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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Metabolic Syndrome, Aging, and Cancer

Volume 18, Issue 6, 2013, pp. 515-529
DOI: 10.1615/CritRevOncog.2014010612
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ABSTRACT

Older patients present with an average of three comorbidities beside their cancer. One of the most frequent age-associated comorbidities is the metabolic syndrome. In the USA, its prevalence is greater than 40% in subjects above the age of 60. The metabolic syndrome is associated with an increased risk of cancer across multiple tumor types. It also worsens the prognosis of those cancers, increasing both their relapse and death rates. In this review, we assess the possible mediating mechanisms of this association. The evidence points toward a key role of hyperinsulinemia itself, and notably its impact on metabolic/proliferation pathways involving mTOR. We will review current therapeutic trials that are specifically targeting these pathways, and draw some parallels with the use of some of these same agents in animal aging studies.

CITED BY
  1. Tower John, Mitochondrial maintenance failure in aging and role of sexual dimorphism, Archives of Biochemistry and Biophysics, 576, 2015. Crossref

  2. Wen Y.-S., Huang C., Zhang X., Qin R., Lin P., Rong T., Zhang L.-J., Impact of metabolic syndrome on the survival of Chinese patients with resectable esophageal squamous cell carcinoma, Diseases of the Esophagus, 29, 6, 2016. Crossref

  3. Blagosklonny Mikhail V., Paradoxes of senolytics, Aging, 10, 12, 2018. Crossref

  4. Young Andrew R.J., Cassidy Liam D., Narita Masashi, Autophagy and senescence, converging roles in pathophysiology as seen through mouse models, in Autophagy and Senescence in Cancer Therapy, 150, 2021. Crossref

  5. Liu Zenan, Bi Hai, He Wei, Zhu Xuehua, He Jide, Lu Min, Lu Jian, Preoperative Metabolic Syndrome and HDL-C Level Predict the Prognosis of Patients Following Radical Cystectomy: A Propensity Score Matching Study, Frontiers in Oncology, 12, 2022. Crossref

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