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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Extracellular Vesicle-Mediated Reversal of Paclitaxel Resistance in Prostate Cancer

Volume 20, Issue 5-6, 2015, pp. 407-417
DOI: 10.1615/CritRevOncog.v20.i5-6.120
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ABSTRACT

Prostate cancer (PCa) is the most common solid tumor in males and the second leading cause of cancer-related deaths in males in the United States. The current first line therapy for metastatic PCa is androgen deprivation therapy and is initially effective against the disease. However, castrate resistant prostate cancer (CRPC) develops in many men within 18−36 months, rendering this treatment ineffective. Chemotherapy, with a class of drugs known as taxanes is the standard-of-care cytotoxic option in metastatic castrate resistant PCa (mCRPC). However, the overall survival advantage for chemotherapy in mCRPC is only 2.2 months and the cancer cells often become resistant to these drugs as well. Once patients fail chemotherapy the progression to death is inevitable. Extracellular vesicles (EVs) are involved in cell signaling and play a role in cancer progression. Previous work has demonstrated that EVs are involved in the development of drug resistance in cancer cells. We report the reversal of taxane resistance and tumorigenic phenotype in PCa cells after EVs treatment. This study suggests that EVs represent a potentially novel therapeutic treatment option for CRPC.

CITED BY
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  5. Borgovan Theo, Crawford Lorin, Nwizu Chibuikem, Quesenberry Peter, Stem Cells and Extracellular Vesicles: Biological Regulators of Physiology and Disease, in Innovations in Cell Research and Therapy, 2020. Crossref

  6. Saber Saber H., Ali Hamdy E. A., Gaballa Rofaida, Gaballah Mohamed, Ali Hamed I., Zerfaoui Mourad, Abd Elmageed Zakaria Y., Exosomes are the Driving Force in Preparing the Soil for the Metastatic Seeds: Lessons from the Prostate Cancer, Cells, 9, 3, 2020. Crossref

  7. Fonsato Valentina, De Lena Michela, Tritta Stefania, Brossa Alessia, Calvetti Ruggero, Tetta Ciro, Camussi Giovanni, Bussolati Benedetta, Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation, Oncotarget, 9, 90, 2018. Crossref

  8. De Martino Viviana, Rossi Michela, Battafarano Giulia, Pepe Jessica, Minisola Salvatore, Del Fattore Andrea, Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?, International Journal of Molecular Sciences, 22, 22, 2021. Crossref

  9. Zhang Ying, Kim Jin-Soo, Wang Tian-Zhen, Newton Robert U., Galvão Daniel A., Gardiner Robert A., Hill Michelle M., Taaffe Dennis R., Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression, Frontiers in Oncology, 11, 2021. Crossref

  10. Saldana Carolina, Majidipur Amene, Beaumont Emma, Huet Eric, de la Taille Alexandre, Vacherot Francis, Firlej Virginie, Destouches Damien, Extracellular Vesicles in Advanced Prostate Cancer: Tools to Predict and Thwart Therapeutic Resistance, Cancers, 13, 15, 2021. Crossref

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  12. Mosca Luciana, Ilari Andrea, Fazi Francesco, Assaraf Yehuda G., Colotti Gianni, Taxanes in cancer treatment: Activity, chemoresistance and its overcoming, Drug Resistance Updates, 54, 2021. Crossref

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