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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v23.i6.20
pages 497-523

Lipoproteins: From Physiological Roles to Drug Delivery Potentials

Mehrdad Hamidi
Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Science
Mahshid Foroozesh
Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. BOX 71345-1583, Shiraz, Iran
Abdolhossein Zarrin
Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. BOX 71345-1583, Shiraz, Iran

ABSTRACT

Lipoproteins, the endogenous lipid-protein associations responsible for lipid metabolism within the human body, have attracted interest in recent years for their potential as drug delivery carriers owing to, mainly, their lipophilic/amphiphilic nature, which makes them ideal for interacting with highly lipophilic drugs. After lipoprotein particles have been isolated from the blood, drugs can be "loaded" onto them with a variety of methods. Loading can be done either in soluble/suspended form in a liquid medium or as a dry film. Each method has advantages and disadvantages. The drug-loaded lipoproteins can be modified by the attachment of different ligands that target the particles to specific tissue/cell types within the body. A wide variety of drug molecules both from small molecular or macromolecular structures have been tested successfully, mostly in vitro, for their potential for delivery by lipoprotein carriers.


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