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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v14.i3.10
13 pages

Formulation for Transfollicular Drug Administration: Some Recent Advances

Brigitte Illel
Pharmaceutical Sciences, Topical and Transdermal Dosage Forms, Sanofi Recherche, 371 rue du Pr Blayac, 34184 Montpellier Cedex 04, France

ABSTRACT

The percutaneous administration of drug products is of current therapeutic interest, mainly with regard to reduction of hepatic metabolism and systemic toxicity, and delivery to specific sites. Hair follicles and sebaceous glands can be privileged pathways for some molecules or formulations, which enter faster into these shunts than they do through the stratum corneum. The aim of this paper is to outline some examples of recent formulation methodologies that allow administration of a drug product through the follicular pathway (1) when the common, localized diseases of the pilosebaceous unit could benefit from specific delivery; and (2) to shunt the stratum corneum barrier.