Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Role of IFN-g in Allograft Rejection

Volume 22, Issue 4, 2002, 33 pages
DOI: 10.1615/CritRevImmunol.v22.i4.50
Get accessGet access

ABSTRACT

Interferon (IFN)-g is a cytokine produced mostly by activated T cells and NK cells that has complex effects on immune and nonimmune cells. IFN-g plays important roles in inflammation, usually in synergy with other cytokines, such as IL-1b and TNF-a. The uniqueness of IFN-g lies in its ability to induce major histocompatibility complex (MHC) expression in many tissues, making it particularly relevant to transplantation. The results of graft rejection in the absence of IFN-g show that IFN-g modulates but is not essential for the allogeneic responses, suppressing generation of CTL. In vivo IFN-g has a protective role early in the response to vascularized organ allografts: transplants in mice have a tendency to develop necrosis when IFN-g is not available, apparently by failure of the microcirculation. The lack of IFN-g greatly reduces the induction of MHC in organ allografts, and it is possible that this is indirectly related to the protective effect of IFN-g. Nevertheless IFN-g also promotes graft vessel disease later in the course of the transplant. Thus IFN-g has diverse and potentially contradictory effects on organ allograft survival, acting both on the immune system and on the graft itself, the net effect depending on the graft type and the time post-transplant.

CITED BY
  1. Sikorski Krzysztof, Czerwoniec Anna, Bujnicki Janusz M., Wesoly Joanna, Bluyssen Hans A.R., STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease, Cytokine & Growth Factor Reviews, 22, 4, 2011. Crossref

  2. Ballet Caroline, Giral Magali, Ashton-Chess Joanna, Renaudin Karine, Brouard Sophie, Soulillou Jean-Paul, Chronic rejection of human kidney allografts, Expert Review of Clinical Immunology, 2, 3, 2006. Crossref

  3. Gower R. Michael, Boehler Ryan M., Azarin Samira M., Ricci Christine F., Leonard Joshua N., Shea Lonnie D., Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression, Biomaterials, 35, 6, 2014. Crossref

  4. Pallet N., Livingston M., Dong Z., Emerging Functions of Autophagy in Kidney Transplantation, American Journal of Transplantation, 14, 1, 2014. Crossref

  5. Li Jie, Xiong Tao, Xiao Ruijing, Xiong Ali, Chen Jie, Altaf Ehtisham, Zheng Yingcheng, Zhu Guoguo, He Yuling, Tan Jinquan, Anti-CCL25 Antibody Prolongs Skin Allograft Survival by Blocking CCR9 Expression and Impairing Splenic T-Cell Function, Archivum Immunologiae et Therapiae Experimentalis, 61, 3, 2013. Crossref

  6. Zhao Zitong, Wang Lingyan, Yang Cheng, Zhao Tian, Li Long, Hu Linkun, Wu Duojiao, Rong Ruiming, Xu Ming, Zhu Tongyu, Soluble FGL2 induced by tumor necrosis factor-α and interferon-γ in CD4+ T cells through MAPK pathway in human renal allograft acute rejection, Journal of Surgical Research, 184, 2, 2013. Crossref

  7. van den Boogaardt Daniëlle E. M., van Miert Paula P. M. C., de Vaal Yvonne J. H., de Fijter Johan W., Claas Frans H. J., Roelen Dave L., The Ratio of Interferon-γ and Interleukin-10 Producing Donor-Specific Cells as an In Vitro Monitoring Tool for Renal Transplant Patients, Transplantation, 82, 6, 2006. Crossref

  8. Hidalgo Luis G., Urmson Joan, Halloran Philip F., IFN-gamma Decreases CTL Generation by Limiting IL-2 Production: A Feedback Loop Controlling Effector Cell Production, American Journal of Transplantation, 5, 4, 2005. Crossref

  9. Sis B., Famulski K. S., Allanach K. L., Zhu L.-F., Halloran P. F., IFN-? Prevents Early Perforin-Granzyme-Mediated Destruction of Kidney Allografts by Inducing Donor Class I Products in the Kidney, American Journal of Transplantation, 7, 10, 2007. Crossref

  10. Kraaij Marina D., Vereyken Elly J.F., Leenen Pieter J.M., van den Bosch Thierry P.P., Rezaee Farhad, Betjes Michiel G.H., Baan Carla C., Rowshani Ajda T., Human monocytes produce interferon-gamma upon stimulation with LPS, Cytokine, 67, 1, 2014. Crossref

  11. Lee Hyeon II, Kim Mee Kum, Oh Joo Youn, Ko Jung Hwa, Lee Hyun Ju, Wee Won Ryang, Lee Jin Hak, Galα(1-3)Gal expression of the cornea in vitro, in vivo and in xenotransplantation, Xenotransplantation, 14, 6, 2007. Crossref

  12. Hoerbelt Ruediger, Benjamin Christopher L., Shoji Tsuyoshi, Houser Stuart L., Muniappan Ashok, Hasse Rebecca S., Ledgerwood Levi G., Allan James S., Sachs David H., Madsen Joren C., The Effects of Tolerance on Allograft Damage Caused by the Innate Immune System, Transplantation, 85, 3, 2008. Crossref

  13. Xu H., Huang Y., Hussain L. R., Zhu Z., Bozulic L. D., Ding C., Yan J., Ildstad S. T., Sensitization to Minor Antigens Is a Significant Barrier in Bone Marrow Transplantation and Is Prevented by CD154:CD40 Blockade, American Journal of Transplantation, 10, 7, 2010. Crossref

  14. Pallet Nicolas, Emerging Roles of Autophagy in the Stressed Kidney Allograft, Seminars in Nephrology, 34, 1, 2014. Crossref

  15. Famulski K. S., Einecke G., Reeve J., Ramassar V., Allanach K., Mueller T., Hidalgo L. G., Zhu L.-F., Halloran P. F., Changes in the Transcriptome in Allograft Rejection: IFN-gamma-Induced Transcripts in Mouse Kidney Allografts, American Journal of Transplantation, 6, 6, 2006. Crossref

  16. Famulski K. S., Sis B., Billesberger L., Halloran P. F., Interferon-γ and Donor MHC Class I Control Alternative Macrophage Activation and Activin Expression in Rejecting Kidney Allografts: A Shift in the Th1-Th2 Paradigm, American Journal of Transplantation, 8, 3, 2008. Crossref

  17. Rosenblum Joshua M., Zhang Qi-Wei, Siu Gerald, Collins Tassie L., Sullivan Timothy, Dairaghi Daniel J., Medina Julio C., Fairchild Robert L., CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-Producing Effectors and Prolongs Allograft Survival, Transplantation, 87, 3, 2009. Crossref

  18. Ladhoff Juliane, Bader Michael, Brösell Sabine, Effenberger Elke, Westermann Dirk, Volk Hans-Dieter, Seifert Martina, Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells, Cell Research, 19, 4, 2009. Crossref

  19. Sikorski Krzysztof, Chmielewski Stefan, Olejnik Adam, Wesoly Joanna Z., Heemann Uwe, Baumann Marcus, Bluyssen Hans, STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction, JAK-STAT, 1, 4, 2012. Crossref

  20. Günther Oliver P., Balshaw Robert F., Scherer Andreas, Hollander Zsuzsanna, Mui Alice, Triche Timothy J., Freue Gabriela Cohen, Li Guiyun, Ng Raymond T., Wilson-McManus Janet, McMaster W Robert, McManus Bruce M., Keown Paul A., Functional Genomic Analysis of Peripheral Blood During Early Acute Renal Allograft Rejection, Transplantation, 88, 7, 2009. Crossref

  21. KleinJan Alex, Willart Monique A. M., Kuipers Harmjan, Coyle Anthony J., Hoogsteden Henk C., Lambrecht Bart N., Inducible Costimulator Blockade Prolongs Airway Luminal Patency in a Mouse Model of Obliterative Bronchiolitis, Transplantation, 86, 10, 2008. Crossref

  22. Mengel Michael, Renalomics, Surgical Pathology Clinics, 7, 3, 2014. Crossref

  23. Colvin Robert B., Smith R. Neal, Antibody-mediated organ-allograft rejection, Nature Reviews Immunology, 5, 10, 2005. Crossref

  24. Canossi A., Piazza A., Poggi E., Ozzella G., Di Rocco M., Papola F., Iaria G., Adorno D., Renal Allograft Immune Response Is Influenced by Patient and Donor Cytokine Genotypes, Transplantation Proceedings, 39, 6, 2007. Crossref

  25. Fukami Naohiko, Subramanian Vijay, Angaswamy Nataraju, Liu Wei, Mohanakumar T., Hoshinaga Kiyotaka, Mizoribine—An inosine monophosphate dehydrogenase inhibitor—acts synergistically with cyclosporine A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier, Transplant Immunology, 26, 2-3, 2012. Crossref

  26. El-Sawy Tarek, Miura Masayoshi, Fairchild Robert, Early T Cell Response to Allografts Occuring Prior to Alloantigen Priming Up-Regulates Innate-Mediated Inflammation and Graft Necrosis, The American Journal of Pathology, 165, 1, 2004. Crossref

  27. Bedi Damanpreet S., Krenzien Felix, Quante Markus, Uehara Hirofumi, Edtinger Karoline, Liu Guangxiang, Denecke Christian, Jurisch Anke, Kim Irene, Li Hongmei, Yuan Xiaodong, Ge Xupeng, ElKhal Abdallah, Tullius Stefan G., Defective CD8 Signaling Pathways Delay Rejection in Older Recipients, Transplantation, 100, 1, 2016. Crossref

  28. Belperio John A., Keane Michael P., Strieter Robert M., Cytokines during the pathogenesis of bronchiolitis obliterans syndrome, Current Opinion in Organ Transplantation, 8, 3, 2003. Crossref

  29. Lu Ying, Waller Edmund K., Dichotomous Role of Interferon-γ in Allogeneic Bone Marrow Transplant, Biology of Blood and Marrow Transplantation, 15, 11, 2009. Crossref

  30. Bradley Benjamin A., Prognostic assays for rejection and tolerance in organ transplantation, Transplant Immunology, 14, 3-4, 2005. Crossref

  31. Karakhanova Svetlana, Oweira Hani, Steinmeyer Beate, Sachsenmaier Milena, Jung Gregor, Elhadedy Hazem, Schmidt Jan, Hartwig Werner, Bazhin Alexandr V., Werner Jens, Interferon-γ, interleukin-10 and interferon-inducible protein 10 (CXCL10) as serum biomarkers for the early allograft dysfunction after liver transplantation, Transplant Immunology, 34, 2016. Crossref

  32. Hall Bruce M., Tran Giang T., Robinson Catherine M., Hodgkinson Suzanne J., Induction of antigen specific CD4+CD25+Foxp3+T regulatory cells from naïve natural thymic derived T regulatory cells, International Immunopharmacology, 28, 2, 2015. Crossref

  33. Romagnani Paola, Crescioli Clara, CXCL10: A candidate biomarker in transplantation, Clinica Chimica Acta, 413, 17-18, 2012. Crossref

  34. Sikorski Krzysztof, Wesoly Joanna, Bluyssen Hans, Data Mining of Atherosclerotic Plaque Transcriptomes Predicts STAT1-Dependent Inflammatory Signal Integration in Vascular Disease, International Journal of Molecular Sciences, 15, 8, 2014. Crossref

  35. Larocca Rafael Assumpção, Moraes-Vieira Pedro Manoel, Bassi Ênio José, Semedo Patrícia, de Almeida Danilo Candido, da Silva Marina Burgos, Thornley Thomas, Pacheco-Silva Alvaro, Câmara Niels Olsen Saraiva, Rameshwar Pranela, Adipose Tissue-Derived Mesenchymal Stem Cells Increase Skin Allograft Survival and Inhibit Th-17 Immune Response, PLoS ONE, 8, 10, 2013. Crossref

  36. Matz Mareen, Lorkowski Christine, Fabritius Katharina, Wu Kaiyin, Rudolph Birgit, Frischbutter Stefan, Brakemeier Susanne, Gaedeke Jens, Neumayer Hans-H., Mashreghi Mir-Farzin, Budde Klemens, The selective biomarker IL-8 identifies IFTA after kidney transplantation in blood cells, Transplant Immunology, 39, 2016. Crossref

  37. Cova Emanuela, Inghilleri Simona, Pandolfi Laura, Morosini Monica, Magni Sara, Colombo Miriam, Piloni Davide, Finetti Chiara, Ceccarelli Gabriele, Benedetti Laura, Cusella Maria Gabriella, Agozzino Manuela, Corsi Fabio, Allevi Raffaele, Mrakic-Sposta Simona, Moretti Sarah, De Gregori Simona, Prosperi Davide, Meloni Federica, Bioengineered gold nanoparticles targeted to mesenchymal cells from patients with bronchiolitis obliterans syndrome does not rise the inflammatory response and can be safely inhaled by rodents, Nanotoxicology, 11, 4, 2017. Crossref

  38. Win Thet Su, Murakami Naoka, Borges Thiago J., Chandraker Anil, Murphy George, Lian Christine, Barrera Victor, Ho Sui Shannan, Schoenfeld David, Teague Jessica, Bueno Ericka, Tullius Stefan G., Pomahac Bohdan, Clark Rachael A., Riella Leonardo V., Longitudinal immunological characterization of the first presensitized recipient of a face transplant, JCI Insight, 2, 13, 2017. Crossref

  39. Besançon Alix, Demir Zeynep, Goncalves Tania, Valette Fabrice, Panafieu Emilie, Chatenoud Lucienne, You Sylvaine, Differential Impact of T-bet and IFNγ on Pancreatic Islet Allograft Rejection, Transplantation, 102, 9, 2018. Crossref

  40. Zhao Xiangli, Zhang Kai, Daniel Peter, Wisbrun Natali, Fuchs Hendrik, Fan Hua, Delayed allogeneic skin graft rejection in CD26-deficient mice, Cellular & Molecular Immunology, 16, 6, 2019. Crossref

  41. Yin Yuxin, Reed Elaine F., Zhang Qiuheng, Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing, Scientific Reports, 9, 1, 2019. Crossref

  42. Baldwin William M., Valujskikh Anna, Lalli Peter N., Fairchild Robert L., The Immune Response to Transplanted Organs, in Kidney and Pancreas Transplantation, 2011. Crossref

  43. Brzoska T., Luger T. A., Murine Models of Atopic Dermatitis, in Animal Models of T Cell-Mediated Skin Diseases, 50, 2005. Crossref

  44. Fougeray Sophie, Mami Iadh, Bertho Gildas, Beaune Philippe, Thervet Eric, Pallet Nicolas, Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy, The Journal of Immunology, 189, 6, 2012. Crossref

  45. Rosenblum Joshua M., Shimoda Naohiko, Schenk Austin D., Zhang Howard, Kish Danielle D., Keslar Karen, Farber Joshua M., Fairchild Robert L., CXC Chemokine Ligand (CXCL) 9 and CXCL10 Are Antagonistic Costimulation Molecules during the Priming of Alloreactive T Cell Effectors, The Journal of Immunology, 184, 7, 2010. Crossref

  46. Burman Angela C., Banovic Tatjana, Kuns Rachel D., Clouston Andrew D., Stanley Amanda C., Morris Edward S., Rowe Vanessa, Bofinger Helen, Skoczylas Renae, Raffelt Neil, Fahy Olivier, McColl Shaun R., Engwerda Christian R., McDonald Kelli P. A., Hill Geoffrey R., IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract, Blood, 110, 3, 2007. Crossref

  47. Zareei Neda, Miri Hamid Reza, Karimi Mohammad Hossein, Afshari Afsoon, Geramizadeh Bita, Roozbeh Jamshid, Yaghobi Ramin, Increasing of the interferon-γ gene expression during polyomavirus BK infection in kidney transplant patients, Microbial Pathogenesis, 129, 2019. Crossref

  48. Udomkarnjananun Suwasin, Kerr Stephen J., Townamchai Natavudh, van Besouw Nicole M., Hesselink Dennis A., Baan Carla C., Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis, Clinical Biochemistry, 94, 2021. Crossref

  49. Li Chuan, Phoon Yee Peng, Karlinsey Keaton, Tian Ye F., Thapaliya Samjhana, Thongkum Angkana, Qu Lili, Matz Alyssa Joyce, Cameron Mark, Cameron Cheryl, Menoret Antoine, Funchain Pauline, Song Jung-Min, Diaz-Montero C. Marcela, Tamilselvan Banumathi, Golden Jackelyn B., Cartwright Michael, Rodriguez Annabelle, Bonin Christopher, Vella Anthony, Zhou Beiyan, Gastman Brian R., A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients, Journal of Experimental Medicine, 219, 1, 2022. Crossref

  50. Taqueti Viviany R., Mitchell Richard N., Lichtman Andrew H., PROTECTING THE PUMP: Controlling Myocardial Inflammatory Responses, Annual Review of Physiology, 68, 1, 2006. Crossref

  51. Sarrazin Stéphane, Bonnaffé David, Lubineau André, Lortat-Jacob Hugues, Heparan Sulfate Mimicry, Journal of Biological Chemistry, 280, 45, 2005. Crossref

  52. Arad Tal, Fainstein Nina, Goldfarb Smadar, Lachish Marva, Ganz Tal, Ben-Hur Tamir, CD200 -dependent and -independent immune-modulatory functions of neural stem cells, Stem Cell Research, 56, 2021. Crossref

  53. Szyda Joanna, Dobosz Paula, Stojak Joanna, Sypniewski Mateusz, Suchocki Tomasz, Kotlarz Krzysztof, Mroczek Magdalena, Stępień Maria, Słomian Dawid, Butkiewicz Sławomir, Sztromwasser Paweł, Liu Jakub, Król Zbigniew J., Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?, International Journal of Molecular Sciences, 23, 11, 2022. Crossref

  54. Mendoza Rojas Aleixandra, Hesselink Dennis A., van Besouw Nicole M., Dieterich Marjolein, de Kuiper Ronella, Baan Carla C., van Gelder Teun, High Tacrolimus Intrapatient Variability and Subtherapeutic Immunosuppression are Associated With Adverse Kidney Transplant Outcomes, Therapeutic Drug Monitoring, 44, 3, 2022. Crossref

  55. Chruscinski Andrzej, Rojas-Luengas Vanessa, Moshkelgosha Sajad, Issachar Assaf, Luo Jane, Yowanto Handy, Lilly Leslie, Smith Robert, Renner Eberhard, Zhang Jianhua, Epstein Maor, Grant David, McEvoy Caitriona M, Konvalinka Ana, Humar Atul, Adeyi Oyedele, Fischer Sandra, Volmer Felix H, Taubert Richard, Jaeckel Elmar, Juvet Stephen, Selzner Nazia, Levy Gary A, Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial, Clinical and Experimental Immunology, 207, 1, 2022. Crossref

  56. Tzeng Yuan-Sheng, Peng Yi-Jen, Tang Shih-En, Huang Kun-Lun, Chu Shi-Jye, Wu Shu-Yu, Cheng Chia-Pi, Intermittent Exposure of Hypercapnia Suppresses Allograft Rejection via Induction of Treg Differentiation and Inhibition of Neutrophil Accumulation, Biomedicines, 10, 4, 2022. Crossref

  57. El Helou Guy, Jay Colleen, Nunez Marina, Hepatitis C virus and kidney transplantation: Recent trends and paradigm shifts, Transplantation Reviews, 36, 1, 2022. Crossref

  58. Silva Rafael Cardoso Maciel Costa, Panis Carolina, Pires Bruno Ricardo Barreto, Lessons from transmissible cancers for immunotherapy and transplant, Immunological Medicine, 45, 3, 2022. Crossref

  59. Shimoyama Koichiro, Tsuchiya Tomoshi, Watanabe Hironosuke, Ergalad Abdelmotagaly, Iwatake Mayumi, Miyazaki Takuro, Hashimoto Yasumasa, Hsu Yu-I., Hatachi Go, Matsumoto Keitaro, Ishii Mitsutoshi, Mizoguchi Satoshi, Doi Ryoichiro, Tomoshige Koichi, Yamaoka Tetsuji, Nagayasu Takeshi, Donor and Recipient Adipose-Derived Mesenchymal Stem Cell Therapy for Rat Lung Transplantation, Transplantation Proceedings, 2022. Crossref

  60. Zhang Kunli, Huang Qiuyan, Peng Laru, Lin Sen, Liu Jie, Zhang Jianfeng, Li Chunling, Zhai Shaolun, Xu Zhihong, Wang Sutian, The multifunctional roles of autophagy in the innate immune response: Implications for regulation of transplantation rejection, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

Forthcoming Articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain