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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Sepsis through the Eyes of an Engineer− Why Treatments Have Succeeded and Failed

Volume 40, Issue 4, 2012, pp. 353-361
DOI: 10.1615/CritRevBiomedEng.v40.i4.90
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ABSTRACT

The sepsis syndrome is an old phenomenon. A destructive response to a system disturbance, it manifests as widespread inflammation. Over the past two centuries, biomedical research has identified triggers and described components of the pathways that underlie the sepsis syndrome. Attempts at translating these findings into preventive and therapeutic interventions have met with varying levels of success. In this chapter, we examine the history of sepsis science through an engineering lens. Patterned attempts to intervene in the natural history of the sepsis syndrome will be discussed in parallel with similar, hypothetical adjustments made to a model system from the engineering canon. This juxtaposition will facilitate our review of the history of sepsis science. Using the logic of systems engineering and network science, we propose a way forward.

CITED BY
  1. Androulakis Ioannis P., A chemical engineer's perspective on health and disease, Computers & Chemical Engineering, 71, 2014. Crossref

  2. Buchman Timothy George, From data patterns to biological mechanism in critical illness: The role of engineering, Journal of Critical Care, 29, 4, 2014. Crossref

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