Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016017062
pages 149-161

Gene Therapy for Rheumatoid Arthritis

Shuang Liu
Department of Pharmacology, Ehime University Graduate School of Medicine, Shitsugawa, Toon-shi, Ehime 791-0295, Japan
Kazutaka Maeyama
Department of Pharmacology, Ehime University Graduate School of Medicine, Shitsugawa, Toon-shi, Ehime 791-0295, Japan

ABSTRACT

With the aim of controlling disease relapse and bone deformation of individual joints, the application of gene therapy in rheumatoid arthritis (RA) has slowly progressed on a trial-and-error basis. Several new therapeutic targets have been identified in preclinical studies in animal models, although a limited number of gene-based clinical trials have been conducted. In this article, we summarize the status of gene therapy for RA by addressing issues related to innovating drug development. More disease- and target-specific preclinical tests are required to overcome the insufficient information regarding pharmacokinetics and toxicokinetics, which are related to safety issues in the field of RA gene therapy.


Articles with similar content:

Src Kinase Inhibitors: Promising Cancer Therapeutics?
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 2
Valerie G . Brunton, Helen Creedon
Cannabinoid/Opioid Crosstalk in the Central Nervous System
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 1&2
Jorge Manzanares, Jose A. Fuentes, Javier Corchero
Progress Toward Skeletal Gene Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Henry J. Klamut, Shin-Tai Chen, David J. Baylink, K.-H. William Lau
Emerging Immunotherapies for Cancer and Their Potential for Application in Pediatric Oncology
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 3-4
Crystal L. Mackall, Rimas J. Orentas
Diagnostic, Prognostic, and Therapeutic Potencies of Circulating miRNAs in Acute Myocardial Infarction
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 4
Farshad Mirzavi, Seyed Mahdi Hassanian Mehr, Seyed Isaac Hashemy, Kiarash Ghazvini, Safieh Ebrahimi