Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v18.i6.50
40 pages

Complement Activation-Related Pseudoallergy Caused by Liposomes, Micellar Carriers of Intravenous Drugs, and Radiocontrast Agents

Janos Szebeni
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue Silver Spring, MD 20910-7580

ABSTRACT

There is growing awareness that numerous drug-induced immediate hypersensitivity reactions (HSRs) do not fit in Gell and Coombs’ Type I category of drug allergies, characterized by the pivotal pathogenic role of allergen-specific IgE. Such non-IgE-mediated “pseudoallergic” reactions are primarily caused by (1) certain liposomal formulations of intravenous drugs and imaging agents, (2) infusion liquids containing micelle-forming amphiphilic lipids or synthetic block-copolymer emulsifiers, and (3) iodinated radiocontrast media with limited solubility in water. Common features of the latter “pseudoallergens” include the capacity to activate the complement (C) system; also, the symptoms they cause are often typical manifestations of excessive anaphylatoxin generation in blood. Hence, these reactions have been called “C activation-related pseudoallergy” (CARPA). The present review surveys the experimental and clinical evidence for the involvement of C activation in HSRs caused by pseudoallergens in the above three categories. To fit CARPA within the classical scheme of HSRs, a subdivision of Type I allergy is proposed on the basis of the mechanism of mast cell (and basophil) activation. The new scheme distinguishes direct and receptor-mediated HSRs, with the latter category subdivided to true IgE-mediated allergy; anaphylatoxin-mediated CARPA; and IgE plus anaphylatoxin double-triggered reactions. Further issues addressed in the review include animal models, risk factors, laboratory predictive tests, and pharmacological prevention of CARPA.


Articles with similar content:

Autoimmune Hepatitis: Factors Involved in Initiation and Methods of Diagnosis and Treatment
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Marilina Tampoia, Franco Dammacco, Gianfranco Lauletta, Fabio Pavone, Sabino Russi, Andrea Marzullo, Domenico Sansonno
Pulsed Radiofrequency Current in the Treatment of Pain
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.23, 2011, issue 1-4
Karin Sinavsky, Naomi Betesh, Justin Hata, Steve English, Segun Dawodu, Z. David Luo, Daniel Leung, O. Jameson Stokes , Cecil DeSilva, Danielle Perret-Karimi
A Noradrenergic and Serotonergic Hypothesis of the Linkage Between Epilepsy and Affective Disorders
Critical Reviews™ in Neurobiology, Vol.13, 1999, issue 4
John W. Dailey, Phillip C. Jobe, Joe F. Wernicke
Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 3
Hnin Ei Thu, Ahmad Nazrun Shuid, Syed Nasir Abbas Bukhari, Shariza Sahudin, Endang Kumolosasi, Zahid Hussain
Paclitaxel in Cancer Treatment: Perspectives and Prospects of its Delivery Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 4
Somnath Singh, Alekha K. Dash