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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Toll-like Receptor Modulation in Head and Neck Cancer

Volume 28, Issue 3, 2008, pp. 201-213
DOI: 10.1615/CritRevImmunol.v28.i3.20
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ABSTRACT

Toll-like receptors (TLRs) are the archetypal pattern recognition receptors that have emerged as key mediators of immune functions. Activation of TLRs is a first line of defense of the immune system, leading to the activation and recruitment of different types of immune cells to sites of infection and malignant cell growth. Cells of human cancers, such as head and neck squamous cell carcinoma (HNSCC), are known to develop numerous molecular strategies to escape from efficient antitumor immune responses. It is supposed that tumor production of various immunosuppressive mediators contributes to impaired and altered immune functions in cancer patients. The molecular mechanisms responsible for these immunomodulatory processes and the biosynthesis of the immunosuppressive HNSCC microenvironment remain mostly unknown. Recently, different studies have shown that tumor cells are able to modulate the expression and function of TLR proteins in different kinds of immune cells. In this review, we present recent progress in these studies on the modulation of TLR expression and signaling through malignant head and neck cancer.

CITED BY
  1. Starska K, Forma E, Bryś M, Głowacka E, Lewy-Trenda I, Łukomski M, Krajewska WM, The expression of TLR pathway molecules in peripheral blood mononuclear cells and their relationship with tumor invasion and cytokine secretion in laryngeal carcinoma, Advances in Medical Sciences, 57, 1, 2012. Crossref

  2. Meyer Christian, Pries Ralph, Wollenberg Barbara, Established and novel NF-κB inhibitors lead to downregulation of TLR3 and the proliferation and cytokine secretion in HNSCC, Oral Oncology, 47, 9, 2011. Crossref

  3. Ruan Min, Zhang Zun, Li Siyi, Yang Wenjun, Wang Lizheng, Zhang Chenping, Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma, Archives of Oral Biology, 56, 9, 2011. Crossref

  4. Rich Alison Mary, Hussaini Haizal Mohd, Parachuru Venkata P. B., Seymour Gregory J., Toll-Like Receptors and Cancer, Particularly Oral Squamous Cell Carcinoma, Frontiers in Immunology, 5, 2014. Crossref

  5. Wulff Sandra, Pries Ralph, Wollenberg Barbara, Cytokine release of human NK cells solely triggered with Poly I:C, Cellular Immunology, 263, 2, 2010. Crossref

  6. Echarri María, Lopez-Martin Ana, Hitt Ricardo, Targeted Therapy in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (LA-R/M HNSCC), Cancers, 8, 3, 2016. Crossref

  7. Duray Anaëlle, Demoulin Stéphanie, Hubert Pascale, Delvenne Philippe, Saussez Sven, Immune Suppression in Head and Neck Cancers: A Review, Clinical and Developmental Immunology, 2010, 2010. Crossref

  8. Tsuchiya Masa, Piras Vincent, Choi Sangdun, Akira Shizuo, Tomita Masaru, Giuliani Alessandro, Selvarajoo Kumar, Sommer Peter, Emergent Genome-Wide Control in Wildtype and Genetically Mutated Lipopolysaccarides-Stimulated Macrophages, PLoS ONE, 4, 3, 2009. Crossref

  9. Klein Johanna C., Wild Clarissa A., Lang Stephan, Brandau Sven, Differential immunomodulatory activity of tumor cell death induced by cancer therapeutic toll-like receptor ligands, Cancer Immunology, Immunotherapy, 65, 6, 2016. Crossref

  10. Fu Qiu , Maniar Amudhan, Quevedo Diaz Marco, Chapoval Andrei I, Medvedev Andrei E, Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors, Innate Immunity, 17, 4, 2011. Crossref

  11. Langevin Scott, Kuhnell Damaris, Parry Tess, Biesiada Jacek, Huang Shouxiong, Wise-Draper Trisha, Casper Keith, Zhang Xiang, Medvedovic Mario, Kasper Susan, Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cellsin vitroreveals common secretion profiles and potential utility as salivary biomarkers, Oncotarget, 8, 47, 2017. Crossref

  12. López-Ozuna Vanessa M., Gupta Ishita, Kiow Ryan Liu Chen, Matanes Emad, Kheraldine Hadeel, Yasmeen Amber, Khalil Ashraf, Vranic Semir, Al Moustafa Ala-Eddin, Farsi Halema F Al, Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis, Toxics, 8, 3, 2020. Crossref

  13. Moreira Dayson, Sampath Sagus, Won Haejung, White Seok Voon, Su Yu-Lin, Alcantara Marice, Wang Chongkai, Lee Peter, Maghami Ellie, Massarelli Erminia, Kortylewski Marcin, Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity, Journal of Clinical Investigation, 131, 2, 2021. Crossref

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