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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Ikaros and Tumor Suppression in Acute Lymphoblastic Leukemia

Volume 16, Issue 1-2, 2011, pp. 3-12
DOI: 10.1615/CritRevOncog.v16.i1-2.20
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ABSTRACT

The Ikzf1 gene encodes Ikaros−a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function.

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  1. Rivina Leena, Schiestl Robert, , 84, 2013. Crossref

  2. Linabery Amy M., Blommer Crystal N., Spector Logan G., Davies Stella M., Robison Leslie L., Ross Julie A., ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group, Leukemia Research, 37, 8, 2013. Crossref

  3. Gorzkiewicz Anna, Walczewska Anna, Functions of the Ikaros transcription factor and the role of IKZF1 gene defects in hematological malignancies, Acta Haematologica Polonica, 46, 1, 2015. Crossref

  4. Rivina Leena, Schiestl Robert, Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review, International Journal of Environmental Research and Public Health, 10, 1, 2012. Crossref

  5. Beer Philip A., Knapp David J.H.F., Kannan Nagarajan, Miller Paul H., Babovic Sonja, Bulaeva Elizabeth, Aghaeepour Nima, Rabu Gabrielle, Rostamirad Shabnam, Shih Kingsley, Wei Lisa, Eaves Connie J., A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic Cells, Stem Cell Reports, 3, 5, 2014. Crossref

  6. Rolland Thomas, Taşan Murat, Charloteaux Benoit, Pevzner Samuel J., Zhong Quan, Sahni Nidhi, Yi Song, Lemmens Irma, Fontanillo Celia, Mosca Roberto, Kamburov Atanas, Ghiassian Susan D., Yang Xinping, Ghamsari Lila, Balcha Dawit, Begg Bridget E., Braun Pascal, Brehme Marc, Broly Martin P., Carvunis Anne-Ruxandra, Convery-Zupan Dan, Corominas Roser, Coulombe-Huntington Jasmin, Dann Elizabeth, Dreze Matija, Dricot Amélie, Fan Changyu, Franzosa Eric, Gebreab Fana, Gutierrez Bryan J., Hardy Madeleine F., Jin Mike, Kang Shuli, Kiros Ruth, Lin Guan Ning, Luck Katja, MacWilliams Andrew, Menche Jörg, Murray Ryan R., Palagi Alexandre, Poulin Matthew M., Rambout Xavier, Rasla John, Reichert Patrick, Romero Viviana, Ruyssinck Elien, Sahalie Julie M., Scholz Annemarie, Shah Akash A., Sharma Amitabh, Shen Yun, Spirohn Kerstin, Tam Stanley, Tejeda Alexander O., Trigg Shelly A., Twizere Jean-Claude, Vega Kerwin, Walsh Jennifer, Cusick Michael E., Xia Yu, Barabási Albert-László, Iakoucheva Lilia M., Aloy Patrick, De Las Rivas Javier, Tavernier Jan, Calderwood Michael A., Hill David E., Hao Tong, Roth Frederick P., Vidal Marc, A Proteome-Scale Map of the Human Interactome Network, Cell, 159, 5, 2014. Crossref

  7. Kunz Manfred, König Inke R., Schillert Arne, Kruppa Jochen, Ziegler Andreas, Grallert Harald, Müller-Nurasyid Martina, Lieb Wolfgang, Franke Andre, Ranki Annamari, Panelius Jaana, Koskenmies Sari, Hasan Taina, Kere Juha, Rönn Ann-Charlotte, Simon Jan C., Schmidt Enno, Wenzel Joerg, Tüting Thomas, Landsberg Jennifer, Zeller Tanja, Blankenberg Stefan, Gläser Regine, Patsinakidis Nikolaos, Kuhn Annegret, Ibrahim Saleh M., Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus, Experimental Dermatology, 24, 7, 2015. Crossref

  8. Beer Philip A., Knapp David J. H. F., Miller Paul H., Kannan Nagarajan, Sloma Ivan, Heel Kathy, Babovic Sonja, Bulaeva Elizabeth, Rabu Gabrielle, Terry Jefferson, Druker Brian J., Loriaux Marc M., Loeb Keith R., Radich Jerald P., Erber Wendy N., Eaves Connie J., Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression, Blood, 125, 3, 2015. Crossref

  9. Bottardi Stefania, Mavoungou Lionel, Milot Eric, IKAROS: a multifunctional regulator of the polymerase II transcription cycle, Trends in Genetics, 31, 9, 2015. Crossref

  10. Brown Karen E., The Continuing Flight of Ikaros, in The Functional Nucleus, 2016. Crossref

  11. Capece Daria, Zazzeroni Francesca, Mancarelli Maria Michela, Verzella Daniela, Fischietti Mariafausta, Di Tommaso Ambra, Maccarone Rita, Plebani Sara, Di Ianni Mauro, Gulino Alberto, Alesse Edoardo, Akagi Tadayuki, A Novel, Non-canonical Splice Variant of the Ikaros Gene Is Aberrantly Expressed in B-cell Lymphoproliferative Disorders, PLoS ONE, 8, 7, 2013. Crossref

  12. Gowda Chandrika, Song Chunhua, Kapadia Malika, Payne Jonathon L., Hu Tommy, Ding Yali, Dovat Sinisa, Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros, Advances in Biological Regulation, 63, 2017. Crossref

  13. Gowda Chandrika, Soliman Mario, Kapadia Malika, Ding Yali, Payne Kimberly, Dovat Sinisa, Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia, Advances in Biological Regulation, 65, 2017. Crossref

  14. Yu Wei, Zhang Kun, Wang Zhongyi, Zhang Jiayu, Chen Tong, Jin Lifang, Functional variant in the promoter region of IL-27 alters gene transcription and confers a risk for ulcerative colitis in northern Chinese Han, Human Immunology, 78, 3, 2017. Crossref

  15. Wu Meng-Yun, Dai Dao-Qing, Zhang Xiao-Fei, Zhu Yuan, Wei Zhi, Cancer Subtype Discovery and Biomarker Identification via a New Robust Network Clustering Algorithm, PLoS ONE, 8, 6, 2013. Crossref

  16. Nelson Nadine, Xiang Shengyan, Zhang Xiaohong, Gilvary Danielle, Djeu Julie, Husain Kazim, Malafa Mokenge, Vohra Nasreen, Pilon-Thomas Shari, Ghansah Tomar, Heeschen Christopher, Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis, PLOS ONE, 10, 1, 2015. Crossref

  17. Patel Rutulkumar, Zhang Luchang, Desai Amar, Hoenerhoff Mark J., Kennedy Lucy H., Radivoyevitch Tomas, Ban Yuguang, Chen Xi Steven, Gerson Stanton L., Welford Scott M., Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure, Leukemia, 33, 5, 2019. Crossref

  18. Dimopoulos Konstantinos, Fibiger Munch-Petersen Helga, Winther Eskelund Christian, Dissing Sjö Lene, Ralfkiaer Elisabeth, Gimsing Peter, Grønbaek Kirsten, Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma, Leukemia & Lymphoma, 60, 1, 2019. Crossref

  19. Gowda Chandrika, Song Chunhua, Ding Yali, Iyer Soumya, Dhanyamraju Pavan K, McGrath Mary, Bamme Yevgeniya, Soliman Mario, Kane Shriya, Payne Jonathon L., Dovat Sinisa, Cellular signaling and epigenetic regulation of gene expression in leukemia, Advances in Biological Regulation, 75, 2020. Crossref

  20. Costa Odile, Schneider Pascale, Coquet Laurent, Chan Philippe, Penther Dominique, Legrand Elisabeth, Jouenne Thierry, Vasse Marc, Vannier Jean-Pierre, Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21), Clinical Proteomics, 11, 1, 2014. Crossref

  21. Gowda Chandrika, Dovat Sinisa, Genetic Targets in Pediatric Acute Lymphoblastic Leukemia, in Impact of Genetic Targets on Cancer Therapy, 779, 2013. Crossref

  22. Alvarado Ibarra Martha, Antonio De La Peña Celaya Jose, Overview and Current News in Acute Lymphoblastic Leukemia, in Geriatric Medicine and Gerontology, 2019. Crossref

  23. Payne Jonathon L, Song Chunhua, Ding Yali, Dhanyamraju Pavan Kumar, Bamme Yevgeniya, Schramm Joseph W, Desai Dhimant, Sharma Arati, Gowda Chandrika, Dovat Sinisa, Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia, International Journal of Molecular Sciences, 21, 5, 2020. Crossref

  24. Lin Xiaojing, Zou Xingli, Wang Ziming, Fang Qin, Chen Shuya, Huang Jun, Zhe Nana, Yu Meisheng, Zhang Yaming, Wang Jishi, Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL, Oncotarget, 7, 33, 2016. Crossref

  25. Sánchez-Luis Elena, Joaquín-García Andrea, Campos-Laborie Francisco J., Sánchez-Guijo Fermín, De las Rivas Javier, Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells, Biomolecules, 10, 4, 2020. Crossref

  26. Haque Shabirul, Vaiselbuh Sarah R., Silencing of Exosomal miR-181a Reverses Pediatric Acute Lymphocytic Leukemia Cell Proliferation, Pharmaceuticals, 13, 9, 2020. Crossref

  27. Haque Shabirul, Vaiselbuh Sarah R., Vincristine and prednisone regulates cellular and exosomal miR-181a expression differently within the first time diagnosed and the relapsed leukemia B cells, Leukemia Research Reports, 14, 2020. Crossref

  28. Liang Siqi, Yu Haiyuan, Wren Jonathan, Revealing new therapeutic opportunities through drug target prediction: a class imbalance-tolerant machine learning approach, Bioinformatics, 36, 16, 2020. Crossref

  29. Moreno Lorenzana Dafné, Juárez Velázquez María del Rocío, Reyes León Adriana, Martínez Anaya Daniel, Hernández Monterde Adrián, Salas Labadía Consuelo, Navarrete Meneses María del Pilar, Zapata Tarrés Marta, Juárez Villegas Luis, Jarquín Ramírez Berenice, Cárdenas Cardós Rocío, Herrera Almanza Martha, Paredes Aguilera Rogelio, Pérez Vera Patricia, CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways , The Journal of Pathology: Clinical Research, 7, 4, 2021. Crossref

  30. Kuehn Hye Sun, Nunes-Santos Cristiane J, Rosenzweig Sergio D., Germline IKZF1 mutations and their impact on immunity: IKAROS-associated diseases and pathophysiology, Expert Review of Clinical Immunology, 17, 4, 2021. Crossref

  31. Haque Shabirul, Vaiselbuh Sarah R., Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression, Cancer Genetics, 260-261, 2022. Crossref

  32. Budach Stefan, Heinig Matthias, Marsico Annalisa, Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci, Genetics, 203, 4, 2016. Crossref

  33. von Palffy Sofia, Bulaeva Elizabeth, Babovic Sonja, Kannan Nagarajan, Knapp David J.H.F., Wei Lisa, Eaves Connie J., Beer Philip A., Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1+ mouse BA/F3 cells, Experimental Hematology, 43, 7, 2015. Crossref

  34. Xu Xiang-Hong, Huang Xue-Wen, Qun Li, Li Ya-Nan, Wang Yi, Liu Chao, Ma Yanyun, Liu Qing-Mei, Sun Kang, Qian Feng, Jin Li, Wang Jiucun, Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans, Scientific Reports, 4, 1, 2014. Crossref

  35. Iempridee Tawin, Reusch Jessica A., Riching Andrew, Johannsen Eric C., Dovat Sinisa, Kenney Shannon C., Mertz Janet E., Hutt-Fletcher L., Epstein-Barr Virus Utilizes Ikaros in Regulating Its Latent-Lytic Switch in B Cells, Journal of Virology, 88, 9, 2014. Crossref

  36. Liu Mingyuan, Hou Xiaojun, Zhang Ping, Hao Yong, Yang Yiting, Wu Xiongfeng, Zhu Desheng, Guan Yangtai, Microarray gene expression profiling analysis combined with bioinformatics in multiple sclerosis, Molecular Biology Reports, 40, 5, 2013. Crossref

  37. Tokunaga Kenji, Yamaguchi Shunichiro, Iwanaga Eisaku, Nanri Tomoko, Shimomura Taizo, Suzushima Hitoshi, Mitsuya Hiroaki, Asou Norio, High frequency of IKZF1 genetic alterations in adult patients with B ‐cell acute lymphoblastic leukemia , European Journal of Haematology, 91, 3, 2013. Crossref

  38. Wang Wei, He Shipeng, Dong Guoqiang, Sheng Chunquan, Nucleic-Acid-Based Targeted Degradation in Drug Discovery, Journal of Medicinal Chemistry, 65, 15, 2022. Crossref

  39. Yu Wen-Liang, Hua Zi-Chun, Identification of immune and stromal cell infiltration-related gene signature for prognosis prediction in acute lymphoblastic leukemia, Aging, 14, 18, 2022. Crossref

  40. Yang Lin-Kai, Lin Can-Xiang, Li Sheng-Hong, Liang Jia-Ji, Xiao Li-Ling, Xie Guang-Hui, Liu Hong-Wei, Liao Xuan, Novel IKZF3 transcriptomic signature correlates with positive outcomes of skin cutaneous melanoma: A pan-cancer analysis, Frontiers in Genetics, 13, 2022. Crossref

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