Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i2.20
62 pages

Poly(ethylene glycol) Conjugated Drugs and Prodrugs: A Comprehensive Review

Richard B. Greenwald
Enzon, Inc., 20 Kingsbridge Road, Piscataway, New Jersey, 08854
Charles D. Conover
Enzon, Inc., 20 Kingsbridge Road, Piscataway, New Jersey, 08854
Yun H. Choe
Enzon, Inc., 20 Kingsbridge Road, Piscataway, New Jersey, 08854

ABSTRACT

Low molecular weight Polyethylene glycol) (PEG) (< 20,000)-drug conjugates, prepared over a 20-year period, have been scrutinized and their properties and efficacy reviewed. No commercial products have thus far been reported for these types of compounds. However, during the past 5 years a renaissance in the field of PEG-(anticancer) drug conjugates has taken place, initiated by the use of higher molecular weight PEGs (> 20,000), especially 40,000, which is estimated to have a plasma circulating half-life of approximately 8-9 h. This recent resuscitation of small organic molecule delivery by high molecular weight PEG conjugates was founded on meaningful in vivo testing using established tumor models and has led to a clinical candidate. Recent applications of high molecular weight PEG prodrug strategies to amino-containing drugs are also detailed.


Articles with similar content:

Challenges in the Use of Carbon Nanotubes for Biomedical Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 2
Neelesh Kumar Mehra, Amit Kumar Jain, Narendra Kumar Jain, Neeraj Lodhi, Vaibhav Dubey, Rakesh Raj, Manoj Nahar, Dinesh Mishra
Polymeric and Lipid-Based Materials for Topical Nanoparticle Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 5
R. Jayachandra Babu, Kasturi R. Pawar
Lessons Learned from Gemcitabine: Impact of Therapeutic Carrier Systems and Gemcitabine’s Drug Conjugates on Cancer Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 1
Sathish Dyawanapelly, Animesh Kumar, Manish K. Chourasia
Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin
NEW GREEN AND THERMALLY STABLE SOLID PROPELLANT FORMULATIONS BASED ON TNEF
International Journal of Energetic Materials and Chemical Propulsion, Vol.17, 2018, issue 4
Ahmed Elbeih, Thomas M. Klapotke, Mohamed Abd-Elghany