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Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and Snail

Volume 3, Issue 2, 2012, pp. 125-133
DOI: 10.1615/ForumImmunDisTher.2012006065
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ABSTRACT

Treatment of cancer cell lines with high levels of nitric oxide (NO) via NO donors, such as DETANONOate, inhibits cell growth and survival pathways and sensitizes resistant tumor cells to apoptosis by chemoimmunotherapeutic drugs. In addition, we recently have reported that NO also inhibits the epithelial-to-mesenchymal transition (EMT) phenotype in metastatic cancer cell lines via dysregulation of the nuclear factor (NF)-κB/Snail/Yin Yang 1 (YY1)/Raf kinase inhibitor protein circuitry. The mechanism underlying NO-mediated dysregulation of this circuit was investigated, namely, NO-mediated inhibition of the activity of the transcription factors NF-κB, Snail, and YY1. We hypothesized that one mechanism of NO-mediated inhibition may invoke the NO-induced S-nitrosylation of these transcription factors. We demonstrate in metastatic and EMT+ human prostate carcinoma cell lines that treatment with NO results in the S-nitrosylation of NF-κB (p50), Snail, and YY1 and inhibits their activities, resulting in the reversal of the EMT phenotype into a mesenchymal -to-epithelial transition phenotype. These findings suggest that NO donors may be potential therapeutic agents in both the reversal of resistance and the inhibition of EMT and metastasis.

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  1. Raman Deepika, Foo Chuan Han Jonathan, Clement Marie-Veronique, Pervaiz Shazib, Breast Cancer: A Molecular and Redox Snapshot, Antioxidants & Redox Signaling, 25, 6, 2016. Crossref

  2. Kielbik Michal, Szulc-Kielbik Izabela, Nowak Marek, Sulowska Zofia, Klink Magdalena, Evaluation of nitric oxide donors impact on cisplatin resistance in various ovarian cancer cell lines, Toxicology in Vitro, 36, 2016. Crossref

  3. Atlante Sandra, Chegaev Konstantin, Cencioni Chiara, Guglielmo Stefano, Marini Elisabetta, Borretto Emily, Gaetano Carlo, Fruttero Roberta, Spallotta Francesco, Lazzarato Loretta, Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors, European Journal of Medicinal Chemistry, 144, 2018. Crossref

  4. Bettaieb Ali, Paul Catherine, Plenchette Stéphanie, Exploration of Fas S-Nitrosylation by the Biotin Switch Assay, in CD95, 1557, 2017. Crossref

  5. Du Lei, Tang Jun-Hai, Huang Guo-Hao, Xiang Yan, Lv Sheng-Qing, The progression of epithelial-mesenchymal transformation in gliomas, Chinese Neurosurgical Journal, 3, 1, 2017. Crossref

  6. Du Wen-Liang, Fang Qian, Chen Yue, Teng Jing-Wei, Xiao Yong-Shuang, Xie Ping, Jin Bo, Wang Jun-Qi, Effect of silencing the T-Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells, Molecular Medicine Reports, 16, 5, 2017. Crossref

  7. Bonavida Benjamin, Pivotal Role of Nitric Oxide in Chemo and Immuno Sensitization of Resistant Tumor Cells to Apoptosis, in Nitric Oxide and Cancer: Pathogenesis and Therapy, 2015. Crossref

  8. Korde Choudhari Sheetal, Chaudhary Minal, Bagde Sachin, Gadbail Amol R, Joshi Vaishali, Nitric oxide and cancer: a review, World Journal of Surgical Oncology, 11, 1, 2013. Crossref

  9. Khan Faizan H., Dervan Eoin, Bhattacharyya Dibyangana D., McAuliffe Jake D., Miranda Katrina M., Glynn Sharon A., The Role of Nitric Oxide in Cancer: Master Regulator or NOt?, International Journal of Molecular Sciences, 21, 24, 2020. Crossref

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  17. Liang Sitai, Yadav Mukesh, Vogel Kristine S., Habib Samy L., A novel role of snail in regulating tuberin/AMPK pathways to promote renal fibrosis in the new mouse model of type II diabetes, FASEB BioAdvances, 3, 9, 2021. Crossref

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