Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
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Which Immune Cells Matter? The Immunopathogenesis of Multiple Sclerosis
ABSTRACT
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.
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Claes Nele, Fraussen Judith, Stinissen Piet, Hupperts Raymond, Somers Veerle, B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: Insights from Therapeutic Interventions, Frontiers in Immunology, 6, 2015. Crossref
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Maltby Vicki E., Graves Moira C., Lea Rodney A., Benton Miles C., Sanders Katherine A., Tajouri Lotti, Scott Rodney J., Lechner-Scott Jeannette, Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients, Clinical Epigenetics, 7, 1, 2015. Crossref
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Bos S. D., Berge T., Celius E. G., Harbo H. F., From genetic associations to functional studies in multiple sclerosis, European Journal of Neurology, 23, 5, 2016. Crossref
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TAHA SAFA, ALJISHI MUNA, ALSHAROQI ISA, BAKHIET MOIZ, Differential upregulation of the hypothetical transmembrane protein 66 (TMEM66) in multiple sclerosis patients with potential inflammatory response, Biomedical Reports, 3, 1, 2015. Crossref
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Peeters Liesbet M., Vanheusden Marjan, Somers Veerle, Van Wijmeersch Bart, Stinissen Piet, Broux Bieke, Hellings Niels, Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression, Frontiers in Immunology, 8, 2017. Crossref
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