Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells
ABSTRACT
CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.
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Khan Masood A., Sriram Venkataraman, Renukaradhya Gourapura J., Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., Apoptosis-induced inhibition of CD1d-mediated antigen presentation: different roles for caspases and signal transduction pathways, Immunology, 125, 1, 2008. Crossref
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Nishio Shoji, Yamada Naoko, Ohyama Hideki, Yamanegi Koji, Nakasho Keiji, Hata Masaki, Nakamura Yoshiteru, Fukunaga Satoru, Futani Hiroyuki, Yoshiya Shinichi, Ueda Haruyasu, Taniguchi Masaru, Okamura Haruki, Terada Nobuyuki, Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of α-galactosylceramide and interleukin-18, Cancer Science, 2007. Crossref
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Renukaradhya Gourapura J., Khan Masood A., Vieira Marcus, Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma, Blood, 111, 12, 2008. Crossref
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Brutkiewicz Randy R., Willard Claire A., Gillett-Heacock Kristin K., Pawlak M. Robert, Bailey Jennifer C., Khan Masood A., Nagala Manjula, Du Wenjun, Gervay-Hague Jacquelyn, Renukaradhya Gourapura J., Protein kinase C δ is a critical regulator of CD1d-mediated antigen presentation, European Journal of Immunology, 37, 9, 2007. Crossref
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Lin Yinling, Roberts Tonya J., Wang Chyung-Ru, Cho Sungyoo, Brutkiewicz Randy?R., Long-term loss of canonical NKT cells following an acute virus infection, European Journal of Immunology, 35, 3, 2005. Crossref
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Sriram Venkataraman, Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., Cell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells, European Journal of Immunology, 35, 6, 2005. Crossref
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Renukaradhya Gourapura J., Sriram Venkataraman, Du Wenjun, Gervay-Hague Jacquelyn, Van Kaer Luc, Brutkiewicz Randy R., Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma modelin vivo, International Journal of Cancer, 118, 12, 2006. Crossref
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Webb Tonya J. Roberts, Litavecz Roberta A., Khan Masood A., Du Wenjun, Gervay-Hague Jacquelyn, Renukaradhya Gourapura J., Brutkiewicz Randy R., Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules, European Journal of Immunology, 36, 10, 2006. Crossref
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Nowicki Marek J., Vigen Cheryl, Mack Wendy J., Seaberg Eric, Landay Alan, Anastos Kathryn, Young Mary, Minkoff Howard, Greenblatt Ruth, Levine Alexandra M., Association of Cells with Natural Killer (NK) and NKT Immunophenotype with Incident Cancers in HIV-Infected Women, AIDS Research and Human Retroviruses, 24, 2, 2008. Crossref
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Xing Guo-Wen, Wu Douglass, Poles Michael A., Horowitz Amir, Tsuji Moriya, Ho David D., Wong Chi-Huey, Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/β-galactosylceramides, Bioorganic & Medicinal Chemistry, 13, 8, 2005. Crossref
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Lalazar Gadi, Ya'acov Ami Ben, Livovsky Dan M., El Haj Madi, Pappo Orit, Preston Sarah, Zolotarov Lidya, Ilan Yaron, β-Glycoglycosphingolipid-Induced Alterations of the STAT Signaling Pathways Are Dependent on CD1d and the Lipid Raft Protein Flotillin-2, The American Journal of Pathology, 174, 4, 2009. Crossref
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Cho Sungyoo, Knox Kenneth S., Kohli Lisa M., He Johnny J., Exley Mark A., Wilson S. Brian, Brutkiewicz Randy R., Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex, Virology, 337, 2, 2005. Crossref
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Wei Chun-Yu, Ko Tai-Ming, Shen Chen-Yang, Chen Yuan-Tsong, A Recent Update of Pharmacogenomics in Drug-induced Severe Skin Reactions, Drug Metabolism and Pharmacokinetics, 27, 1, 2012. Crossref
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Shintani Masaki, Mitsunaga Fusako, Shimabukuro Shun, Nakamura Shin, Anti-Inflammatory and Immunostimulatory Effects of Extract from Culture of Effective Microorganisms (ECEM) Revealed by Functional Genomics and Metabolome Analyses, Food and Nutrition Sciences, 06, 12, 2015. Crossref
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Gourapura Renukaradhya J., Khan Masood A., Gallo Richard M., Shaji Daniel, Liu Jianyun, Brutkiewicz Randy R., Sandberg Johan K., Forming a Complex with MHC Class I Molecules Interferes with Mouse CD1d Functional Expression, PLoS ONE, 8, 8, 2013. Crossref
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Lin Yinling, Roberts Tonya J., Spence Philip M., Brutkiewicz Randy R., Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection, Journal of Leukocyte Biology, 77, 2, 2005. Crossref
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Liu Jianyun, Gallo Richard M., Khan Masood A., Iyer Abhirami K., Kratzke Ian M., Brutkiewicz Randy R., JNK2 modulates the CD1d‐dependent and ‐independent activation of iNKT cells, European Journal of Immunology, 49, 2, 2019. Crossref
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Liu Jianyun, Shaji Daniel, Cho Sungyoo, Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., A Threonine-Based Targeting Signal in the Human CD1d Cytoplasmic Tail Controls Its Functional Expression, The Journal of Immunology, 184, 9, 2010. Crossref
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Gallo Richard M., Khan Masood A., Shi Jianjian, Kapur Reuben, Wei Lei, Bailey Jennifer C., Liu Jianyun, Brutkiewicz Randy R., Regulation of the Actin Cytoskeleton by Rho Kinase Controls Antigen Presentation by CD1d, The Journal of Immunology, 189, 4, 2012. Crossref
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Bogdanov Mikhail, Mileykovskaya Eugenia, Dowhan William, Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders, in Lipids in Health and Disease, 49, 2008. Crossref
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Liu Jianyun, Renukaradhya Gourapura J., Brutkiewicz Randy R., The Regulation of CD1d+ and CD1d− Tumors by NKT Cells, in Natural Killer T cells, 2012. Crossref
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Wang Zheng-Yu, Kusam Saritha, Munugalavadla Veerendra, Kapur Reuben, Brutkiewicz Randy R., Dent Alexander L., Regulation of Th2 Cytokine Expression in NKT Cells: Unconventional Use of Stat6, GATA-3, and NFAT2, The Journal of Immunology, 176, 2, 2006. Crossref
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Khan Masood A., Gallo Richard M., Renukaradhya Gourapura J., Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., Statins Impair CD1d-Mediated Antigen Presentation through the Inhibition of Prenylation, The Journal of Immunology, 182, 8, 2009. Crossref
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Renukaradhya Gourapura J., Webb Tonya J. Roberts, Khan Masood A., Lin Yin Ling, Du Wenjun, Gervay-Hague Jacquelyn, Brutkiewicz Randy R., Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK, The Journal of Immunology, 175, 7, 2005. Crossref
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Sharma Manju, Zhang Shuangmin, Niu Liang, Lewinsohn David M., Zhang Xiang, Huang Shouxiong, Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses, Frontiers in Immunology, 11, 2020. Crossref
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Lalazar Gadi, Ben Ya'acov Ami, Eliakim-Raz Noa, Livovsky Dan M., Pappo Orit, Preston Sarah, Zolotarov Lidya, Ilan Yaron, β-Glycosphingolipids-mediated lipid raft alteration is associated with redistribution of NKT cells and increased intrahepatic CD8+ T lymphocyte trapping, Journal of Lipid Research, 49, 9, 2008. Crossref
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Khan Masood Alam, Khan Arif, Role of NKT Cells during Viral Infection and the Development of NKT Cell-Based Nanovaccines, Vaccines, 9, 9, 2021. Crossref
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Ilan Y, Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?, Clinical and Experimental Immunology, 158, 3, 2009. Crossref
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Oshansky Christine M, Zhang Wenliang, Moore Elizabeth, Tripp Ralph A, The host response and molecular pathogenesis associated with respiratory syncytial virus infection, Future Microbiology, 4, 3, 2009. Crossref
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Renukaradhya Gourapura J., Khan Masood A., Shaji Daniel, Brutkiewicz Randy R., Vesicular Stomatitis Virus Matrix Protein Impairs CD1d-Mediated Antigen Presentation through Activation of the p38 MAPK Pathway, Journal of Virology, 82, 24, 2008. Crossref
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Parker April Keim, Parker Scott, Yokoyama Wayne M., Corbett John A., Buller R. Mark L., Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection, Journal of Virology, 81, 8, 2007. Crossref
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Berzofsky Jay A., Howe Savannah B., Olkhanud Purevdorj B., Antigens, in Encyclopedia of Infection and Immunity, 2022. Crossref
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Ilyinskii Petr O., Wang Ruojie, Balk Steven P., Exley Mark A., CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo, Journal of Virology, 80, 14, 2006. Crossref
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Broxmeyer Hal E., Dent Alexander, Cooper Scott, Hangoc Giao, Wang Zheng-Yu, Du Wenjun, Gervay-Haque Jacquelyn, Sriram Venkataraman, Renukaradhya Gourapura J., Brutkiewicz Randy R., A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus, Experimental Hematology, 35, 4, 2007. Crossref
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Khan Masood A., Gallo Richard M., Brutkiewicz Randy R., Anthrax Lethal Toxin Impairs CD1d-Mediated Antigen Presentation by Targeting the Extracellular Signal-Related Kinase 1/2 Mitogen-Activated Protein Kinase Pathway, Infection and Immunity, 78, 5, 2010. Crossref
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Khan Masood Alam, Malik Ajamaluddin, Alruwetei Abdulmohsen M., Alzohairy Mohammad A., Alhatlani Bader Y., Al Rugaie Osamah, Alhumaydhi Fahad A., Khan Arif, Delivery of MERS antigen encapsulated in α-GalCer-bearing liposomes elicits stronger antigen-specific immune responses, Journal of Drug Targeting, 30, 8, 2022. Crossref