Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Role of Peroxisome Proliferator-Activated Receptor g and Its Ligands in the Control of Immune Responses
ABSTRACT
To ensure that efficient immune responses against dangerous antigens are raised while tolerance to self molecules is preserved, the immune system tightly regulates activation and survival of its cellular compartments through mechanisms only partially characterized. In this context, recent evidence indicates a role in immunity of the nuclear receptor PPAR-g, which is upregulated in activated lymphocytes and in dendritic cells. Preliminary in vitro studies indicate that PPAR-g activation profoundly alters the immune properties of these cells, usually leading to the inhibition of immune responses. Naturally occurring PPAR-g ligands include the cyclopentenone prostaglandins of the J series, which are present in bone marrow, thymus, and secondary lymphatic tissues. The levels of these metabolites are increased in inflamed tissues, where they exert strong anti-inflammatory effects leading to resolution of inflammation and wound healing. Cyclopentenone prostaglandins activate both PPAR-g–dependent and PPAR-g–independent pathways, possess intrinsic proapoptotic potential and are direct inhibitors of NF-kB signaling. The relevance of these effects in vivo still awaits proper evaluation in humans. Some of the newly described regulatory pathways might eventually be exploited in the treatment of immune diseases by means of PPAR-g ligands, such as thiazolidinediones or prostaglandins.
-
Lutzow Ylva Strandberg, Gray Christian, Tellam Ross, 15-Deoxy-Δ12,14-prostaglandin J2induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells, Journal of Dairy Research, 75, 1, 2008. Crossref
-
Maroof Asher, English Nicholas R., Bedford Penelope A., Gabrilovich Dmitry I., Knight Stella C., Developing dendritic cells become 'lacy' cells packed with fat and glycogen, Immunology, 115, 4, 2005. Crossref
-
Rinaldi Barbara, Pieri Laura, Donniacuo Maria, Cappetta Donato, Capuano Annalisa, Domenici Lola, Carnuccio Rosa, Romagnoli Paolo, Filippelli Amelia, Rossi Francesco, ROSIGLITAZONE REDUCES THE INFLAMMATORY RESPONSE IN A MODEL OF VASCULAR INJURY IN RATS, Shock, 32, 6, 2009. Crossref
-
Jenkins Stephen J., Allen Judith E., Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes, Journal of Biomedicine and Biotechnology, 2010, 2010. Crossref
-
Lloyd-Smith Mariann, Sheffield-Brotherton Bro, Children's Environmental Health: Intergenerational Equity in Action-A Civil Society Perspective, Annals of the New York Academy of Sciences, 1140, 1, 2008. Crossref
-
Kwon Yong-Jin, Chung Soo-Jin, Kim Tae-Yeon, Park Min-Chan, Peroxisome Proliferator-activated Receptor-γ Agonist Inhibits Pro-inflammatory Gene Expressions and Cellular Proliferation of Fibroblast Like Synoviocytes from Patients with Rheumatoid Arthritis by Down-regulation of NF-kappaB, The Journal of the Korean Rheumatism Association, 17, 2, 2010. Crossref
-
Wei‐guo Zhu, Hui Yan, Shan Li, Yun Zhang, Wen‐cheng Nie, Fu‐lin Yu, Fang‐yan Fan, Jun‐hua Ge, Jian‐hua Zhu, PPAR‐γ agonist inhibits Ang II‐induced activation of dendritic cells via the MAPK and NF‐κB pathways, Immunology & Cell Biology, 88, 3, 2010. Crossref
-
Phulwani Nirmal K., Feinstein Douglas L., Gavrilyuk Vitaliy, Akar Candan, Kielian Tammy, 15-deoxy-?12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-?-independent pathway, Journal of Neurochemistry, 99, 5, 2006. Crossref
-
Panzer U., Zahner G., Wienberg U., Steinmetz O. M., Peters A., Turner J.-E., Paust H.-J., Wolf G., Stahl R. A. K., Schneider A., 15-Deoxy- 12,14-prostaglandin J2 inhibits INF- -induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells, Nephrology Dialysis Transplantation, 23, 12, 2008. Crossref
-
Ramos G C, Fernandes D, Charão C T, Souza D G, Teixeira M M, Assreuy J, Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo , British Journal of Pharmacology, 151, 6, 2007. Crossref
-
Baken Kirsten A., van Loveren Henk, Pennings Jeroen L. A., de Vries Annemieke, Breit Timo M., van Steeg Harry, Gene Expression Profiling of Bis(tri-n-butyltin)oxide (TBTO)-Induced Immunotoxicity in Mice and Rats, Journal of Immunotoxicology, 3, 4, 2006. Crossref
-
Bouaboula Monsif, Hilairet Sandrine, Marchand Jean, Fajas Lluis, Fur Gerard Le, Casellas Pierre, Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation, European Journal of Pharmacology, 517, 3, 2005. Crossref
-
Rampino Teresa, Ranghino Andrea, Guidetti Cristina, Gregorini Marilena, Soccio Grazia, Marasà Maddalena, Libetta Carmelo, Guida Gianenrico, De Amici Mara, Dal Canton Antonio, Activation of PPARγ enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes, Transplant Immunology, 18, 1, 2007. Crossref
-
Paz Otero M., Santín Efrén Pérez, Rodríguez-Barrios Fátima, Vaz Belén, de Lera Ángel R., Selective, potent PPARγ agonists with cyclopentenone core structure, Bioorganic & Medicinal Chemistry Letters, 19, 7, 2009. Crossref
-
Raikwar Himanshu P., Muthian Gladson, Rajasingh Johnson, Johnson Caroline, Bright John J., PPARγ antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis, Journal of Neuroimmunology, 167, 1-2, 2005. Crossref
-
Boissonneault Gilbert, Dietary Fat, Immunity, and Inflammatory Disease, in Fatty Acids in Foods and their Health Implications,Third Edition, 20073230, 2007. Crossref
-
Ariel Amiram, Timor Orly, Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis, The Journal of Pathology, 229, 2, 2013. Crossref
-
Feinstein D.L., Spagnolo A., Akar C., Weinberg G., Murphy P., Gavrilyuk V., Russo C. Dello, Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?, Biochemical Pharmacology, 70, 2, 2005. Crossref
-
Bobryshev Yuri V., Monocyte recruitment and foam cell formation in atherosclerosis, Micron, 37, 3, 2006. Crossref
-
Reddy Aravind T., Lakshmi Sowmya P., Reddy Raju C., The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice, PPAR Research, 2012, 2012. Crossref
-
Baldwin Albert, NF-_B and IKK as Key Mediators of Inflammation andOncogenic Progression, in Handbook of Transcription Factor NF-kappaB, 2006. Crossref
-
Yin Yan, Hou Gang, Li Er-ran, Wang Qiu-yue, Kang Jian, Regulation of cigarette smoke-induced toll-like receptor 4 expression by peroxisome proliferator-activated receptor-gamma agonists in bronchial epithelial cells, Respirology, 18, 2013. Crossref
-
Bieniek Jared, Childress Chandra, Swatski Matthew D., Yang Wannian, COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins, The Prostate, 74, 10, 2014. Crossref
-
Pujol-Autonell Irma, Ampudia Rosa-Maria, Planas Raquel, Marin-Gallen Silvia, Carrascal Jorge, Sanchez Alex, Marin Ana, Puig-Domingo Manuel, Pujol-Borrell Ricardo, Verdaguer Joan, Vives-Pi Marta, Pietropaolo Massimo, Efferocytosis Promotes Suppressive Effects on Dendritic Cells through Prostaglandin E2 Production in the Context of Autoimmunity, PLoS ONE, 8, 5, 2013. Crossref
-
Zhu Weiguo, Yan Hui, Li Shan, Nie Wencheng, Fan Fangyan, Zhu Jianhua, PPAR-γ agonist pioglitazone regulates dendritic cells immunogenicity mediated by DC-SIGN via the MAPK and NF-κB pathways, International Immunopharmacology, 41, 2016. Crossref
-
Vakrakou Aigli G., Polyzos Alexandros, Kapsogeorgou Efstathia K., Thanos Dimitris, Manoussakis Menelaos N., Impaired anti-inflammatory activity of PPARγ in the salivary epithelia of Sjögren's syndrome patients imposed by intrinsic NF-κB activation, Journal of Autoimmunity, 86, 2018. Crossref
-
Han ShouWei, Ritzenthaler Jeffrey D., Rivera Hilda N., Roman Jesse, Peroxisome proliferator-activated receptor-γ ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1, American Journal of Physiology-Lung Cellular and Molecular Physiology, 289, 3, 2005. Crossref
-
Chen Fang, Ghosh Arijit, Hu Mei, Long Yan, Sun Hongbin, Kong Lingyi, Hong Hao, Tang Susu, RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model, Neurotoxicity Research, 33, 2, 2018. Crossref
-
Yuan Guang-Jin, Zhang Ming-Liang, Gong Zuo-Jiong, Effects of PPARg agonist pioglitazone on rat hepatic fibrosis, World Journal of Gastroenterology, 10, 7, 2004. Crossref
-
Reddy Aravind T., Lakshmi Sowmya P., Banno Asoka, Reddy Raju C., Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress, Free Radical Biology and Medicine, 126, 2018. Crossref
-
Liu Di, Chi Shuyan, Tan Beiping, Dong Xiaohui, Yang Qihui, Liu Hongyu, Zhang Shuang, Han Fenglu, He Yuanfa, Effects of fish oil with difference oxidation degree on growth performance and expression abundance of antioxidant and fat metabolism genes in orange spotted grouper,Epinephelus coioides, Aquaculture Research, 50, 1, 2019. Crossref
-
Arizmendi Narcy, Hou Chenjie, Guo Fujiang, Li Yiming, Kulka Marianna, Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells, International Journal of Immunopathology and Pharmacology, 32, 2018. Crossref
-
Iruretagoyena Mirentxu I., Sepúlveda Sofía E., Lezana J. Pablo, Hermoso Marcela, Bronfman Miguel, Gutiérrez Miguel A., Jacobelli Sergio H., Kalergis Alexis M., Inhibition of Nuclear Factor-κB Enhances the Capacity of Immature Dendritic Cells to Induce Antigen-Specific Tolerance in Experimental Autoimmune Encephalomyelitis, Journal of Pharmacology and Experimental Therapeutics, 318, 1, 2006. Crossref
-
Brys Lea, Beschin Alain, Raes Geert, Ghassabeh Gholamreza Hassanzadeh, Noël Wim, Brandt Jef, Brombacher Frank, Baetselier Patrick De, Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection, The Journal of Immunology, 174, 10, 2005. Crossref
-
Daniel Vino, Anti-Inflammatory Activity, in Drug Discovery and Evaluation: Pharmacological Assays, 2016. Crossref
-
Zhang Xia, Rodriguez-Galán Maria Cecilia, Subleski Jeff J., Ortaldo John R., Hodge Deborah L., Wang Ji-Ming, Shimozato Osamu, Reynolds Della A., Young Howard A., Peroxisome proliferator-activated receptor-γ and its ligands attenuate biologic functions of human natural killer cells, Blood, 104, 10, 2004. Crossref
-
Vogel Hans Gerhard, Analgesic, Anti-inflammatory, and Anti-pyretic Activity, in Drug Discovery and Evaluation, 2007. Crossref
-
Friedmann Peter, Cooper Hywel, Healy Eugene, Peroxisome Proliferator‐activated Receptors and their Relevance to Dermatology, Acta Dermato-Venereologica, 85, 3, 2005. Crossref
-
Daniel Vino, Anti-inflammatory Activity, in Drug Discovery and Evaluation: Pharmacological Assays, 2014. Crossref
-
Franco-Pons N., Folch-Puy E., Closa D., Systemic Inflammatory Effects of Acute Pancreatitis; Effects of Lipid Mediators, in Pancreatology, 2009. Crossref
-
Deng Yongbing, Jiang Xue, Deng Xiaoyan, Chen Hong, Xu Jie, Zhang Zhaosi, Liu Geli, Yong Zhu, Yuan Chengfu, Sun Xiaochuan, Wang Changdong, Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway, Genes & Diseases, 7, 2, 2020. Crossref
-
Reddy Aravind T., Lakshmi Sowmya P., Kleinhenz Jennifer M., Sutliff Roy L., Hart C. Michael, Reddy Raju C., Endothelial Cell Peroxisome Proliferator–Activated Receptor γ Reduces Endotoxemic Pulmonary Inflammation and Injury, The Journal of Immunology, 189, 11, 2012. Crossref
-
Panati Kalpana, Subramani Parasuraman Aiya, Reddy Madhusudhana M., Derangula Madhavi, Arva Tatireddigari Venkat R.R., Kolliputi Narasaiah, Narala Venkata Ramireddy, The nitrated fatty acid, 10-nitrooleate inhibits the neutrophil chemotaxis via peroxisome proliferator-activated receptor gamma in CLP-induced sepsis in mice, International Immunopharmacology, 72, 2019. Crossref
-
Appel Silke, Mirakaj Valdete, Bringmann Anita, Weck Markus M., Grünebach Frank, Brossart Peter, PPAR-γ agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-κB pathways, Blood, 106, 12, 2005. Crossref
-
Mamber Stephen W., Gurel Volkan, Lins Jeremy, Ferri Fred, Beseme Sarah, McMichael John, Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD), Journal of Cannabis Research, 2, 1, 2020. Crossref
-
Appel Silke, Rupf Anette, Weck Markus M., Schoor Oliver, Brümmendorf Tim H., Weinschenk Toni, Grünebach Frank, Brossart Peter, Effects of Imatinib on Monocyte-Derived Dendritic Cells Are Mediated by Inhibition of Nuclear Factor-κB and Akt Signaling Pathways, Clinical Cancer Research, 11, 5, 2005. Crossref
-
Tajbakhsh Amir, Farahani Najmeh, Gheibihayat Sayed Mohammad, Mirkhabbaz Amir Masoud, Savardashtaki Amir, Hamblin Michael R., Mirzaei Hamed, Autoantigen-specific immune tolerance in pathological and physiological cell death: Nanotechnology comes into view, International Immunopharmacology, 90, 2021. Crossref
-
Febbraio Maria, Guy Ella, Silverstein Roy L., Stem Cell Transplantation Reveals That Absence of Macrophage CD36 Is Protective Against Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 12, 2004. Crossref
-
Thurnher Martin, Putz Thomas, Gander Hubert, Rahm Andrea, Bartsch Georg, Ramoner Reinhold, The cyclopentenone prostaglandin PGA2 costimulates the maturation of human dendritic cells, Experimental Hematology, 33, 2, 2005. Crossref
-
Lakshmi Sowmya P., Reddy Aravind T., Zhang Yingze, Sciurba Frank C., Mallampalli Rama K., Duncan Steven R., Reddy Raju C., Down-regulated Peroxisome Proliferator-activated Receptor γ (PPARγ) in Lung Epithelial Cells Promotes a PPARγ Agonist-reversible Proinflammatory Phenotype in Chronic Obstructive Pulmonary Disease (COPD), Journal of Biological Chemistry, 289, 10, 2014. Crossref