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Critical Reviews™ in Therapeutic Drug Carrier Systems

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ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Current Applications of Polysaccharides in Colon Targeting

Volume 13, Issue 3-4, 1996, pp. 185-223
DOI: 10.1615/CritRevTherDrugCarrierSyst.v13.i3-4.10
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ABSTRACT

Polysaccharides have over the years been used widely in pharmaceutical, chemical, and biochemical drug delivery. This family of natural polymers has an appeal to the area of drug delivery as it is comprised of polymers with a large number of derivatizable groups, a wide range of molecular weights-, varying chemical compositions, and for the most part, a low toxicity and biodegradability, yet a high stability. The main scope of this review is to relate the polysaccharides available now to the rapidly growing field of colonic drug delivery. Polysaccharides have been applied to the area as controlled release coatings, matrices, macromolecular carriers, and biodegradable carriers. Bacterial sources of polysaccharidases as well as a detailed treatise of the enzymatic flora of the colonic region are discussed, followed by a presentation of the polysaccharides available for the purpose of colon-specific drug delivery. A final overview of the various approaches to obtain colon-specific delivery by using polysaccharides and a summary of available in vitro and in vivo testing methods will lead to the conclusion that polysaccharides at this point appear to be very promising compounds for use in obtaining colon-specific drug delivery systems.

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  1. Malafaya P.B., Elvira C., Gallardo A., San Román J., Reis R. L., Porous starch-based drug delivery systems processed by a microwave route, Journal of Biomaterials Science, Polymer Edition, 12, 11, 2001. Crossref

  2. Huang Shih-Jer, Wang Jin-Ming, Tseng Sun-Chang, Wang Li-Fang, Chen Jenn-Shing, Controlled immobilization of chondroitin sulfate in polyacrylic acid networks, Journal of Biomaterials Science, Polymer Edition, 18, 1, 2007. Crossref

  3. Krishnaiah Yellela S. R., Khan Mansoor A., Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer, Pharmaceutical Development and Technology, 17, 5, 2012. Crossref

  4. Chiu Hsin-Cheng, Hsiue Ging-Ho, Lee Yang-Ping, Huang Liang-Wei, Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, Journal of Biomaterials Science, Polymer Edition, 10, 5, 1999. Crossref

  5. Li Fei, Zhang Haitao, Gu Chunhu, Fan Li, Qiao Youbei, Tao Yangchun, Cheng Chong, Wu Hong, Yi Jun, Self-assembled nanoparticles from folate-decorated maleilated pullulan-doxorubicin conjugate for improved drug delivery to cancer cells, Polymer International, 62, 2, 2013. Crossref

  6. Chauhan Dharmarajsinh, Jani Rushiraj, Shah Shrenik, The Effect of Polysaccharide Plugs on In Vitro Release Kinetics of Drug From Pulsatile Device and Evaluation of Its In Vivo Targeting Efficiency, International Journal of Polymeric Materials, 62, 10, 2013. Crossref

  7. Mohanan P.V., Geetha C.S., Syama S., Varma H.K., Interfacing of dextran coated ferrite nanomaterials with cellular system and delayed hypersensitivity on Guinea pigs, Colloids and Surfaces B: Biointerfaces, 116, 2014. Crossref

  8. Spizzirri Umile Gianfranco, Iemma Francesca, Cirillo Giuseppe, Altimari Ilaria, Puoci Francesco, Picci Nevio, Temperature-sensitive hydrogels by graft polymerization of chitosan and N-isopropylacrylamide for drug release, Pharmaceutical Development and Technology, 18, 5, 2013. Crossref

  9. Polymer Solutions and Gels, in Surfactants and Polymers in Drug Delivery, 122, 2002. Crossref

  10. Bauer Kurt, New Experimental Coating Material for Colon-Specific Drug Delivery, in Drug Targeting Technology, 20015261, 2001. Crossref

  11. Kurosaki Tomoaki, Kitahara Takashi, Kawakami Shigeru, Nishida Koyo, Nakamura Junzo, Teshima Mugen, Nakagawa Hiroo, Kodama Yukinobu, To Hideto, Sasaki Hitoshi, The development of a gene vector electrostatically assembled with a polysaccharide capsule, Biomaterials, 30, 26, 2009. Crossref

  12. Degradation of Surfactants and Polymers in Drug Delivery, in Surfactants and Polymers in Drug Delivery, 122, 2002. Crossref

  13. Geetha C.S., Remya N.S., Leji K.B., Syama S., Reshma S.C., Sreekanth P.J., Varma H.K., Mohanan P.V., Cells–nano interactions and molecular toxicity after delayed hypersensitivity, in Guinea pigs on exposure to hydroxyapatite nanoparticles, Colloids and Surfaces B: Biointerfaces, 112, 2013. Crossref

  14. WIKBERG M., ULMIUS J., RAGNARSSON G., Review article: Targeted drug delivery in treatment of intestinal diseases, Alimentary Pharmacology & Therapeutics, 11, 2010. Crossref

  15. Amrutkar Jitendra R., Gattani Surendra G., Chitosan–Chondroitin Sulfate Based Matrix Tablets for Colon Specific Delivery of Indomethacin, AAPS PharmSciTech, 10, 2, 2009. Crossref

  16. Parayanthala Valappil Mohanan, Santhakumar Syama, Arumugam Sabareeswaran, Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats, International Journal of Biomaterials, 2014, 2014. Crossref

  17. Meissner Yvette, Lamprecht Alf, Alternative Drug Delivery Approaches for the Therapy of Inflammatory Bowel Disease, Journal of Pharmaceutical Sciences, 97, 8, 2008. Crossref

  18. Fish Neil W, Bloor John R, Drug delivery to the colon, Expert Opinion on Therapeutic Patents, 9, 11, 1999. Crossref

  19. Gbassi Gildas K., Vandamme Thierry, Probiotic Encapsulation Technology: From Microencapsulation to Release into the Gut, Pharmaceutics, 4, 1, 2012. Crossref

  20. Paolino Donatella, Sinha Piyush, Fresta Massimo, Ferrari Mauro, Drug Delivery Systems, in Encyclopedia of Medical Devices and Instrumentation, 2006. Crossref

  21. Tho Ingunn, Kleinebudde Peter, Sande Sverre Arne, Extrusion/spheronization of pectin-based formulations. I. Screening of important factors, AAPS PharmSciTech, 2, 4, 2001. Crossref

  22. Sutar Prashant B., Mishra Rakesh K., Pal Kunal, Banthia Ajit K., Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system, Journal of Materials Science: Materials in Medicine, 19, 6, 2008. Crossref

  23. Qian Junqing, Chen Xingyu, Ying Xuexiao, Lv Binfeng, Optimisation of porous starch preparation by ultrasonic pretreatment followed by enzymatic hydrolysis, International Journal of Food Science & Technology, 46, 1, 2011. Crossref

  24. Liu Lichao, Pan Xiuwei, Zhang Weian, Natural Polymer Bioconjugate Systems, in Chemistry of Bioconjugates, 2014. Crossref

  25. Wei He, Li-Fang Fan, Yong-Zhen Chang, Bai Xiang, Qing Du, Min Bai, Feng Wang, Min Qing, De-Ying Cao, Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery, Journal of Pharmacy and Pharmacology, 61, 2, 2010. Crossref

  26. Yuan Zhi-xiang, Li Jing-jing, Zhu Di, Sun Xun, Gong Tao, Zhang Zhi-rong, Enhanced accumulation of low-molecular-weight chitosan in kidneys: a study on the influence of N-acetylation of chitosan on the renal targeting, Journal of Drug Targeting, 19, 7, 2011. Crossref

  27. Patel Mayur Mahendrakumar, Drug Delivery: Oral Colon-Specific, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2015. Crossref

  28. Brayden David J, O'Mahony Daniel J, Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines, Pharmaceutical Science & Technology Today, 1, 7, 1998. Crossref

  29. Damian Festo, Van Den Mooter Guy, Samyn Celest, Kinget Renaat, In vitro biodegradation study of acetyl and methyl inulins by Bifidobacteria and inulinase, European Journal of Pharmaceutics and Biopharmaceutics, 47, 3, 1999. Crossref

  30. Sinha V.R., Kumria Rachna, Polysaccharides in colon-specific drug delivery, International Journal of Pharmaceutics, 224, 1-2, 2001. Crossref

  31. Prabaharan M., Prospective of guar gum and its derivatives as controlled drug delivery systems, International Journal of Biological Macromolecules, 49, 2, 2011. Crossref

  32. Zhang Hua, Neau Steven H., In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents, Biomaterials, 23, 13, 2002. Crossref

  33. Sinha V.R, Kumria Rachna, Microbially triggered drug delivery to the colon, European Journal of Pharmaceutical Sciences, 18, 1, 2003. Crossref

  34. Bourgeois Sandrine, Laham Antoun, Besnard Madeleine, Andremont Antoine, Fattal Elias, In vitroandin vivoevaluation of pectin beads for the colon delivery of β-lactamases, Journal of Drug Targeting, 13, 5, 2005. Crossref

  35. Yang Libo, Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora, Journal of Controlled Release, 125, 2, 2008. Crossref

  36. Zhang Hua, Alsarra Ibrahim A., Neau Steven H., An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon, International Journal of Pharmaceutics, 239, 1-2, 2002. Crossref

  37. Malmsten Martin, Bysell Helena, Hansson Per, Biomacromolecules in microgels — Opportunities and challenges for drug delivery, Current Opinion in Colloid & Interface Science, 15, 6, 2010. Crossref

  38. Gliko-Kabir Irit, Penhasi Adel, Rubinstein Abraham, Characterization of crosslinked guar by thermal analysis, Carbohydrate Research, 316, 1-4, 1999. Crossref

  39. Tuğcu-Demiröz Fatmanur, Acartürk Füsun, Takka Sevgi, Konuş-Boyunağa Öznur, In-vitroandIn-vivoEvaluation of Mesalazine–Guar Gum Matrix Tablets for Colonic Drug Delivery, Journal of Drug Targeting, 12, 2, 2004. Crossref

  40. Stubbe Barbara, Maris Bart, Van den Mooter Guy, De Smedt Stefaan C, Demeester Joseph, The in vitro evaluation of ‘azo containing polysaccharide gels’ for colon delivery, Journal of Controlled Release, 75, 1-2, 2001. Crossref

  41. Lesmes Uri, McClements David Julian, Structure–function relationships to guide rational design and fabrication of particulate food delivery systems, Trends in Food Science & Technology, 20, 10, 2009. Crossref

  42. Nadler Milabuer Mirela, Kam Yossi, Rubinstein Abraham, Orally Administered Drug Delivery Systems to the Colon, in Oral Controlled Release Formulation Design and Drug Delivery, 2010. Crossref

  43. Syama Santhakumar, Gayathri Viswanathan, Mohanan Parayanthala Valappil, Assessment of Immunotoxicity of Dextran Coated Ferrite Nanoparticles in Albino Mice, Molecular Biology International, 2015, 2015. Crossref

  44. Dahan Arik, Duvdevani Revital, Dvir Eran, Elmann Anat, Hoffman Amnon, A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: In-vivo and in-vitro evaluation of an indomethacin–lecithin conjugate, Journal of Controlled Release, 119, 1, 2007. Crossref

  45. Sharma Kashma, Kumar Vijay, Kaith Balbir Singh, Kumar Vinod, Som Sudipta, Pandey Anurag, Kalia Susheel, Swart Hendrik C., Evaluation of a conducting interpenetrating network based on gum ghatti-g-poly(acrylic acid-aniline) as a colon-specific delivery system for amoxicillin trihydrate and paracetamol, New Journal of Chemistry, 39, 4, 2015. Crossref

  46. Li Hong, Liu Yiming, Gao Xin, Li Xingang, Preparation and characterization of cassava starch-based adsorbents for separating of azeotropic ethanol-water in biofuels ethanol production, Journal of Chemical Technology & Biotechnology, 91, 4, 2016. Crossref

  47. Fetzner Axel, Böhm Stefan, Schreder Sven, Schubert Rolf, Degradation of raw or film-incorporated β-cyclodextrin by enzymes and colonic bacteria, European Journal of Pharmaceutics and Biopharmaceutics, 58, 1, 2004. Crossref

  48. Brøndsted H, Andersen C, Hovgaard L, Crosslinked dextran — a new capsule material for colon targeting of drugs, Journal of Controlled Release, 53, 1-3, 1998. Crossref

  49. Tapiero H, Mathé G, Couvreur P, Tew K.D, I. Arginine, Biomedicine & Pharmacotherapy, 56, 9, 2002. Crossref

  50. Friend David R., New oral delivery systems for treatment of inflammatory bowel disease, Advanced Drug Delivery Reviews, 57, 2, 2005. Crossref

  51. Basak Piyali, Drug Delivery Systems: Colon-Specific, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2015. Crossref

  52. Trottier Nathalie, Walker Ryan, Nutritional Aspects of Proteins, in Applied Food Protein Chemistry, 2015. Crossref

  53. Devi Nirmala, Sarmah Mandip, Khatun Bably, Maji Tarun K., Encapsulation of active ingredients in polysaccharide–protein complex coacervates, Advances in Colloid and Interface Science, 239, 2017. Crossref

  54. Cavalcanti Osvaldo Albuquerque, Mooter Guy Van den, Caramico-Soares Ida, Kinget Renaat, Polysaccharides as Excipients for Colon-Specific Coatings. Permeability and Swelling Properties of Casted Films, Drug Development and Industrial Pharmacy, 28, 2, 2002. Crossref

  55. Maculotti Katia, Tira Enrica M., Sonaggere Miriam, Perugini Paola, Conti Bice, Modena Tiziana, Pavanetto Franca, In vitroevaluation of chondroitin sulphate-chitosan microspheres as carrier for the delivery of proteins, Journal of Microencapsulation, 26, 6, 2009. Crossref

  56. Hussain M. A., Abbas K., Jantan I., Bukhari S. N. A., Polysaccharide-based materials in macromolecular prodrug design and development, International Materials Reviews, 62, 2, 2017. Crossref

  57. Oz Helieh, Ebersole Jeffrey, Application of Prodrugs to Inflammatory Diseases of the Gut, Molecules, 13, 2, 2008. Crossref

  58. Omwancha Wycliffe, Kouba Chahinaz, Yelamanchili Satish, Neau Steven H., Colon-specific drug delivery using ethylcellulose and chitosan in the coat of compression-coated tablets, Drug Development and Industrial Pharmacy, 37, 8, 2011. Crossref

  59. Bajpai S.K., Singh Surinderpal, Bajpai M., Carbohydrate Polymers: Colon-Targeted Drug Delivery, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref

  60. Gulbake Arvind, Insight to drug delivery aspects for colorectal cancer, World Journal of Gastroenterology, 22, 2, 2016. Crossref

  61. Wang L. F., Wang J. M., Chiang Y. L., Insolubilization of sodium chondroitin sulfate by forming a semi-interpenetrating polymer network with acrylic acid: A potential carrier for colon-specific drug delivery, Journal of Applied Polymer Science, 85, 1, 2002. Crossref

  62. Malik Danish J., Sokolov Ilya J., Vinner Gurinder K., Mancuso Francesco, Cinquerrui Salvatore, Vladisavljevic Goran T., Clokie Martha R.J., Garton Natalie J., Stapley Andrew G.F., Kirpichnikova Anna, Formulation, stabilisation and encapsulation of bacteriophage for phage therapy, Advances in Colloid and Interface Science, 249, 2017. Crossref

  63. Qiu Neng, Li Xuebing, Liu Junda, Application of cyclodextrins in cancer treatment, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 89, 3-4, 2017. Crossref

  64. Cassano Roberta, Nicoletta Fiore Pasquale, Mellace Silvia, Grande Fedora, Picci Nevio, Trombino Sonia, Liquid crystalline microspheres for 5-fluorouracil specific release, Journal of Drug Delivery Science and Technology, 41, 2017. Crossref

  65. Dar M. Junaid, Ali Hussain, Khan Amjad, Khan Gul Majid, Polymer-based drug delivery: the quest for local targeting of inflamed intestinal mucosa, Journal of Drug Targeting, 25, 7, 2017. Crossref

  66. Luo Zhengshan, Liu Song, Du Guocheng, Zhou Jingwen, Chen Jian, Identification of a polysaccharide produced by the pyruvate overproducer Candida glabrata CCTCC M202019, Applied Microbiology and Biotechnology, 101, 11, 2017. Crossref

  67. Jana Sougata, Maiti Sabyasachi, Jana Subrata, Stimuli-responsive guar gum composites for colon-specific drug delivery, in Biopolymer-Based Composites, 2017. Crossref

  68. Jindal Rajeev, Kaith Balbir Singh, Mittal Hemant, Rapid Synthesis of Acrylamide onto Xanthan Gum Based Hydrogels under Microwave Radiations for Enhanced Thermal and Chemical Modifications, Polymers from Renewable Resources, 2, 3, 2011. Crossref

  69. Chiu Hsin-Cheng, Hsu Yuan-Hung, Lin Pei-Jung, Synthesis of pH-sensitive inulin hydrogels and characterization of their swelling properties, Journal of Biomedical Materials Research, 61, 1, 2002. Crossref

  70. Metges Cornelia C., Contribution of Microbial Amino Acids to Amino Acid Homeostasis of the Host, The Journal of Nutrition, 130, 7, 2000. Crossref

  71. Dadou Suha M., Antonijevic Milan D., Chowdhry Babur Z., Badwan Adnan A., An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers, in Chitin-Chitosan - Myriad Functionalities in Science and Technology, 2018. Crossref

  72. Jian Hong Lei, Zhu Li Wei, Zhang Wei Ming, Qi Xiang, Jiang Jian Xin, Evaluation of Galactomannan from <i>Gleditsia Sinensis</i> Lam. as Sustained Release Material in Colonic Drug Delivery, Advanced Materials Research, 146-147, 2010. Crossref

  73. Maiti Sabyasachi, Tailored Bio-Polysaccharide Nanomicelles for Targeted Drug Delivery, in Nanoparticles' Promises and Risks, 2015. Crossref

  74. Vass Panna, Démuth Balázs, Hirsch Edit, Nagy Brigitta, Andersen Sune K., Vigh Tamás, Verreck Geert, Csontos István, Nagy Zsombor K., Marosi György, Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals, Journal of Controlled Release, 296, 2019. Crossref

  75. Hirayama Fumitoshi, Uekama Kaneto, Colonic Delivery, in Prodrugs, V, 2007. Crossref

  76. Fajardo André R., Pereira Antonio G. B., Muniz Edvani C., Hydrogels Nanocomposites Based on Crystals, Whiskers and Fibrils Derived from Biopolymers, in Eco-friendly Polymer Nanocomposites, 74, 2015. Crossref

  77. Awati Ajay, Moughan Paul J., A Role for Prebiotics in Controlled Drug Delivery, in Nanocarrier Technologies, 2006. Crossref

  78. Gabor Franz, Fillafer Christian, Neutsch Lukas, Ratzinger Gerda, Wirth Michael, Improving Oral Delivery, in Drug Delivery, 197, 2010. Crossref

  79. Hua Susan, Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors, Frontiers in Pharmacology, 11, 2020. Crossref

  80. Roy Partha Sarathi, Samanta Amalesh, Mukherjee Manabendra, Roy Bappaditya, Mukherjee Abhishek, Designing Novel pH-Induced Chitosan–Gum Odina Complex Coacervates for Colon Targeting, Industrial & Engineering Chemistry Research, 52, 45, 2013. Crossref

  81. Pu Huayin, Chen Ling, Li Xiaoxi, Xie Fengwei, Yu Long, Li Lin, An Oral Colon-Targeting Controlled Release System Based on Resistant Starch Acetate: Synthetization, Characterization, and Preparation of Film-Coating Pellets, Journal of Agricultural and Food Chemistry, 59, 10, 2011. Crossref

  82. Shaikh Mohsina, Desai Neha, Momin Munira, Bhatt Lokesh Kumar, Formulation Development and In-vitro/Ex-vivo Evaluation for a Polysaccharide-based Colon Targeted Matrix Tablet, Current Drug Delivery, 18, 10, 2021. Crossref

  83. Wang Min, Hao Wensong, Zhang Lei, Zhu Yanong, Chen Kun, Ma Shuai, Cheng Xinfeng, Zhao Jinsheng, Lipid-polymer nano core-shell type hybrid system for colon specific drug delivery, Journal of Drug Delivery Science and Technology, 63, 2021. Crossref

  84. Antosik Adrian Krzysztof, Miądlicki Piotr, Wilpiszewska Katarzyna, Markowska-Szczupak Agata, Koren Zvi C., Wróblewska Agnieszka, Polysaccharide films modified by compounds of natural origin and silver having potential medical applications, Cellulose, 28, 11, 2021. Crossref

  85. Kamguyan Khorshid, Torp Anders Meyer, Christfort Juliane Fjelrad, Guerra Priscila R., Licht Tine Rask, Hagner Nielsen Line, Zor Kinga, Boisen Anja, Colon-Specific Delivery of Bioactive Agents Using Genipin-Cross-Linked Chitosan Coated Microcontainers, ACS Applied Bio Materials, 4, 1, 2021. Crossref

  86. Wang Ming-Jun, Xie Yu-Liang, Zheng Qiao-Dong, Yao Shan-Jing, A Novel, Potential Microflora-Activated Carrier for a Colon-Specific Drug Delivery System and Its Characteristics, Industrial & Engineering Chemistry Research, 48, 11, 2009. Crossref

  87. Mehta Preeti, Kaith Balbir Singh, Green Synthesis of Agar/Gelatin Based Superabsorbent (BGCP) Through Gamma Radiation Cross-Linking Polymerization for Castoff as Sustained Drug Delivery Device and in Soil Treatment for Improved Water Retention, Journal of Polymers and the Environment, 29, 2, 2021. Crossref

  88. Hua Susan, Lye Ephraem C., Impact of gastric and bowel surgery on gastrointestinal drug delivery, Drug Delivery and Translational Research, 2022. Crossref

  89. Bourgeois Sandrine, Gernet Muriel, Pradeau Dominique, Andremont Antoine, Fattal Elias, Evaluation of critical formulation parameters influencing the bioactivity of β-lactamases entrapped in pectin beads, International Journal of Pharmaceutics, 324, 1, 2006. Crossref

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