Published 6 issues per year
ISSN Print: 0743-4863
ISSN Online: 2162-660X
Indexed in
Drug-Eluting Implants for Osteomyelitis
ABSTRACT
Osteomyelitis, an inflammatory process accompanied by bone destruction, is caused by infective microorganisms. The high success rates of antimicrobial therapy by conventional routes of administration in controlling most infectious diseases have not yet been achieved with osteomyelitis for several reasons. Local and sustained availability of drugs have proven to be more effective in achieving prophylactic and therapeutic outcomes. This review introduces osteomyelitisits prevalence and pathogenesis, the present options for drug delivery and their limitations, and the wide range of carrier materials and effective drug choices, with major focus on the pharmaceutical concepts involved in drug delivery system design and development. With increasing numbers of orthopedic surgeries and the advent of combination devices that provide support and deliver drugs, local drug delivery for osteomyelitis is a topic of importance for both social and commercial interests.
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Soundrapandian Chidambaram, Bharati Sanghamitra, Basu Debabrata, Datta Someswar, Studies on novel bioactive glasses and bioactive glass–nano-HAp composites suitable for coating on metallic implants, Ceramics International, 37, 3, 2011. Crossref
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Gimeno Marina, Pinczowski Pedro, Vázquez Francisco J., Pérez Marta, Santamaría Jesús, Arruebo Manuel, Luján Lluís, Porous orthopedic steel implant as an antibiotic eluting device: Prevention of post-surgical infection on an ovine model, International Journal of Pharmaceutics, 452, 1-2, 2013. Crossref
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Wu Tianyi, Zhang Qingchun, Ren Weiping, Yi Xiang, Zhou Zubin, Peng Xiaochun, Yu Xiaowei, Lang Meidong, Controlled release of gentamicin from gelatin/genipin reinforced beta-tricalcium phosphate scaffold for the treatment of osteomyelitis, Journal of Materials Chemistry B, 1, 26, 2013. Crossref
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Ahola Niina, Männistö Noora, Veiranto Minna, Karp Matti, Rich Jaana, Efimov Alexander, Seppälä Jukka, Kellomäki Minna, An in vitro study of composites of poly(L-lactide-co-ε-caprolactone), β-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitis, Biomatter, 3, 2, 2013. Crossref
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Soundrapandian Chidambaram, Datta Someswar, Kundu Biswanath, Basu Debabrata, Sa Biswanath, Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization, AAPS PharmSciTech, 11, 4, 2010. Crossref
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Min Jouha, Braatz Richard D., Hammond Paula T., Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier, Biomaterials, 35, 8, 2014. Crossref
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Kiryukhin Maxim V, Active drug release systems: current status, applications and perspectives, Current Opinion in Pharmacology, 18, 2014. Crossref
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Soundrapandian Chidambaram, Mahato Arnab, Kundu Biswanath, Datta Someswar, Sa Biswanath, Basu Debebrata, Development and effect of different bioactive silicate glass scaffolds: In vitro evaluation for use as a bone drug delivery system, Journal of the Mechanical Behavior of Biomedical Materials, 40, 2014. Crossref
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Kundu B., Lemos A., Soundrapandian C., Sen P. S., Datta S., Ferreira J. M. F., Basu D., Development of porous HAp and β-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system, Journal of Materials Science: Materials in Medicine, 21, 11, 2010. Crossref
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Moskowitz Joshua S., Blaisse Michael R., Samuel Raymond E., Hsu Hu-Ping, Harris Mitchel B., Martin Scott D., Lee Jean C., Spector Myron, Hammond Paula T., The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model, Biomaterials, 31, 23, 2010. Crossref
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Cabrejos-Azama Jatsue, Alkhraisat Mohammad Hamdan, Rueda Carmen, Torres Jesús, Pintado Concepción, Blanco Luis, López-Cabarcos Enrique, Magnesium substitution in brushite cements: Efficacy of a new biomaterial loaded with vancomycin for the treatment of Staphylococcus aureus infections, Materials Science and Engineering: C, 61, 2016. Crossref
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Ravelingien Matthieu, Mullens Steven, Luyten Jan, D’Hondt Matthias, Boonen Jente, De Spiegeleer Bart, Coenye Tom, Vervaet Chris, Remon Jean Paul, Vancomycin release from poly(d,l-lactic acid) spray-coated hydroxyapatite fibers, European Journal of Pharmaceutics and Biopharmaceutics, 76, 3, 2010. Crossref
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Marques C.F., Lemos A., Vieira S.I., da Cruz e Silva O.A.B., Bettencourt A., Ferreira J.M.F., Antibiotic-loaded Sr-doped porous calcium phosphate granules as multifunctional bone grafts, Ceramics International, 42, 2, 2016. Crossref
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Bharati Sanghamitra, Soundrapandian Chidambaram, Basu Debabrata, Datta Someswar, Studies on a novel bioactive glass and composite coating with hydroxyapatite on titanium based alloys: Effect of γ-sterilization on coating, Journal of the European Ceramic Society, 29, 12, 2009. Crossref
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Arruebo Manuel, Vilaboa Nuria, Santamaria Jesus, Drug delivery from internally implanted biomedical devices used in traumatology and in orthopedic surgery, Expert Opinion on Drug Delivery, 7, 5, 2010. Crossref
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Marques Catarina F., Matos Ana C., Ribeiro Isabel A. C., Gonçalves Lídia M., Bettencourt Ana, Ferreira José M. F., Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders, Journal of Materials Science: Materials in Medicine, 27, 7, 2016. Crossref
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Soundrapandian Chidambaram, Basu Debabrata, Sa Biswanath, Datta Someswar, Local drug delivery system for the treatment of osteomyelitis:In vitroevaluation, Drug Development and Industrial Pharmacy, 37, 5, 2011. Crossref
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Weisman Jeffery, Jammalamadaka Udayabhanu, Tappa Karthik, Mills David, Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices, Bioengineering, 4, 4, 2017. Crossref
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Mohan Raj R., Priya P., Raj V., Gentamicin-loaded ceramic-biopolymer dual layer coatings on the Ti with improved bioactive and corrosion resistance properties for orthopedic applications, Journal of the Mechanical Behavior of Biomedical Materials, 82, 2018. Crossref
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Tappa Karthik, Jammalamadaka Udayabhanu, Mills David K., Formulation and Evaluation of Nanoenhanced Anti-bacterial Calcium Phosphate Bone Cements, in Orthopedic Biomaterials, 2017. Crossref
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