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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Role of Innate Immunity in Transplantation Tolerance

Volume 28, Issue 5, 2008, pp. 403-439
DOI: 10.1615/CritRevImmunol.v28.i5.30
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ABSTRACT

Allogeneic organ transplantation has proven to be an effective therapeutic strategy for patients with end-stage organ disease. However, the chronic immunosuppression that is required for the survival of the allograft increases the risk for infection and malignancy. The establishment of transplantation tolerance, defined functionally as the survival of a donor allograft in the absence of immunosuppression, is the ultimate goal in the field of transplantation. Transplantation tolerance can be achieved using approaches that induce peripheral and/or central tolerance to the allograft. Protocols based on costimulation blockade (CB) have emerged as some of the most promising protocols for inducing long-term allograft survival in the absence of chronic immunosuppression. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation, which activate Toll-like receptors (TLR). In this review, we discuss how the activation of TLRs can affect the induction and maintenance of transplantation tolerance.

CITED BY
  1. Priyadharshini Bhavana, Thornley Thomas B., Daniels Keith A., Cuthbert Amy, Welsh Raymond M., Greiner Dale L., Brehm Michael A., Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death, Immunology, 138, 4, 2013. Crossref

  2. Berman Jules J., Diseases of Immunity, in Rare Diseases and Orphan Drugs, 2014. Crossref

  3. Rules, Some of Which are Always True, and All of Which are Sometimes True, in Rare Diseases and Orphan Drugs, 2014. Crossref

  4. Gill R. G., Just How Stable Is Allograft Tolerance?, American Journal of Transplantation, 10, 7, 2010. Crossref

  5. Priyadharshini Bhavana, Greiner Dale L., Brehm Michael A., T-cell activation and transplantation tolerance, Transplantation Reviews, 26, 3, 2012. Crossref

  6. Wang Hongjun, Wu Hongju, Rocuts Fredy, Gu Zhuoying, Bach Fritz H., Otterbein Leo E., Activation of Peroxisome Proliferator-Activated Receptor γ Prolongs Islet Allograft Survival, Cell Transplantation, 21, 10, 2012. Crossref

  7. Li Chao, Zhang Li-Min, Zhang Xue, Huang Xia, Liu Yong, Li Ming-Qiang, Xing Shuai, Yang Tao, Xie Lin, Jiang Feng-Chao, Jiang Han-Ying, He Wen-Tao, Zhou Ping, Short-term Pharmacological Inhibition of MyD88 Homodimerization by a Novel Inhibitor Promotes Robust Allograft Tolerance in Mouse Cardiac and Skin Transplantation, Transplantation, 101, 2, 2017. Crossref

  8. FrancoSalinas Gabriela, Mai Hoa-Le, Jovanovic Voja, Moizant Frédérique, Vanhove Bernard, Boeffard Francoise, Usal Claire, Tak Paul P., Soulillou Jean-Paul, Baeten Dominique, Brouard Sophie, TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model, Journal of Leukocyte Biology, 90, 2, 2011. Crossref

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