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Critical Reviews™ in Immunology

Impact factor: 3.698

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v29.i2.30
pages 131-154

Viral Mechanisms Involved in the Transcriptional CBP/р300 Regulation of Inflammatory and Immune Responses

Yolanda Revilla
Centro de Biologia Molecular "Severo Ochoa," (CSIC-UAM) Universidad Autonoma de Madrid, 28049 Madrid, Spain
Aitor G. Granja
Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

ABSTRACT

The transcriptional coactivators CREB-binding protein (СВР) and р300 regulate inducible transcription in multiple cellular processes and during the establishment of inflammatory and immune response. These closely related transcriptional coactivators arc able to modulate the transcription of specific genes, modify chromatin structure, and influence cell-cycle progression. Several viruses have been shown to interfere with CREB-binding protein/р300 function, modulating their transcriptional activity. During a viral infection, reprogramming of the host cell gene expression pattern is required to establish an adequate antiviral response and, thus, many viruses encode proteins that can influence or interfere with cellular signals to evade inflammation and immune response. The mechanism of transcriptional regulation by coactivator proteins, including р300/CBP, has been the focus of intense study. As a part of this, some of the molecular instruments developed by viruses to counteract the host response and their role in the regulation of inflammation and immune response are summarized in this review.

KEY WORDS: CBP/p300, NF-κ, В, , NFAT, COX-2, TNF-α, , iNOS, A238L