Published 6 issues per year
ISSN Print: 0743-4863
ISSN Online: 2162-660X
Indexed in
New Approaches to Antigen Delivery
ABSTRACT
An improved understanding of immunologic events associated with immunization, die identification of promising new antigens, and an increased capacity to generate these antigens through chemical and biotechnology methods have led to many new vaccine opportunities. Inappropriate antigen exposure, however, can result in unwanted outcomes, such as incomplete protection, allergic reactions, autoimmumty, infection, or even tolerization. Thus, proper antigen delivery is critical for achieving the desired outcome. A number of vaccination approaches have now been described with varied degrees of success. The relative success of these approaches can be correlated with antigen delivery to specific presentation cells and stimulation of the immune system at sites where protective immunity is most appropriate. In addition, a greater understanding of mechanisms involving cells and effector molecules in die events of immunity may allow for improved possibilities for initiating, augmenting, and maintaining the response to a delivered antigen. This review provides insights into die various strategies currently being explored to optimize antigen delivery and the immune response to that antigen.
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McGeary Ross P., Olive Colleen, Toth Istvan, Lipid and carbohydrate based adjuvant/carriers in immunology, Journal of Peptide Science, 9, 7, 2003. Crossref
-
Illum Lisbeth, Nasal drug delivery—possibilities, problems and solutions, Journal of Controlled Release, 87, 1-3, 2003. Crossref
-
Kim Tae-Hee, Jiang Hu-Lin, Jere Dhananjay, Park In-Kyu, Cho Myung-Haing, Nah Jae-Woon, Choi Yun-Jaie, Akaike Toshihiro, Cho Chong-Su, Chemical modification of chitosan as a gene carrier in vitro and in vivo, Progress in Polymer Science, 32, 7, 2007. Crossref
-
Siccardi Dario, Turner Jerrold R., Mrsny Randall J., Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease, Advanced Drug Delivery Reviews, 57, 2, 2005. Crossref
-
Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher A.N, Davis S.S, Chitosan as a novel nasal delivery system for vaccines, Advanced Drug Delivery Reviews, 51, 1-3, 2001. Crossref
-
Buttini Francesca, Colombo Paolo, Rossi Alessandra, Sonvico Fabio, Colombo Gaia, Particles and powders: Tools of innovation for non-invasive drug administration, Journal of Controlled Release, 161, 2, 2012. Crossref
-
Iqbal M, Lin W, Jabbal-Gill I, Davis S.S, Steward M.W, Illum L, Nasal delivery of chitosan–DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice, Vaccine, 21, 13-14, 2003. Crossref
-
Mrsny Randall J., Daugherty Ann L., McKee Marian L., FitzGerald David J., Bacterial toxins as tools for mucosal vaccination, Drug Discovery Today, 7, 4, 2002. Crossref
-
Gaspar Diana, Peres Carina, Florindo Helena, Almeida António, Mucosal Immunization Using Polyester-Based Particulate Systems, in Handbook of Polyester Drug Delivery Systems, 2016. Crossref
-
Alsarra Ibrahim A., Hamed Amel Y., Alanazi Fars K., El Maghraby Gamal M., Vesicular Systems for Intranasal Drug Delivery, in Drug Delivery to the Central Nervous System, 45, 2010. Crossref
-
Kunisawa Jun, Nakagawa Shinsaku, Mayumi Tadanori, Pharmacotherapy by intracellular delivery of drugs using fusogenic liposomes: application to vaccine development, Advanced Drug Delivery Reviews, 52, 3, 2001. Crossref
-
Kunisawa Jun, Nakanishi Tsuyoshi, Takahashi Ichiro, Okudaira Akiko, Tsutsumi Yasuo, Katayama Kazufumi, Nakagawa Shinsaku, Kiyono Hiroshi, Mayumi Tadanori, Sendai Virus Fusion Protein-Mediates Simultaneous Induction of MHC Class I/II-Dependent Mucosal and Systemic Immune Responses Via the Nasopharyngeal-Associated Lymphoreticular Tissue Immune System, The Journal of Immunology, 167, 3, 2001. Crossref