Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Recognition of Melanoma-Derived Antigens by CTL: Possible Mechanisms Involved in Down-Regulating Anti-Tumor T-Cell Reactivity
ABSTRACT
Several T cell-recognized epitopes presented by melanoma cells have been identified recently. Despite the large array of epitopes potentially available for clinical use, it is still unclear which of these antigens could be effective in mediating anti-tumor responses when used as a vaccine. Preliminary studies showed that immunization of melanoma patients with epitopes derived from proteins of the MAGE family may result in significant clinical regressions. However, no sign of systemic immunization could be observed in peripheral blood of treated patients. Conversely, significant immunization (detected as increased antigen-specific CTL activity in peripheral blood) was obtained by vaccinating HLA-A2.1+ melanoma patients with the immunodominant epitope (residues 27-35) of the differentiation antigen MART-1, but this immunization was not accompanied by a significant clinical response. To implement immunotherapeuties capable of significantly impacting disease outcome, it is necessary to identify the potential mechanisms responsible for the failure of some antigens to mediate significant anti-tumor responses in vivo. In the case of the MART-127.35 epitope, we hypothesize that one of these mechanisms may be related to the existence of natural analogs of this peptide in other human normal proteins.
-
Somasundaram Rajasekharan, Robbins Paul, Moonka Dilip, Loh Elwyn, Marincola Francesco, Patel Amy, Guerry DuPont, Herlyn Dorothee, CD4+, HLA class I-restricted, cytolytic T-lymphocyte clone against primary malignant melanoma cells, International Journal of Cancer, 85, 2, 2000. Crossref
-
Noy Roy, Eppel Malka, Haus-Cohen Maya, Klechevsky Einav, Mekler Orian, Michaeli Yael, Denkberg Galit, Reiter Yoram, T-cell receptor-like antibodies: novel reagents for clinical cancer immunology and immunotherapy, Expert Review of Anticancer Therapy, 5, 3, 2005. Crossref
-
Rivoltini Licia, Carrabba Matteo, Huber Veronica, Castelli Chiara, Novellino Luisa, Dalerba Piero, Mortarini Roberta, Arancia Giuseppe, Anichini Andrea, Fais Stefano, Parmiani Giorgio, Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction, Immunological Reviews, 188, 1, 2002. Crossref
-
Jantscheff Peter, Herrmann Richard, Rochlitz Christoph, Cancer gene and immunotherapy: recent developments, Medical Oncology, 16, 2, 1999. Crossref
-
Rivoltini Licia, Canese Paola, Huber Veronica, Iero Manuela, Pilla Lorenzo, Valenti Roberta, Fais Stefano, Lozupone Francesco, Casati Chiara, Castelli Chiara, Parmiani Giorgio, Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control?, Expert Opinion on Biological Therapy, 5, 4, 2005. Crossref
-
Nemunaitis John, Fong Timothy, Shabe Peter, Martineau Darlene, Ando Dale, Comparison of Serum Interleukin-10 (IL-10) Levels Between Normal Volunteers and Patients with Advanced Melanoma, Cancer Investigation, 19, 3, 2001. Crossref
-
Hudson Amy R., Smoller Bruce R., IMMUNOHISTOCHEMISTRY IN DIAGNOSTIC DERMATOPATHOLOGY, Dermatologic Clinics, 17, 3, 1999. Crossref
-
Nielsen Mai-Britt, Kirkin Alexei F, Loftus Douglas, Nissen Mogens Holst, Rivoltini Licia, Zeuthen Jesper, Geisler Carsten, Odum Niels, Amino Acid Substitutions in the Melanoma Antigen Recognized by T Cell 1 Peptide Modulate Cytokine Responses in Melanoma-Specific T Cells, Journal of Immunotherapy, 23, 4, 2000. Crossref
-
Rivoltini Licia, Parmiani Giorgio, Carrabba Matteo, Pilla Lorenzo, Altered peptide ligands of tumor T-cell epitopes, in Tumor Antigens Recognized by T Cells and Antibodies, 2003. Crossref
-
Tyutyunyk-Massey Liliya, Haqqani Syed U., Mandava Reshma, Kentiba Kirubel, Dammalapati Mallika, Dao Nga, Haueis Joshua, Gewirtz David, Landry Joseph W., , 138, 2018. Crossref
-
J�ger Elke, H�hn Hanni, Karbach Julia, Momburg Frank, Castelli Chiara, Knuth Alexander, Seliger Barbara, Maeurer Markus J., Cytotoxic T lymphocytes define multiple peptide isoforms derived from the melanoma-associated antigen MART-1/Melan-A, International Journal of Cancer, 81, 6, 1999. Crossref
-
Denkberg Galit, Lev Avital, Eisenbach Lea, Benhar Itai, Reiter Yoram, Selective Targeting of Melanoma and APCs Using a Recombinant Antibody with TCR-Like Specificity Directed Toward a Melanoma Differentiation Antigen, The Journal of Immunology, 171, 5, 2003. Crossref
-
Kurnick James T., Ramirez-Montagut Teresa, Boyle Lenora A., Andrews David M., Pandolfi Franco, Durda Paul J., Butera David, Dunn Ian S., Benson Elizabeth M., Gobin Sam J. P., van den Elsen Peter J., A Novel Autocrine Pathway of Tumor Escape from Immune Recognition: Melanoma Cell Lines Produce a Soluble Protein That Diminishes Expression of the Gene Encoding the Melanocyte Lineage Melan-A/MART-1 Antigen Through Down-Modulation of Its Promoter, The Journal of Immunology, 167, 3, 2001. Crossref
-
Castelli Chiara, Rivoltini Licia, Andreola Giovanna, Carrabba Matteo, Renkvist Nicolina, Parmiani Giorgio, T‐cell recognition of melanoma‐associated antigens, Journal of Cellular Physiology, 182, 3, 2000. Crossref
-
Ramirez-Montagut T, Andrews D M, Ihara A, Pervaiz S, Pandolfi F, Van Den Elsen P J, Waitkus R, Boyle L A, Hishii M, Kurnick J T, Melanoma antigen recognition by tumour-infiltrating T lymphocytes (TIL): effect of differential expression of Melan-A/MART-1, Clinical and Experimental Immunology, 119, 1, 2002. Crossref
-
Asai Tadao, Storkus Walter J., Whiteside Theresa L., Evaluation of the Modified ELISPOT Assay for Gamma Interferon Production in Cancer Patients Receiving Antitumor Vaccines, Clinical Diagnostic Laboratory Immunology, 7, 2, 2000. Crossref
-
Denkberg Galit, Cohen Cyril J., Lev Avital, Chames Patrick, Hoogenboom Hennie R., Reiter Yoram, Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity, Proceedings of the National Academy of Sciences, 99, 14, 2002. Crossref
-
Kono Michihiro, Dunn Ian S., Durda Paul J., Butera David, Rose Lenora B., Haggerty Timothy J., Benson Elizabeth M., Kurnick James T., Role of the Mitogen-Activated Protein Kinase Signaling Pathway in the Regulation of Human Melanocytic Antigen Expression, Molecular Cancer Research, 4, 10, 2006. Crossref