Published 4 issues per year
ISSN Print: 1050-6934
ISSN Online: 1940-4379
Indexed in
Stem Cells: A New Paradigm in Medical Therapeutics
ABSTRACT
Even though the stem cells have been studied for decades, only during the past few years has there been an overwhelming proliferation of publications covering isolation, cultivation and utilization of the body's master cells. This paper attempts to summarize the recent studies in the field of stem cells. A number of studies have reported the existence of multipotent stem cells in the cord, cord blood, placenta, bone marrow, brain, heart, teeth, skin, liver, hair follicles and many other tissues and organs, giving rise to cell types other than their tissue of origin. Increased therapeutic use of stem cells has resulted in scientific methods of collection, testing, processing and storage of these cells, with minimal cell damage and differentiation. Cell expansion, bioreactors and tissue engineering are employed extensively to improve the cell dose and outcome. Stem cell infusion, transplantation and implantation are accepted curative therapies for many malignant and non-malignant conditions. Stem cell therapies also provide alternative solutions for the repair and regeneration of various tissues and organs. There has been a dramatic improvement in the understanding of immunosuppressive properties of stem cells on various immune cell types. Stem cells are found to secrete angiogenic cytokines that increase neovascularization. They bring the promise of curing a disease state as these cells normally regenerate tissues in a healthy organism. Stem cell transplantation, in isolation or in combination with other procedures, has been found to be effective. Stem cell therapy is also seen as a possible alternative for the treatment of different diseases such as juvenile diabetes, amyotrophic lateral sclerosis, cerebral palsy, stroke, spinal cord injury and Parkinson's disease. Regenerative medicine using human stem cells is one of the new and promising fields for treating various intractable diseases and damaged organs.
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Arivazhagan Arivarasan, Krishna Soni, Yadav Shivangi, Shah Harshit Rajesh, Kumar Pravir, Ambasta Rashmi Kumar, Synergy of bone marrow transplantation and curcumin ensue protective effects at early onset of diabetes in mice 在早期发病的糖尿病小鼠中使用骨髓移植和姜黄素联合治疗具有协同保护作用, Journal of Diabetes, 7, 4, 2015. Crossref
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Meier Carola, Rosenkranz Katja, Cx43 expression and function in the nervous system—implications for stem cell mediated regeneration, Frontiers in Physiology, 5, 2014. Crossref
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Holmes Benjamin, Fang Xiuqi, Zarate Annais, Keidar Michael, Zhang Lijie Grace, Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials, Carbon, 97, 2016. Crossref
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Nguyen Hal X., Cramer Steven C., Cell-Based Therapies for the Treatment of Aphasia, in Neurobiology of Language, 2016. Crossref
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Shabbir Arsalan, Badiavas Evangelos V, Toward an ‘off the shelf’ technology for burn victims: healing wounds with mesenchymal stem cells, Regenerative Medicine, 10, 4, 2015. Crossref