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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Multilayered Regulation of the Oncogenic Protein YY1

Volume 22, Issue 1-2, 2017, pp. 109-129
DOI: 10.1615/CritRevOncog.2017020959
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ABSTRACT

The multifunctional protein Yin Yang 1 (YY1) plays critical roles in tumorigenesis. YY1 has been shown to be involved in the development, progression, resistance, and invasiveness of many types of cancers. Today, the value of YY1 as a prognostic marker and as a potential target in cancer therapy is being explored by multiple research groups around the world. Over the past 25 years, we have accumulated a wealth of information about the wide-ranging biological functions of YY1 at the molecular, cellular, and organismal levels. However, our knowledge of how YY1 is regulated and what regulates it has lagged behind. In the past few years, there has been a significant increase in the research addressing this issue. In this review, we summarize and analyze recent findings about the regulation of YY1 at multiple levels. We emphasize the necessity for deeper insights into these regulatory mechanisms if YY1 is to find its way to the clinical setting.

CITED BY
  1. Michele Gabriele, Giuseppe Testa, Anders Hansen, Molecular mechanisms of YY1 overexpression in human cancers and its prognostic significance, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  2. Wang Yuhao, Bonavida Benjamin, The role of YY1 in the pathogenesis of rheumatoid arthritis: A tale of cytokines, ncRNAs, and aberrant fibroblast-like synoviocytes (FLSs), in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  3. Santiago Fernando S, Li Yue, Zhong Ling, Raftery Mark J, Lins Laurence, Khachigian Levon M, Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury, Cardiovascular Research, 117, 11, 2021. Crossref

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