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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Cancer Stem Cells, Their Microenvironment and Anoikis

Volume 24, Issue 1, 2019, pp. 27-34
DOI: 10.1615/CritRevOncog.2018029433
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ABSTRACT

Tumors are composed of a variety of cancer cells, all of which contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) have an important role in the initiation and progression of cancer. CSCs are maintained extrinsically within the tumor microenvironment, which contains both cellular and physical factors. As a barrier to metastases, cells normally undergo apoptosis (cell death process) after they lose contact with their extracellular matrix or neighboring cells. This cell death process has been termed "anoikis". The tumor cells that acquire malignant potential develop mechanisms to resist anoikis. The tumor microenvironment has been acknowledged to contribute to anoikis resistance of bystander cancer cells via modulation of the matrix stiffness, enhancement of oxidative stress, production of pro-survival soluble factors, trigger of epithelial–mesenchymal transition (EMT), and self-renewal ability, thus leading to metabolic deregulations of cancer cells. In this article, we review the significance of perivascular cells, extracellular matrix, tumor stiffness, and hypoxia in the regulation of CSC plasticity and anoikis resistance. With a better understanding of the CSC interaction with its niche and anoikis resistance, it is possible to identify potential therapeutic targets for the development of more effective treatments against cancer.

CITED BY
  1. Khurana Sanchita, Bhattacharyya Shalmoli, Interaction of cancer cells with mesenchymal stem cells: implications in metastatic progression, Journal of the Indian Institute of Science, 100, 3, 2020. Crossref

  2. Moradpoor Raheleh, Gharebaghian Ahmad, Shahi Farhad, Mousavi Asadollah, Salari Sina, Akbari Mohammad Esmaeil, Ajdari Soheila, Salimi Mona, Identification and Validation of Stage-Associated PBMC Biomarkers in Breast Cancer Using MS-Based Proteomics, Frontiers in Oncology, 10, 2020. Crossref

  3. Liu Jingjing, Cao Liming, Meng Jie, Li Yuanyuan, Deng Pengbo, Pan Pinhua, Hu Chengping, Yang Huaping, RETRACTED ARTICLE: The fibrotic microenvironment promotes the metastatic seeding of tumor cells into the lungs via mediating the ZEB1-AS1/miR-200b-3p/ZEB1 signaling, Cell Cycle, 19, 20, 2020. Crossref

  4. Jang Jinah, Hagenbuchner Judith, Nothdurfter Daniel, Ausserlechner Michael J., 3D bioprinting: novel approaches for engineering complex human tissue equivalents and drug testing, Essays in Biochemistry, 65, 3, 2021. Crossref

  5. Ekmekci Sumeyye, Aktas Safiye, The Concept and Mechanisms of Metastasis, in Biomarkers in Carcinoma of Unknown Primary, 2022. Crossref

  6. Zandalinas Sara I., Fritschi Felix B., Mittler Ron, Global Warming, Climate Change, and Environmental Pollution: Recipe for a Multifactorial Stress Combination Disaster, Trends in Plant Science, 26, 6, 2021. Crossref

  7. Olszewska Aleksandra, Borkowska Agata, Granica Monika, Karolczak Justyna, Zglinicki Bartosz, Kieda Claudine, Was Halina, Escape From Cisplatin-Induced Senescence of Hypoxic Lung Cancer Cells Can Be Overcome by Hydroxychloroquine, Frontiers in Oncology, 11, 2022. Crossref

  8. Chen Xiaopeng, Zhang Xiaowei, Jiang Yitong, Zhang Xuemei, Liu Min, Wang Shanna, Liu Shaoqiong, Liang Haiyan, Liu Chunhua, YAP1 activation promotes epithelial–mesenchymal transition and cell survival of renal cell carcinoma cells under shear stress, Carcinogenesis, 43, 4, 2022. Crossref

  9. Khan Sameer Ullah, Fatima Kaneez, Malik Fayaz, Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis, Clinical & Experimental Metastasis, 39, 5, 2022. Crossref

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