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Journal of Long-Term Effects of Medical Implants

Published 4 issues per year

ISSN Print: 1050-6934

ISSN Online: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

Indexed in

Joint Replacement Surgery and the Innate Immune System

Volume 24, Issue 4, 2014, pp. 253-257
DOI: 10.1615/JLongTermEffMedImplants.2014010627
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ABSTRACT

Total joint replacement is a highly successful, cost-effective surgical procedure that relieves pain and improves function for patients with end-stage arthritis. The most commonly used materials for modern joint replacements include metal alloys such as cobalt chrome and titanium alloys, polymers including polymethylmethacrylate and polyethylene, and ceramics. Implantation of a joint prosthesis incites an acute inflammatory reaction that is regulated by the innate immune system, a preprogrammed non-antigen specific biological response composed of cells, proteins, and other factors. This "frontline" immune mechanism was originally designed to combat invading microorganisms, but now responds to both pathogen-associated molecular patterns or PAMPS (by-products from microorganisms), and damage associated molecular patterns or DAMPS (molecular by-products from cells), via pattern recognition receptors (PRRs). In this way, potentially injurious stimuli that might disrupt the normal homeostatic regulatory mechanisms of the organism are efficiently dealt with, ensuring the survival of the host. Initial surgical implantation of the joint replacement, as well as ongoing generation of wear debris and byproducts during usage of the joint, activates the innate immune system. Understanding and potentially modulating these events may lead to improved function and increased longevity of joint replacements in the future.

CITED BY
  1. Plekhova Natalia G., Lyapun Irina N., Shumatov Valentin B., Gnedenkov Sergey V., Sinebryukhov Sergey L., Puz’ Artem V., Pustovalov Evgenii V., Responses of Dendritic Cells to Different Coatings of Titanium, in 3rd International Multidisciplinary Microscopy and Microanalysis Congress (InterM), 186, 2017. Crossref

  2. Rouabhia Mahmoud, Mighri Nabila, Mao Jifu, Park Hyun Jin, Mighri Frej, Ajji Abdallah, Zhang Ze, Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation, The Canadian Journal of Chemical Engineering, 96, 10, 2018. Crossref

  3. Salehi Ghazaleh, Behnamghader Aliasghar, Mozafari Masoud, Cellular response to metal implants, in Handbook of Biomaterials Biocompatibility, 2020. Crossref

  4. Revell Peter A., Biological causes of prosthetic joint failure, in Joint Replacement Technology, 2021. Crossref

  5. Higuera-Rueda Carlos A., Emara Ahmed K., Nieves-Malloure Yeni, Klika Alison K., Cooper Herbert J., Cross Michael B., Guild George N., Nam Denis, Nett Michael P., Scuderi Giles R., Cushner Fred D., Piuzzi Nicolas S., Silverman Ronald P., The Effectiveness of Closed-Incision Negative-Pressure Therapy Versus Silver-Impregnated Dressings in Mitigating Surgical Site Complications in High-Risk Patients After Revision Knee Arthroplasty: The PROMISES Randomized Controlled Trial, The Journal of Arthroplasty, 36, 7, 2021. Crossref

  6. Kim Christopher, Keating Armand, Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells, Gerontology, 65, 3, 2019. Crossref

  7. Chen Lan, Wang Donghui, Qiu Jiajun, Zhang Xianming, Liu Xingdan, Qiao Yuqin, Liu Xuanyong, Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface, Bioactive Materials, 6, 1, 2021. Crossref

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