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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Progress in Lipid-Based Nanoparticles for Cancer Therapy

Volume 19, Issue 3-4, 2014, pp. 247-260
DOI: 10.1615/CritRevOncog.2014011815
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ABSTRACT

Most conventional cancer therapeutics gain limited access to many types of tumors while having considerable adverse effects, resulting in low therapeutic efficacy and high toxicity. Therefore, research has now focused on the development of novel drug delivery systems (DDS) with the goal of maintaining high therapeutic drug levels at malignant cells and as low as possible drug levels in other cells. The introduction of nanotechnology has addressed some of these problems and opened up new avenues for improved cancer therapy. The design of nanoparticles for DDS takes into consideration issues such as targeting, controlled drug release and enhanced penetration via biological barriers. In this review we describe the design principles of targeted DDS for cancer therapy and the types of nanoparticles that are under development. Emphasis is put on lipid-based nanoparticles, particularly bolaamphiphilic vesicles that have tremendous potential in delivering therapeutic and diagnostic agents to specific cells following systemic administration.

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  2. Dao Bich Ngoc, Viard Mathias, Martins Angelica N., Kasprzak Wojciech K., Shapiro Bruce A., Afonin Kirill A., Triggering RNAi with multifunctional RNA nanoparticles and their delivery, DNA and RNA Nanotechnology, 2, 1, 2015. Crossref

  3. Ewonkem Monique B., Grinberg Sarina, Lemcoff Gabriel, Shaubi Eleonora, Linder Charles, Heldman Eliahu, Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery, Tetrahedron, 71, 45, 2015. Crossref

  4. Sacchetti Francesca, Marraccini Chiara, D’Arca Domenico, Pelà Michela, Pinetti Diego, Maretti Eleonora, Hanuskova Miriam, Iannuccelli Valentina, Costi Maria Paola, Leo Eliana, Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery, Colloids and Surfaces B: Biointerfaces, 136, 2015. Crossref

  5. Fernandes Renata S., Mota Luciene G., Kalbasi Anusha, Moghbel Mateen, Werner Thomas J., Alavi Abass, Rubello Domenico, Cardoso Valbert N., de Barros Andre Luis B., 99mTc-phytate as a diagnostic probe for assessing inflammatory reaction in malignant tumors, Nuclear Medicine Communications, 36, 10, 2015. Crossref

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