Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2016018537
pages 569-589

Advanced Implantable Drug Delivery Systems via Continuous Manufacturing

Mohammed Maniruzzaman
Pharmaceutics Research Lab, School of Life Sciences, University of Sussex, Sussex, UK
Ali Nokhodchi
Pharmaceutics Research Lab, School of Life Sciences, University of Sussex, Sussex, UK; Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

ABSTRACT

Polymeric implantable drug delivery systems have remarkable potential for systemic delivery of various therapeutic agents. Generally, drug-loaded implants do not require a vehicle for delivery and can be used to attain prolonged delivery into the systemic circulation of active pharmaceutical ingredients (APIs) with enhanced drug bioavailability. Furthermore, implants can provide drug release ranging from months to years, which improves patient compliance, especially for poorly bioavailable and rapidly metabolized compounds. Continuous manufacturing technology (e.g., hot-melt extrusion, or HME) has been successfully employed to prepare drug-loaded single-unit polymeric implants. Employing heat and mechanical shear, such systems retain the stability of thermolabile therapeutics (e.g., proteins) in implants. HME has emerged as important because of its varied applications that combine economic viability with solvent-free and easy scale-up processing. Moreover, it has been recognized from a quality-by-design (QbD) viewpoint by the FDA.


Articles with similar content:

Review Article: Fabricated Microparticles: An Innovative Method to Minimize the Side Effects of NSAIDs in Arthritis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 5
Shaivad Shabee Hulhasan Abadi, Afrasim Moin, Gangadharappa Hosahalli Veerabhadrappa
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Biopolymers as Transdermal Drug Delivery Systems in Dermatology Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 2
M.A. Navya, K. H. Basavaraj, Siddaramaiah, George Johnsy, R. Rashmi
Recent Advances in Self-Emulsifying Drug Delivery Systems (SEDDS)
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 2
Premjeet Singh Sandhu, Ravinder Kaur, Sarwar Beg, Bhupinder Singh, Om Parkash Katare, Rajneet Kaur Khurana
Colloidosomes: An Emerging Vesicular System in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 4
Yashwant Gupta, Satish Shilpi, Anekant Jain, Sanjay Kumar Jain