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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Homeobox Gene Involvement in Normal Hematopoiesis and in the Pathogenesis of Childhood Leukemias

Volume 22, Issue 3-4, 2017, pp. 157-185
DOI: 10.1615/CritRevOncog.2017024465
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ABSTRACT

Homeobox (HOX) genes are a superfamily of highly conserved genes with essential functions in many aspects of mammalian development. Their expression is tightly regulated throughout the duration of definitive hematopoiesis, so the pathogenetic mechanism that leads to leukemia suggests that malignant transformation is directly intertwined with the deregulation of HOX gene expression. Even though HOX gene involvement has been reviewed extensively in adult leukemias, childhood leukemias have received much less attention and mainly in the context of leukemias harboring MLL (mixed-lineage leukemia) gene translocations. In recent years, scientific evidence has highlighted HOX gene involvement in the development of other subtypes of childhood leukemias and added HOX gene family members that were previously unrelated to the pathogenesis of childhood leukemia. This has significant implications when considering both the risk stratification of pediatric patients and potential targets for successful therapy. Through the identification of HOX target genes, their resulting interactions, and the cognate signaling pathways, we hope to gain a better understanding of the molecular mechanism(s) underlying the ectopic activation of these genes in childhood leukemias and subsequently to reveal new molecular targets for successful therapy in cases of poor prognosis or resistant disease.

CITED BY
  1. Jonkers Joy, Pai Priya, Sukumar Saraswati, Multiple roles of HOX proteins in Metastasis: Let me count the ways, Cancer and Metastasis Reviews, 39, 3, 2020. Crossref

  2. Li Juanjuan, Downs Bradley M., Cope Leslie M., Fackler Mary Jo, Zhang Xiuyun, Song Chuan-gui, VandenBussche Christopher, Zhang Kejing, Han Yong, Liu Yufei, Tulac Suzana, Venkatesan Neesha, de Guzman Timothy, Chen Chuang, Lai Edwin W., Yuan Jingping, Sukumar Saraswati, Automated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer, npj Breast Cancer, 7, 1, 2021. Crossref

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