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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

The Role of Scanning Probe Microscopy in Drug Delivery Research

Volume 13, Issue 3-4, 1996, pp. 225-256
DOI: 10.1615/CritRevTherDrugCarrierSyst.v13.i3-4.20
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ABSTRACT

The success of a drug delivery system is often dependent on the surface properties of the device. These surface properties will determine the complex dynamic interfacial events that occur when the system is introduced into the aqueous environment of a patient. Development of the scanning probe microscopes has provided a number of very powerful new surface analytical techniques that are making a significant contribution to the characterization of drug delivery systems and the interfacial processes that occur when such systems are exposed to aqueous living environments. In this review, we describe the design and attributes of these instruments and discuss the impact of the techniques on a wide range of drug delivery research. The scanning probe microscopes are providing new insights into important problems concerning drug delivery, including the molecular structure of polymeric biomaterial surfaces, the conformation of target biomolecules, the influence of morphology on biodegradation, the adsorption of proteins to synthetic surfaces, and the structure and interactions of colloidal particles. As the whole field of scanning probe microscopy continues to advance, drug delivery research is set to benefit, in the final section of the review, the future potential derived from the ability to characterize new surface properties under aqueous conditions is discussed.

CITED BY
  1. Mahlin Denny, Berggren Jonas, Alderborn Göran, Engström Sven, Moisture-Induced Surface Crystallization of Spray-Dried Amorphous Lactose Particles Studied by Atomic Force Microscopy, Journal of Pharmaceutical Sciences, 93, 1, 2004. Crossref

  2. Louey Margaret D, Mulvaney Paul, Stewart Peter J, Characterisation of adhesional properties of lactose carriers using atomic force microscopy, Journal of Pharmaceutical and Biomedical Analysis, 25, 3-4, 2001. Crossref

  3. Green Rebecca J, Frazier Richard A, Shakesheff Kevin M, Davies Martyn C, Roberts Clive J, Tendler Saul J.B, Surface plasmon resonance analysis of dynamic biological interactions with biomaterials, Biomaterials, 21, 18, 2000. Crossref

  4. Colton Richard J, Baselt David R, Dufrêne Yves F, Green John-Bruce D, Lee Gil U, Scanning probe microscopy, Current Opinion in Chemical Biology, 1, 3, 1997. Crossref

  5. Vansteenkiste S.O., Davies M.C., Roberts C.J., Tendler S.J.B., Williams P.M., Scanning probe microscopy of biomedical interfaces, Progress in Surface Science, 57, 2, 1998. Crossref

  6. Front Matter, in A Guide to Pharmaceutical Particulate Science, 2003. Crossref

  7. Gilpin R. K., Pachla L. A., Pharmaceuticals and Related Drugs, Analytical Chemistry, 71, 12, 1999. Crossref

  8. Bottomley Lawrence A., Scanning Probe Microscopy, Analytical Chemistry, 70, 12, 1998. Crossref

  9. Byrne T.M., Trussler S., McArthur M.A., Lohstreter L.B., Bai Zhijun, Filiaggi M.J., Dahn J.R., A new simple tubular flow cell for use with variable angle spectroscopic ellipsometry: A high throughput in situ protein adsorption study, Surface Science, 603, 18, 2009. Crossref

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