress Reactivity Testing
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.22, 2010, issue 1-4
Mark Badrov, Philip Millar, Cheri L. McGowan