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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Innate Recognition of Bacteria: Engagement of Multiple Receptors

Volume 22, Issue 4, 2002, 18 pages
DOI: 10.1615/CritRevImmunol.v22.i4.10
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Martha Triantafilou
University of Portsmouth, Institute of Biomedical and Biomolecular Sciences, School of Biological Sciences, Portsmouth; University of Essex, Department of Biological Sciences, Colchester, U.K.
Klaus Brandenburg
Forschungszentrum Borstel, Division of Biophysics, Borstel, Germany
Thomas Gutsmann
Forschungszentrum Borstel, Division of Biophysics, Borstel, Germany
Ulrich Seydel
Forschungszentrum Borstel, Division of Biophysics, Borstel, Germany
Kathy Triantafilou
University of Portsmouth, Institute of Biomedical and Biomolecular Sciences, School of Biological Sciences, Portsmouth; University of Essex, Department of Biological Sciences, Colchester, U.K.

ABSTRACT

Until recently, consensus was that the mechanism of action of the innate immune system was a simplified one. Current research findings in the field of innate recognition of bacteria suggest that it involves complex associations of receptors depending on cell type and bacterial stimuli, CD14, integrins, Toll-like receptors (TLRs), CD55, ion channels, and activation clusters containing heat shock proteins, chemokine receptor 4 and a plethora of other molecules have been shown to serve as key molecules in bacterial recognition. In this article, we review all the advances in the field and discuss the possibility that the repertoire for recognition of pathogens is defined by the combinational engagement of multiple receptors.

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  1. Wang Min, Hajishengallis George, Lipid raft-dependent uptake, signalling and intracellular fate ofPorphyromonas gingivalisin mouse macrophages, Cellular Microbiology, 10, 10, 2008. Crossref

  2. Lebeer Sarah, Vanderleyden Jos, De Keersmaecker Sigrid C. J., Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens, Nature Reviews Microbiology, 8, 3, 2010. Crossref

  3. Hajishengallis George, Toll gates to periodontal host modulation and vaccine therapy, Periodontology 2000, 51, 1, 2009. Crossref

  4. Pope Michael R., Hoffman Sara M., Tomlinson Stephen, Fleming Sherry D., Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion, Molecular Immunology, 48, 1-3, 2010. Crossref

  5. Dai Qun, Zhang Jun, Pruett Stephen B., Ethanol alters cellular activation and CD14 partitioning in lipid rafts, Biochemical and Biophysical Research Communications, 332, 1, 2005. Crossref

  6. Tichelaar Jay W., Wesselkamper Scott C., Chowdhury Supurna, Yin Hulian, Berclaz Pierre-Yves, Sartor Maureen A., Leikauf George D., Whitsett Jeffrey A., DURATION-DEPENDENT CYTOPROTECTIVE VERSUS INFLAMMATORY EFFECTS OF LUNG EPITHELIAL FIBROBLAST GROWTH FACTOR-7 EXPRESSION, Experimental Lung Research, 33, 8-9, 2007. Crossref

  7. Reinhart Konrad, Glück Thomas, Ligtenberg Jack, Tschaikowsky Klaus, Bruining Albert, Bakker Jan, Opal Steven, Moldawer Lyle L., Axtelle Tim, Turner Terence, Souza Sonia, Pribble John, CD14 receptor occupancy in severe sepsis: Results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)*, Critical Care Medicine, 32, 5, 2004. Crossref

  8. Simard Alain R., Rivest Serge, Do pathogen exposure and innate immunity cause brain diseases?, Neurological Research, 27, 7, 2005. Crossref

  9. Weber-Stadlbauer U, Epigenetic and transgenerational mechanisms in infection-mediated neurodevelopmental disorders, Translational Psychiatry, 7, 5, 2017. Crossref

  10. Zhang Xueqing, Kluger Yuval, Nakayama Yasuhiro, Poddar Ranjana, Whitney Constance, DeTora Adam, Weissman Sherman M., Newburger Peter E., Gene expression in mature neutrophils: early responses to inflammatory stimuli, Journal of Leukocyte Biology, 75, 2, 2004. Crossref

  11. van Bergenhenegouwen Jeroen, Plantinga Theo S., Joosten Leo A. B., Netea Mihai G., Folkerts Gert, Kraneveld Aletta D., Garssen Johan, Vos Arjan P., TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors, Journal of Leukocyte Biology, 94, 5, 2013. Crossref

  12. Triantafilou Kathy, Triantafilou Martha, Cell Surface Stress Proteins and the Receptor for Lipopolysaccharide, in Moonlighting Cell Stress Proteins in Microbial Infections, 7, 2013. Crossref

  13. Hajishengallis George, Krauss Jennifer L., Liang Shuang, McIntosh Megan L., Lambris John D., Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity, in Current Topics in Innate Immunity II, 946, 2012. Crossref

  14. Schromm Andra B., Howe Jörg, Ulmer Artur J., Wiesmüller Karl-Heinz, Seyberth Tobias, Jung Günther, Rössle Manfred, Koch Michel H.J., Gutsmann Thomas, Brandenburg Klaus, Physicochemical and Biological Analysis of Synthetic Bacterial Lipopeptides, Journal of Biological Chemistry, 282, 15, 2007. Crossref

  15. TRIANTAFILOU Martha, BRANDENBURG Klaus, KUSUMOTO Shoichi, FUKASE Koichi, MACKIE Alan, SEYDEL Ulrich, TRIANTAFILOU Kathy, Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses, Biochemical Journal, 381, 2, 2004. Crossref

  16. Hajishengallis George, Wang Min, Liang Shuang, Triantafilou Martha, Triantafilou Kathy, Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function, Proceedings of the National Academy of Sciences, 105, 36, 2008. Crossref

  17. Fessler Michael B., Arndt Patrick G., Frasch S. Courtney, Lieber Jonathan G., Johnson Christopher A., Murphy Robert C., Nick Jerry A., Bratton Donna L., Malcolm Kenneth C., Worthen G. Scott, Lipid Rafts Regulate Lipopolysaccharide-induced Activation of Cdc42 and Inflammatory Functions of the Human Neutrophil, Journal of Biological Chemistry, 279, 38, 2004. Crossref

  18. Hajishengallis George, Ratti Pukar, Harokopakis Evlambia, Peptide Mapping of Bacterial Fimbrial Epitopes Interacting with Pattern Recognition Receptors, Journal of Biological Chemistry, 280, 47, 2005. Crossref

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