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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

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Polyrotaxanes: Synthesis, Structure, and Potential in Drug Delivery

Volume 16, Issue 3, 1999, pp. 289-330
DOI: 10.1615/CritRevTherDrugCarrierSyst.v16.i3.20
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ABSTRACT

This article reviews the potential of polyrotaxanes in drug delivery with the historical background of polyrotaxane syntheses. Pseudopolyrotaxanes and polyrotaxanes, including classifications, synthetic methods, structures and physical properties are discussed in the first section. The second section provides our concept of drug carriers using drug-polyrotaxane conjugates in comparison with conventional drug-polymer conjugates. The third and fourth sections describe the synthetic method for biodegradable polyrotaxanes, the conjugation with drugs, and their association under physiological conditions. The fifth section discusses other possibilities for the polyrotaxanes such as drug penetration enhancers. These studies suggest the potential of polyrotaxanes in pharmaceutical applications.

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  2. Nakama Tsuyoshi, Ooya Tooru, Yui Nobuhiko, Temperature- and pH-Controlled Hydrogelation of Poly(ethylene glycol)-Grafted Hyaluronic Acid by Inclusion Complexation with α-Cyclodextrin, Polymer Journal, 36, 4, 2004. Crossref

  3. Choi Hak Soo, Takahashi Akihiro, Ooya Tooru, Yui Nobuhiko, Molecular-Recognition and Binding Properties of Cyclodextrin-Conjugated Polyrotaxanes, ChemPhysChem, 7, 8, 2006. Crossref

  4. Watanabe Junji, Ooya Tooru, Yui Nobuhiko, Feasibility study of hydrolyzable polyrotaxanes aiming at implantable materials, Journal of Artificial Organs, 3, 2, 2000. Crossref

  5. Zhang Jianxiang, Ma Peter X., Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective, Advanced Drug Delivery Reviews, 65, 9, 2013. Crossref

  6. Ooya Tooru, Arizono Koichi, Yui Nobuhiko, Synthesis and characterization of an oligopeptide - terminated polyrotaxane as a drug carrier, Polymers for Advanced Technologies, 11, 8-12, 2000. Crossref

  7. Ooya Tooru, Yamashita Atsushi, Kurisawa Motoichi, Sugaya Yuko, Maruyama Atsushi, Yui Nobuhiko, Effects of polyrotaxane structure on polyion complexation with DNA, Science and Technology of Advanced Materials, 5, 3, 2004. Crossref

  8. Fernandes Anthony, Viterisi Aurélien, Coutrot Frédéric, Potok Stéphanie, Leigh David A., Aucagne Vincent, Papot Sébastien, Rotaxane-Based Propeptides: Protection and Enzymatic Release of a Bioactive Pentapeptide, Angewandte Chemie International Edition, 48, 35, 2009. Crossref

  9. Fernandes Anthony, Viterisi Aurélien, Coutrot Frédéric, Potok Stéphanie, Leigh David A., Aucagne Vincent, Papot Sébastien, Rotaxane-Based Propeptides: Protection and Enzymatic Release of a Bioactive Pentapeptide, Angewandte Chemie, 121, 35, 2009. Crossref

  10. Zaki Noha M., Strategies for oral delivery and mitochondrial targeting of CoQ10, Drug Delivery, 2014. Crossref

  11. van de Manakker Frank, Kroon-Batenburg Loes M. J., Vermonden Tina, van Nostrum Cornelus F., Hennink Wim E., Supramolecular hydrogels formed by β-cyclodextrin self-association and host–guest inclusion complexes, Soft Matter, 6, 1, 2010. Crossref

  12. Moon Cheol, Kwon Young Min, Lee Won Kyu, Park Yoon Jeong, Chang Li-Chien, Yang Victor C., A novel polyrotaxane-based intracellular delivery system for camptothecin:In vitro feasibility evaluation, Journal of Biomedical Materials Research Part A, 84A, 1, 2008. Crossref

  13. Ooya Tooru, Kawashima Tomokatsu, Yui Nobuhiko, Synthesis of polyrotaxane-biotin conjugates and surface plasmon resonance analysis of streptavidin recognition, Biotechnology and Bioprocess Engineering, 6, 4, 2001. Crossref

  14. Sano H, Ichi T, Kumashiro Y, Kontani K, Kuze T, Mizutani G, Ooya T, Yui N, Raman scattering study of water clusters around polyrotaxane and pseudopolyrotaxane supramolecular assemblies, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 59, 2, 2003. Crossref

  15. Wintgens Véronique, Amiel Catherine, Gene Delivery with Cyclodextrins, in Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine, 2011. Crossref

  16. Alvarez-Lorenzo Carmen, Moya-Ortega Maria D., Loftsson Thorsteinn, Concheiro Angel, Torres-Labandeira Juan J., Cyclodextrin-Based Hydrogels, in Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine, 2011. Crossref

  17. Otero-Espinar F.J., Torres-Labandeira J.J., Alvarez-Lorenzo C., Blanco-Méndez J., Cyclodextrins in drug delivery systems, Journal of Drug Delivery Science and Technology, 20, 4, 2010. Crossref

  18. Li Jia Jing, Zhao Feng, Li Jun, Polyrotaxanes for applications in life science and biotechnology, Applied Microbiology and Biotechnology, 90, 2, 2011. Crossref

  19. Higashi T., Motoyama K., Arima H., Cyclodextrin-Based Polyrotaxanes and Polypseudorotaxanes as Drug Delivery Carriers, Journal of Drug Delivery Science and Technology, 23, 6, 2013. Crossref

  20. Albuzat Thomas, Keil Manuel, Ellis James, Alexander Cameron, Wenz Gerhard, Transfection of luciferase DNA into various cells by cationic cyclodextrin polyrotaxanes derived from ionene-11, Journal of Materials Chemistry, 22, 17, 2012. Crossref

  21. Yui Nobuhiko, Ooya Tooru, Biodegradable Polymers, in Supramolecular Design for Biological Applications, 2002. Crossref

  22. Yui Nobuhiko, Ikeda Taichi, Interlocked Molecules, in Supramolecular Design for Biological Applications, 2002. Crossref

  23. Park Hyung Dal, Lee Won Kyu, Ooya Tooru, Park Ki Dong, Kim Young Ha, Yui Nobuhiko, Anticoagulant activity of sulfonated polyrotaxanes as blood-compatible materials, Journal of Biomedical Materials Research, 60, 1, 2002. Crossref

  24. Webber Matthew J., Langer Robert, Drug delivery by supramolecular design, Chemical Society Reviews, 46, 21, 2017. Crossref

  25. Erdoğar Nazlı, Varan Gamze, Varan Cem, Bilensoy Erem, Cyclodextrin-based polymeric nanosystems, in Drug Targeting and Stimuli Sensitive Drug Delivery Systems, 2018. Crossref

  26. Kim Taeyoon, Park Soo Yong, Lee Myeong-Hee, Kim Dong-Hyun, Chung Ildoo, Syntheses of polyrotaxane conjugated with 5-fluorouracil and vitamins with improved antitumor activities, Journal of Bioactive and Compatible Polymers, 34, 1, 2019. Crossref

  27. Park Hyung Dal, Lee Won Kyu, Ooya Tooru, Park Ki Dong, Kim Young Ha, Yui Nobuhiko, In vitro biocompatibility assessment of sulfonated polyrotaxane-immobilized polyurethane surfaces, Journal of Biomedical Materials Research, 66A, 3, 2003. Crossref

  28. Tooru Ooya, Nobuhiko Yui, Biodegradable Polyrotaxanes Aiming at Biomedical and Pharmaceutical Applications, in Biomedical Polymers and Polymer Therapeutics, 2002. Crossref

  29. YUI Nobuhiko, Design of Supramolecular Biomaterials Greatly Enhancing Multivalent Binding with Biological Systems, Hyomen Kagaku, 25, 1, 2004. Crossref

  30. Li Jia Jing, Zhao Feng, Li Jun, Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery, in Biofunctionalization of Polymers and their Applications, 125, 2010. Crossref

  31. Sivakumar Ponnurengam M., Peimanfard Shohreh, Zarrabi Ali, Khosravi Arezoo, Islami Matin, Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry, 20, 11, 2020. Crossref

  32. Romuald Camille, Busseron Eric, Coutrot Frédéric, Very Contracted to Extended co-Conformations with or without Oscillations in Two- and Three-Station [c2]Daisy Chains, The Journal of Organic Chemistry, 75, 19, 2010. Crossref

  33. Periasamy R., Cyclodextrin-based molecules as hosts in the formation of supramolecular complexes and their practical applications—A review, Journal of Carbohydrate Chemistry, 40, 4, 2021. Crossref

  34. Ichi Takahiro, Watanabe Junji, Ooya Tooru, Yui Nobuhiko, Controllable Erosion Time and Profile in Poly(ethylene glycol) Hydrogels by Supramolecular Structure of Hydrolyzable Polyrotaxane, Biomacromolecules, 2, 1, 2001. Crossref

  35. Ooya Tooru, Eguchi Masaru, Yui Nobuhiko, Enhanced Accessibility of Peptide Substrate toward Membrane-Bound Metalloexopeptidase by Supramolecular Structure of Polyrotaxane, Biomacromolecules, 2, 1, 2001. Crossref

  36. Ikeda Taichi, Hirota Etsuko, Ooya Tooru, Yui Nobuhiko, Thermodynamic Analysis of Inclusion Complexation between α-Cyclodextrin-Based Molecular Tube and Sodium Alkyl Sulfonate, Langmuir, 17, 1, 2001. Crossref

  37. Ulbrich Karel, Holá Kateřina, Šubr Vladimir, Bakandritsos Aristides, Tuček Jiří, Zbořil Radek, Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies, Chemical Reviews, 116, 9, 2016. Crossref

  38. Zhao Tiejun, Beckham Haskell W., Gibson Harry W., Quantitative Determination of Threading in Rotaxanated Polymers by Diffusion-Ordered NMR Spectroscopy, Macromolecules, 36, 13, 2003. Crossref

  39. Choi Hak Soo, Lee Sang Cheon, Yamamoto Kaori, Yui Nobuhiko, Block-Selective Movement of α-Cyclodextrins in Polyrotaxanes of PEI-b-PEG-b-PEI Copolymer, Macromolecules, 38, 23, 2005. Crossref

  40. Ohya Yuichi, Takamido Seigo, Nagahama Koji, Ouchi Tatsuro, Katoono Ryo, Yui Nobuhiko, Polyrotaxane Composed of Poly-l-lactide and α-Cyclodextrin Exhibiting Protease-Triggered Hydrolysis, Biomacromolecules, 10, 8, 2009. Crossref

  41. van de Manakker Frank, Vermonden Tina, van Nostrum Cornelus F., Hennink Wim E., Cyclodextrin-Based Polymeric Materials: Synthesis, Properties, and Pharmaceutical/Biomedical Applications, Biomacromolecules, 10, 12, 2009. Crossref

  42. Tuncel Dönüs, Steinke Joachim H. G., Catalytic Self-Threading:  A New Route for the Synthesis of Polyrotaxanes, Macromolecules, 37, 2, 2004. Crossref

  43. Liu Zongjian, Ye Lin, Xi Jianing, Wang Jin, Feng Zeng-guo, Cyclodextrin polymers: Structure, synthesis, and use as drug carriers, Progress in Polymer Science, 118, 2021. Crossref

  44. Yui Nobuhiko, Emerging Biomedical Functions through ‘Mobile’ Polyrotaxanes, in Supramolecular Polymer Chemistry, 2011. Crossref

  45. Eguchi Masaru, Ooya Tooru, Yui Nobuhiko, Controlling the mechanism of trypsin inhibition by the numbers of α-cyclodextrins and carboxyl groups in carboxyethylester-polyrotaxanes, Journal of Controlled Release, 96, 2, 2004. Crossref

  46. Wenz Gerhard, Han Bao-Hang, Müller Axel, Cyclodextrin Rotaxanes and Polyrotaxanes, Chemical Reviews, 106, 3, 2006. Crossref

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