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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i1.10
pages 1-26

Therapy Considerations in Drug-Eluting Stents

Jeffrey T. Ellis
Deborah L. Kilpatrick
Paul Macke Consigny
Department of Radiology, Suite 4200 Gibbon, Thomas Jefferson University Hospital, Thomas Jefferson University, 111 South 11th St., Philadelphia, PA 19107; and Department of Physiology, Jefferson Medical College, Philadelphia, PA 19107
Santosh Prabhu
Syed F. A. Hossainy
Guidant Corporation, 3200 Lakeside Drive, Mailstop S-238, Santa Clara CA 95054-2807, USA

ABSTRACT

Approximately 12 million Americans have coronary artery disease, and almost one in five deaths in the United States can be attributed to this disease. In addition, 1.2 million Americans undergo cardiac catheterization and over one-half million receive a percutaneous coronary intervention such as balloon angioplasty, atherectomy, or stent implantation annually. This article will provide an overview of (1) atherosclerosis, the progressive disease which can lead to thrombotic events and/or the development of hemodynamically significant coronary artery lesions; (2) restenosis, the reappearance of significant lesions after coronary interventions such as stent placement; and (3) drugeluting stents, the devices which, by using appropriate polymers to elute the appropriate drug with the appropriate pharmacokinetics, have almost completely eliminated restenosis.


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