Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
The Role of the Proto-Oncogene c-myc in B Lymphocyte Differentiation
ABSTRACT
Since the discovery of the myc gene, few genes are likely to have such influence on biomedical research. The diversity of the biological functions regulated by this transcription factor and its impact in human health have attracted investigators from many different fields. The development of conditional knockout mouse models has allowed for the characterization of Myc-driven molecular mechanisms in primary cells in physiological and pathological conditions. In this review, we discuss some of the main functions and recent findings regarding c-Myc in in vivo B lymphocyte differentiation from early progenitors to terminally differentiated cells.
-
Edmunds Lia R., Otero P. Anthony, Sharma Lokendra, D’Souza Sonia, Dolezal James M., David Sherin, Lu Jie, Lamm Lauren, Basantani Mahesh, Zhang Pili, Sipula Ian J., Li Lucy, Zeng Xuemei, Ding Ying, Ding Fei, Beck Megan E., Vockley Jerry, Monga Satdarshan P. S., Kershaw Erin E., O’Doherty Robert M., Kratz Lisa E., Yates Nathan A., Goetzman Eric P., Scott Donald, Duncan Andrew W., Prochownik Edward V., Abnormal lipid processing but normal long-term repopulation potential of myc−/− hepatocytes, Oncotarget, 7, 21, 2016. Crossref
-
Campion Eva M., Hakimjavadi Roya, Loughran Sinéad T., Phelan Susan, Smith Sinéad M., D'Souza Brendan N., Tierney Rosemary J., Bell Andrew I., Cahill Paul A., Walls Dermot, Longnecker R. M., Repression of the Proapoptotic Cellular BIK/NBK Gene by Epstein-Barr Virus Antagonizes Transforming Growth Factor β1-Induced B-Cell Apoptosis , Journal of Virology, 88, 9, 2014. Crossref
-
Wang Huabo, Dolezal James M., Kulkarni Sucheta, Lu Jie, Mandel Jordan, Jackson Laura E., Alencastro Frances, Duncan Andrew W., Prochownik Edward V., Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice, Journal of Biological Chemistry, 293, 38, 2018. Crossref