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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Eosinophils in Homeostasis and Their Contrasting Roles during Inflammation and Helminth Infections

Volume 36, Issue 3, 2016, pp. 193-238
DOI: 10.1615/CritRevImmunol.2016018726
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ABSTRACT

Eosinophil numbers are highly elevated during helminth infections and a range of allergic and inflammatory disorders, but eosinophils are also present in several tissues in the absence of infection. Indeed, new findings demonstrate that eosinophils may be involved in events as diverse as glucose metabolism, mammary gland development, intestinal health, tissue remodeling, thymic selection, and B-cell survival. Although eosinophils often correlate with pathological parameters during conditions such as inflammatory bowel disease and asthma, the evidence for their contribution to tissue pathology remains controversial. Recent research suggests that eosinophils may have additional roles in these settings that are related to control and resolution of inflammation. Controversy also surrounds the involvement of eosinophils in anti-helminth immunity. Their assumed role in fighting parasites has increasingly been questioned, particularly as a result of data from studies of eosinophil-ablated mouse strains in which either no or only very moderate effects on helminth survival has been reported. Helminths are masters of immune regulation, but whether they actively suppress eosinophil function has rarely been considered. Thus, the purpose of this review is threefold: (1) to summarize our knowledge of the wide range of functions of eosinophils during homeostasis, (2) to discuss the role of eosinophil during inflammation and the recent discovery of eosinophils as mediators of inflammatory resolution, and (3) to summarize data on the effect of eosinophils on helminth infections and discuss the possibility of helminth-mediated modulation of eosinophils.

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  9. Conceição-Silva Fátima, Reis Clarissa S. M., De Luca Paula Mello, Leite-Silva Jessica, Santiago Marta A., Morrot Alexandre, Morgado Fernanda N., The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection, Cells, 10, 8, 2021. Crossref

  10. González Marisol I., Lopes Fernando, McKay Derek M., Reyes José L., Mast cell deficiency in mice results in biomass overgrowth and delayed expulsion of the rat tapeworm Hymenolepis diminuta , Bioscience Reports, 38, 6, 2018. Crossref

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  17. Aravindhan Vivekanandhan, Joy Manohar Sibi, Helminth Induced Immunomodulation against Metainflammation and Insulin Resistance, in Inflammation in the 21st Century, 2022. Crossref

  18. Lombardi Carlo, Berti Alvise, Cottini Marcello, The emerging roles of eosinophils: Implications for the targeted treatment of eosinophilic-associated inflammatory conditions, Current Research in Immunology, 3, 2022. Crossref

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