Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v21.i5.10
28 pages

Macrophage Arginine Metabolism to Ornithine/Urea or Nitric Oxide/Citrulline: A Life or Death Issue

Charles D. Mills
Department of Surgery and Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota Hospitals and Clinics, Box 120, 420 Delaware St. SE, Minneapolis, MN 55455

ABSTRACT

Macrophages can metabolize arginine to nitric oxide in quantities that inhibit pathogens or nearby host cells. They can instead metabolize arginine to ornithine (a precursor of polyamines and collagen) in quantities that stimulate pathogens or nearby host cells. Macrophages are essentially the only circulating cells that can make these life or death decisions with arginine. Macrophages expressing these destructive or constructive phenotypes have been termed M-1 or M-2 because they also stimulate TH1 or TH2 responses, respectively. Factors that influence whether a macrophage expresses the M-1 or M-2 phenotype and the real or potential impact on immune responses and other host processes are discussed.


Articles with similar content:

The Role of Antigen Presentation in Tumor-Associated Macrophages
Critical Reviews™ in Immunology, Vol.40, 2020, issue 3
Richard J. Stopforth, Elizabeth Sally Ward
Acquisition of MHC-Specific Receptors on Murine Natural Killer Cells
Critical Reviews™ in Immunology, Vol.23, 2003, issue 4
Brian T. Wilhelm, Dixie L. Mager, Fumio Takei, Linnea L. Veinotte
Lipopolysaccharide Binding Protein Participation in Cellular Activation by LPS
Critical Reviews™ in Immunology, Vol.15, 1995, issue 3-4
R. L. Simmons, G. L. Su, S. C. Wang
Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 2
Loreana Sanches Silveira, Barbara de Moura Mello Antunes, José Cesar Rosa Neto, Ronaldo Vagner Thomatieli dos Santos, Fábio Santos Lira, Andre Luis Araujo Minari
Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases
Critical Reviews™ in Immunology, Vol.36, 2016, issue 2
Nicole Baumgarth, Trang T. T. Nguyen