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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Properties of Glycolipid-Enriched Membrane Rafts in Antigen Presentation

Volume 25, Issue 1, 2005, pp. 19-30
DOI: 10.1615/CritRevImmunol.v25.i1.20
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ABSTRACT

Presentation of antigen to T cells represents one of the central events in the engagement of the immune system toward the defense of the host against pathogens. Accordingly, understanding the mechanisms by which antigen presentation occurs is critical toward our understanding the properties of host defense against foreign antigen, as well as insight into other features of the immune system, such as autoimmune disease. The entire antigen-presentation event is complex, and many features of it remain poorly understood. However, recent studies have provided evidence showing that glycolipid-enriched membrane rafts are important for efficient antigen presentation; the studies suggest that one such function of rafts is trafficking of antigen-MHC II complexes to the presentation site on the surface of the antigen-presenting cell. Here, we present a critical discussion of rafts and their proposed functions in antigen presentation. Emerging topics of rafts and antigen presentation that warrant further investigation are also highlighted.

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  1. Cacciola Giovanna, Chianese Rosanna, Chioccarelli Teresa, Ciaramella Vincenza, Fasano Silvia, Pierantoni Riccardo, Meccariello Rosaria, Cobellis Gilda, Cannabinoids and Reproduction: A Lasting and Intriguing History, Pharmaceuticals, 3, 10, 2010. Crossref

  2. Sonnino Sandro, Mauri Laura, Chigorno Vanna, Prinetti Alessandro, Gangliosides as components of lipid membrane domains, Glycobiology, 17, 1, 2007. Crossref

  3. Nowyhed Heba N., Chandra Shilpi, Kiosses William, Marcovecchio Paola, Andary Farah, Zhao Meng, Fitzgerald Michael L., Kronenberg Mitchell, Hedrick Catherine C., ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content, Scientific Reports, 7, 1, 2017. Crossref

  4. Hauser Julian T., Lindner Robert, Coalescence of B cell receptor and invariant chain MHC II in a raft-like membrane domain, Journal of Leukocyte Biology, 96, 5, 2014. Crossref

  5. Knorr Ruth, Karacsonyi Claudia, Lindner Robert, Endocytosis of MHC molecules by distinct membrane rafts, Journal of Cell Science, 122, 10, 2009. Crossref

  6. Tu Shuyang, Zhang Haijiao, Li Yawen, Zhang Yongchao, Tian Qiang, Almásy László, Xu Xianhui, Zhang Rongguang, Zou Aihua, Li Na, Effect of Shiga Toxin on Inhomogeneous Biological Membrane Structure Determined by Small-Angle Scattering, Applied Sciences, 11, 15, 2021. Crossref

  7. Sonnino Sandro, Prinetti Alessandro, Mauri Laura, Chigorno Vanna, Tettamanti Guido, Dynamic and Structural Properties of Sphingolipids as Driving Forces for the Formation of Membrane Domains, Chemical Reviews, 106, 6, 2006. Crossref

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