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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

New Approaches to Antigen Delivery

Volume 17, Issue 3, 2000, 84 pages
DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i3.10
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ABSTRACT

An improved understanding of immunologic events associated with immunization, die identification of promising new antigens, and an increased capacity to generate these antigens through chemical and biotechnology methods have led to many new vaccine opportunities. Inappropriate antigen exposure, however, can result in unwanted outcomes, such as incomplete protection, allergic reactions, autoimmumty, infection, or even tolerization. Thus, proper antigen delivery is critical for achieving the desired outcome. A number of vaccination approaches have now been described with varied degrees of success. The relative success of these approaches can be correlated with antigen delivery to specific presentation cells and stimulation of the immune system at sites where protective immunity is most appropriate. In addition, a greater understanding of mechanisms involving cells and effector molecules in die events of immunity may allow for improved possibilities for initiating, augmenting, and maintaining the response to a delivered antigen. This review provides insights into die various strategies currently being explored to optimize antigen delivery and the immune response to that antigen.

CITED BY
  1. McGeary Ross P., Olive Colleen, Toth Istvan, Lipid and carbohydrate based adjuvant/carriers in immunology, Journal of Peptide Science, 9, 7, 2003. Crossref

  2. Illum Lisbeth, Nasal drug delivery—possibilities, problems and solutions, Journal of Controlled Release, 87, 1-3, 2003. Crossref

  3. Kim Tae-Hee, Jiang Hu-Lin, Jere Dhananjay, Park In-Kyu, Cho Myung-Haing, Nah Jae-Woon, Choi Yun-Jaie, Akaike Toshihiro, Cho Chong-Su, Chemical modification of chitosan as a gene carrier in vitro and in vivo, Progress in Polymer Science, 32, 7, 2007. Crossref

  4. Siccardi Dario, Turner Jerrold R., Mrsny Randall J., Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease, Advanced Drug Delivery Reviews, 57, 2, 2005. Crossref

  5. Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher A.N, Davis S.S, Chitosan as a novel nasal delivery system for vaccines, Advanced Drug Delivery Reviews, 51, 1-3, 2001. Crossref

  6. Buttini Francesca, Colombo Paolo, Rossi Alessandra, Sonvico Fabio, Colombo Gaia, Particles and powders: Tools of innovation for non-invasive drug administration, Journal of Controlled Release, 161, 2, 2012. Crossref

  7. Iqbal M, Lin W, Jabbal-Gill I, Davis S.S, Steward M.W, Illum L, Nasal delivery of chitosan–DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice, Vaccine, 21, 13-14, 2003. Crossref

  8. Mrsny Randall J., Daugherty Ann L., McKee Marian L., FitzGerald David J., Bacterial toxins as tools for mucosal vaccination, Drug Discovery Today, 7, 4, 2002. Crossref

  9. Gaspar Diana, Peres Carina, Florindo Helena, Almeida António, Mucosal Immunization Using Polyester-Based Particulate Systems, in Handbook of Polyester Drug Delivery Systems, 2016. Crossref

  10. Alsarra Ibrahim A., Hamed Amel Y., Alanazi Fars K., El Maghraby Gamal M., Vesicular Systems for Intranasal Drug Delivery, in Drug Delivery to the Central Nervous System, 45, 2010. Crossref

  11. Kunisawa Jun, Nakagawa Shinsaku, Mayumi Tadanori, Pharmacotherapy by intracellular delivery of drugs using fusogenic liposomes: application to vaccine development, Advanced Drug Delivery Reviews, 52, 3, 2001. Crossref

  12. Kunisawa Jun, Nakanishi Tsuyoshi, Takahashi Ichiro, Okudaira Akiko, Tsutsumi Yasuo, Katayama Kazufumi, Nakagawa Shinsaku, Kiyono Hiroshi, Mayumi Tadanori, Sendai Virus Fusion Protein-Mediates Simultaneous Induction of MHC Class I/II-Dependent Mucosal and Systemic Immune Responses Via the Nasopharyngeal-Associated Lymphoreticular Tissue Immune System, The Journal of Immunology, 167, 3, 2001. Crossref

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