Published 6 issues per year
ISSN Print: 0743-4863
ISSN Online: 2162-660X
Indexed in
Lipid-Based Cochleates: A Promising Formulation Platform for Oral and Parenteral Delivery of Therapeutic Agents
ABSTRACT
Cochleates are lipid-based supramolecular assemblies that display great potential as delivery systems for systemic delivery of drugs, including peptides, proteins, vaccines, oligonucleotides, and genes. This is mainly attributed to their high stability and biocompatibility and their ability to deliver both hydrophilic and lipophilic drugs. Cochleates have a unique multilayered spiral structure, which is composed of a negatively charged phospholipid and a divalent cation, and can encapsulate diverse drug molecules of various shapes and sizes while minimizing toxicity associated with polymeric materials present in micro- and nanoparticle systems. This review describes current technological advances in the preparation methods, physicochemical characterization, and potential applications of cochleates as a drug delivery system for systemic delivery of various types of therapeutic agents.
-
Li Jing, Wang Xuling, Zhang Ting, Wang Chunling, Huang Zhenjun, Luo Xiang, Deng Yihui, A review on phospholipids and their main applications in drug delivery systems, Asian Journal of Pharmaceutical Sciences, 10, 2, 2015. Crossref
-
Fricker Gert, Kromp Torsten, Wendel Armin, Blume Alfred, Zirkel Jürgen, Rebmann Herbert, Setzer Constanze, Quinkert Ralf-Olaf, Martin Frank, Müller-Goymann Christel, Phospholipids and Lipid-Based Formulations in Oral Drug Delivery, Pharmaceutical Research, 27, 8, 2010. Crossref
-
Epand Raquel F., Mor Amram, Epand Richard M., Lipid complexes with cationic peptides and OAKs; their role in antimicrobial action and in the delivery of antimicrobial agents, Cellular and Molecular Life Sciences, 68, 13, 2011. Crossref
-
Czerkinsky C, Holmgren J, Topical immunization strategies, Mucosal Immunology, 3, 6, 2010. Crossref
-
Srivastava Atul, Gowda Devegowda Vishakante, Madhunapantula SubbaRao V., Shinde Chetan G., Iyer Meenakshi, Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles, APMIS, 123, 4, 2015. Crossref
-
Nagarsekar Kalpa, Ashtikar Mukul, Steiniger Frank, Thamm Jana, Schacher Felix, Fahr Alfred, Understanding cochleate formation: insights into structural development, Soft Matter, 12, 16, 2016. Crossref
-
Nagarsekar Kalpa, Ashtikar Mukul, Steiniger Frank, Thamm Jana, Schacher Felix H., Fahr Alfred, Micro-spherical cochleate composites: method development for monodispersed cochleate system, Journal of Liposome Research, 27, 1, 2017. Crossref
-
Fokina Alesya A., Chelobanov Boris P., Fujii Masayuki, Stetsenko Dmitry A., Delivery of therapeutic RNA-cleaving oligodeoxyribonucleotides (deoxyribozymes): from cell culture studies to clinical trials, Expert Opinion on Drug Delivery, 14, 9, 2017. Crossref
-
Liu Min, Zhong Xiaoming, Yang Zhiwen, Chitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A, Scientific Reports, 7, 1, 2017. Crossref
-
Batista-Duharte Alexander, Pereira Sandro Antonio, Freitas Dayvison Francis Saraiva, Fuentes Deivys Portuondo, Gutierrez-Galhardo Maria Clara, Carlos Iracilda Zeppone, Therapeutic and Prophylactic Tools for Sporotrichosis: Current Strategies and Future Tendencies, in Sporotrichosis, 2015. Crossref
-
Gamazo Carlos, Irache Juan M., Antigen Delivery Systems as Oral Adjuvants, in Molecular Vaccines, 2014. Crossref
-
Epand R. F., Sarig H., Ohana D., Papahadjopoulos-Sternberg B., Mor A., Epand R. M., Physical Properties Affecting Cochleate Formation and Morphology Using Antimicrobial Oligo-acyl-lysyl Peptide Mimetics and Mixtures Mimicking the Composition of Bacterial Membranes in the Absence of Divalent Cations, The Journal of Physical Chemistry B, 115, 10, 2011. Crossref
-
Nagarsekar Kalpa, Ashtikar Mukul, Thamm Jana, Steiniger Frank, Schacher Felix, Fahr Alfred, May Sylvio, Electron Microscopy and Theoretical Modeling of Cochleates, Langmuir, 30, 44, 2014. Crossref
-
Hudiyanti D, Al-Khafiz M F, Anam K, Encapsulation of cinnamic acid and galangal extracts in coconut (Cocos nucifera L.) liposomes, Journal of Physics: Conference Series, 1442, 1, 2020. Crossref
-
Lipa-Castro Antonio, Legrand François-Xavier, Barratt Gillian, Cochleate drug delivery systems: An approach to their characterization, International Journal of Pharmaceutics, 610, 2021. Crossref