Published 4 issues per year
ISSN Print: 1050-6934
ISSN Online: 1940-4379
Indexed in
Anterior Cruciate Reconstruction with Bioactive Leeds-Keio Ligament (LKII): Preliminary Report
ABSTRACT
The scaffold type Leeds-Keio artificial ligament (LK) for ligament reconstruction of the knee provides sufficient strength to require minimal sacrifice of autogenous tissue. This implant works not only as prosthesis but also as scaffold onto which natural tissue grows from the synovium. LK has been in clinical use for anterior cruciate ligament (ACL) reconstruction since 1982, although the operative procedure has been modified and has undergone significant development since that time. Recently, we developed radio frequency-generated glow discharge (RFGGD)-treated LK ligament (LKII, previously indicated as Bio-LK) to improve tissue induction and reported that cell proliferation and cell attachment to artificial fibers increased considerably with this hydrophilic treatment. In this study, we report the findings of reconstructed ACL using LKII, which has been in clinical use since 2003. At reconstruction, LKII was covered with the remnant of the original ACL as much as possible in order to preserve the nerve ending system. Thirteen cases with over 12 months' postoperative history were reviewed. Knee stability was regained after reconstruction without any complications such as joint effusion and chronic synovitis. In one case, postoperative arthroscopy showed that the reconstructed ACL was completely covered with newly formed tissue at 8 weeks postoperatively. Biopsy revealed abundant fibroblasts, collagenous fibers, and vessels around the artificial fibers without marked inflammatory findings. Transmission electron microscope study showed abundant thin collagen fibers, which demonstrated regular orientation to some extent. Fibroblasts were observed with extensive amount of rough endoplasmic reticulum. According to these results, we consider LKII to be superior to LK in tissue induction and maturation.
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Chen Jimin, Xu Jiake, Wang Allan, Zheng Minghao, Scaffolds for tendon and ligament repair: review of the efficacy of commercial products, Expert Review of Medical Devices, 6, 1, 2009. Crossref
-
Messenger Michael P., Raïf El M., Seedhom Bahaa B., Brookes Steven J., Enamel matrix derivative enhances tissue formation around scaffolds used for tissue engineering of ligaments, Journal of Tissue Engineering and Regenerative Medicine, 4, 2, 2010. Crossref
-
Laflamme M., Lamontagne J., Guidoin R., Anterior cruciate ligament prostheses using biotextiles, in Biotextiles as Medical Implants, 2013. Crossref
-
Laflamme M., Lamontagne J., Guidoin R., Anterior cruciate ligament prostheses using biotextiles☆, in Biomedical Textiles for Orthopaedic and Surgical Applications, 2015. Crossref
-
Batty Lachlan M., Norsworthy Cameron J., Lash Nicholas J., Wasiak Jason, Richmond Anneka K., Feller Julian A., Synthetic Devices for Reconstructive Surgery of the Cruciate Ligaments: A Systematic Review, Arthroscopy: The Journal of Arthroscopic & Related Surgery, 31, 5, 2015. Crossref
-
Chen Tianwu, Jiang Jia, Chen Shiyi, Status and headway of the clinical application of artificial ligaments, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2, 1, 2015. Crossref
-
Altman Gregory H., Horan Rebecca L., Weitzel Paul, Richmond John C., The Use of Long-term Bioresorbable Scaffolds for Anterior Cruciate Ligament Repair, Journal of the American Academy of Orthopaedic Surgeons, 16, 4, 2008. Crossref
-
Triantafyllopoulos Ioannis K., Lampropoulou-Adamidou Kalliopi, Schizas Nikitas P., Karadimas Eleftherios V., Surgical treatment of acute type V acromioclavicular joint dislocations in professional athletes: an anatomic ligament reconstruction with synthetic implant augmentation, Journal of Shoulder and Elbow Surgery, 26, 12, 2017. Crossref
-
Elveos Marlene Mauseth, Drogset Jon Olav, Engebretsen Lars, Brønn Raymond, Lundemo Trond Olav, Gifstad Tone, Anterior Cruciate Ligament Reconstruction Using a Bone–Patellar Tendon–Bone Graft With and Without a Ligament Augmentation Device: A 25-Year Follow-up of a Prospective Randomized Controlled Trial, Orthopaedic Journal of Sports Medicine, 6, 11, 2018. Crossref
-
Abdullah Shalimar, Mohtar Fadzlina, Abdul Shukor Nordashima, Sapuan Jamari, In Vitro Evaluation of Human Hand Tendon Ingrowth into A Synthetic Scaffold, The Journal of Hand Surgery (Asian-Pacific Volume), 22, 04, 2017. Crossref
-
Abdullah Shalimar, Gill Narin Singh Parminder Singh, Zi Fan Elaine Soh, Ahmad Amir Adham, Mohd Haflah Nor Hazla, Sapuan Jamari, Long-Term Follow-Up of Synthetic Ligament (Orthotape) Usage in Reconstructive Surgery of the Hand, Journal of Hand Surgery Global Online, 3, 4, 2021. Crossref
-
Martin Robin, Nyland John, Jakob Roland Peter, ACL surgical innovation cycles: what goes around, comes around, Journal of ISAKOS, 5, 6, 2020. Crossref
-
丁 浩, Application Progress of Artificial Ligament in Ligament Reconstruction of Knee Joint, Advances in Clinical Medicine, 12, 08, 2022. Crossref