Published 6 issues per year
ISSN Print: 0743-4863
ISSN Online: 2162-660X
Indexed in
Polymeric Mixed Micelles: Improving the Anticancer Efficacy of Single-Copolymer Micelles
ABSTRACT
Mixed micelles self-assembled from two or more dissimilar block copolymers provide a direct and convenient approach to improved drug delivery. The present review is focused on mixed micelles (prepared from block copolymers only) for various drug delivery applications along with their merits over single-copolymer micelles. Presented are the physicochemical properties of mixed and single-copolymer micelles, various stimuli-responsive mixed micelles for the treatment of cancer, interesting combinations of multifunctional mixed micelles along with their in vitro and in vivo performance, and the potential of mixed micelles as a gene delivery system. Finally, the performance of mixed micelles in preclinical and clinical testing is explained. In addition, the interaction of mixed micelles with cancer cells and the biosafety of mixed micelles are summarized. The in vitro and in vivo performance presented here clearly reveals that the mixed-micelle approach has a wider scope than that of the single-copolymer micelle approach and directs researchers to focus on this approach to delivery of drugs/gene/biologics for various applications.
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Jiang Shanshan, Mou Yanhua, He Huiyang, Yang Dandan, Qin Li, Zhang Fang, Zhang Peng, Preparation and evaluation of self-assembly Soluplus®-sodium cholate-phospholipid ternary mixed micelles of docetaxel, Drug Development and Industrial Pharmacy, 45, 11, 2019. Crossref
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Manjappa Arehalli S., Kumbhar Popat S., Kasabe Rohini, Diwate Sonali K., Disouza John I., Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells, Future Journal of Pharmaceutical Sciences, 5, 1, 2019. Crossref
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König Nico, Willner Lutz, Lund Reidar, Structure and thermodynamics of mixed polymeric micelles with crystalline cores: tuning properties via co-assembly, Soft Matter, 15, 39, 2019. Crossref
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Kurmi Balak Das, Patel Preeti, Paliwal Rishi, Paliwal Shivani Rai, Molecular approaches for targeted drug delivery towards cancer: A concise review with respect to nanotechnology, Journal of Drug Delivery Science and Technology, 57, 2020. Crossref
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Bandgar Sandip A., Jadhav Namdeo R., Manjappa Arehalli S., A remarkable in vitro cytotoxic, cell cycle arresting and proapoptotic characteristics of low-dose mixed micellar simvastatin combined with alendronate sodium, Drug Delivery and Translational Research, 10, 4, 2020. Crossref
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Gudise Venkataiah, Chowdhury Bimalendu, Manjappa Arehalli S., Antidiabetic and antihyperlipidemic effects of Argyreia pierreana and Matelea denticulata: Higher activity of the micellar nanoformulation over the crude extract, Journal of Traditional and Complementary Medicine, 11, 3, 2021. Crossref
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Kumbhar Popat S., Sakate Asmita M., Patil Onkar B., Manjappa Arehalli S., Disouza John I., Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer, Journal of the Egyptian National Cancer Institute, 32, 1, 2020. Crossref
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Kong Haiting, Li Yiqi, Wang Duo, Liu Hong, Pan Hongchun, Physicochemical parameters and thermodynamic behavior of aprepitant/HS15 micellar system at different temperatures: Effect of electrolytes concentration, Journal of Molecular Liquids, 328, 2021. Crossref
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Gontier Alice, Renou Frédéric, Colombani Olivier, Burel Fabrice, Morandi Gaëlle, Hybridization of Poly(oxazoline) and Poly(ethylene oxide)-Based Amphiphilic Copolymers into Thermosensitive Mixed Micelles of Tunable Cloud Point, Langmuir, 37, 39, 2021. Crossref
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Mena-Giraldo Pedro, Orozco Jahir, Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery, Polymers, 13, 22, 2021. Crossref
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Patil Kiran S., Hajare Ashok A., Manjappa Arehalli S., More Harinath N., Disouza John I., Design, development, in silico and in vitro characterization of Docetaxel-loaded TPGS/ Pluronic F 108 mixed micelles for improved cancer treatment, Journal of Drug Delivery Science and Technology, 65, 2021. Crossref
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Wang Duo, Wu Mei, Zhang Wei, Pan Hongchun, Liu Hong, Effects of different sterilization cooling procedures on thermodynamic stability of Coenzyme Q10-HS15 micelles and optimization strategy: Based on micellar CMC and interface properties, Journal of Molecular Liquids, 349, 2022. Crossref
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Kancharla Samhitha, Bedrov Dmitry, Tsianou Marina, Alexandridis Paschalis, Structure and composition of mixed micelles formed by nonionic block copolymers and ionic surfactants in water determined by small-angle neutron scattering with contrast variation, Journal of Colloid and Interface Science, 609, 2022. Crossref
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Nguyen Thi Lien, Ishihara Kazuhiko, Yusa Shin-ichi, Separated Micelles Formation of pH-Responsive Random and Block Copolymers Containing Phosphorylcholine Groups, Polymers, 14, 3, 2022. Crossref
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Chowdhury Suman, Rakshit Atanu, Acharjee Animesh, Kumar Dileep, Saha Bidyut, Anionic micelles and their ideal binary mixture: Worth media for sustainable oxidation of hydrophobic alcohol, Journal of Molecular Liquids, 346, 2022. Crossref
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Pérez Sebastián E., Haidar Ziyad S., Polymeric micelles: précis for past, present and future, in Polymeric Micelles for Drug Delivery, 2022. Crossref
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Patil Smita S., Chougale Rutuja D., Manjappa Arehalli S., Disouza John I., Hajare Ashok A., Patil Kiran S., Statistically developed docetaxel-laden mixed micelles for improved therapy of breast cancer, OpenNano, 8, 2022. Crossref
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Patil Kiran S., Hajare Ashok A., Manjappa Arehalli S., More Harinath N., Disouza John I., Design, Development, In Silico, and In Vitro Characterization of Camptothecin-Loaded Mixed Micelles: In Vitro Testing of Verapamil and Ranolazine for Repurposing as Coadjuvant Therapy in Cancer, Journal of Pharmaceutical Innovation, 2022. Crossref
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Ke Zhongcheng, Shi Jianjun, Cheng Ziyang, Cheng Xiaoling, Wang Huan, Wang Meng, Wu Jingjing, Sun Yinyu, Li Changjiang, Design and characterization of gambogic acid-loaded mixed micelles system for enhanced oral bioavailability, Pharmaceutical Development and Technology, 27, 6, 2022. Crossref
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Krawczyk-Santos Anna Paula, Marreto Ricardo Neves, Concheiro Angel, Alvarez-Lorenzo Carmen, Taveira Stephânia Fleury, Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers, International Journal of Pharmaceutics: X, 4, 2022. Crossref