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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Recent Advances in Cancer Stem Cell Targeted Therapy

Volume 24, Issue 1, 2019, pp. 1-20
DOI: 10.1615/CritRevOncog.2018029574
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ABSTRACT

The cancer stem cells (CSCs) are a subpopulation of cancer cells with unique properties of self-renewal and differentiation potential. Recent evidence suggests that these cells might be responsible for tumor relapse and treatment resistance. Conventional cancer treatment modalities like chemotherapy and radiotherapy usually fail in eradicating CSCs in a tumor mass. Preclinical studies aiming at targeting CSCs have yielded great promise to increase the cancer cure rate. Likewise, targeting of conventional chemotherapeutic drugs to the CSCs and new small molecule inhibitors of stem-cell signaling pathways in humans carry the potential of improving the cancer management. Dendritic cell (DC)–based vaccines seem to be safe and efficient tools in targeting CSCs. The combination of DC vaccines with immune-checkpoint inhibitors is also promising. The viral vectors, particularly the oncolytic viruses, targeting CSCs have emerged as potential curative agents in cancer treatment. Here, we review the recent advances in targeting CSCs via stem cell markers, signaling pathways, immune system, cancer vaccines, and viral treatments.

CITED BY
  1. Mehraj Umar, Ganai Rais A., Macha Muzafar A., Hamid Abid, Zargar Mohammed A., Bhat Ajaz A., Nasser Mohd Wasim, Haris Mohammad, Batra Surinder K., Alshehri Bader, Al-Baradie Raid Saleem, Mir Manzoor A., Wani Nissar Ahmad, The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities, Cellular Oncology, 44, 6, 2021. Crossref

  2. Zhang Qi, Li Wei, Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy, World Journal of Stem Cells, 14, 4, 2022. Crossref

  3. Zhao Huijie, Liu Huiyang, Yang Yihan, Wang Honggang, The Protective Role of 4-Acetylarylquinolinol B in Different Pathological Processes, Current Issues in Molecular Biology, 44, 5, 2022. Crossref

  4. Geng Shengkai, Fu Yipeng, Fu Shaomei, Wu Kejin, A tumor microenvironment-related risk model for predicting the prognosis and tumor immunity of breast cancer patients, Frontiers in Immunology, 13, 2022. Crossref

  5. Assidi Mourad, Strong prognostic value of SLAMF7 protein expression in patients with lymph node‑positive breast cancer, Oncology Letters, 24, 6, 2022. Crossref

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