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Nanoscience and Technology: An International Journal
ESCI SJR: 1.031 SNIP: 1.517 CiteScore™: 0.7

ISSN Print: 2572-4258
ISSN Online: 2572-4266

Nanoscience and Technology: An International Journal

Formerly Known as Nanomechanics Science and Technology: An International Journal

DOI: 10.1615/NanomechanicsSciTechnolIntJ.v7.i2.50
pages 165-175

BIOSAFETY AND EFFECT OF NANOPARTICLES OF CeO2 ON METABOLIC AND PROLIFERATIVE ACTIVITY OF HUMAN MESENCHYMAL STEM CELLS IN VITRO

A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
A. M. Ermakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
I. V. Savintseva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
I. I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
R. A. Poltavtseva
Federal State Budgetary Institution "Academician V. I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia
E. I. Zaraisky
Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, Russia
A. M. Poltavtsev
Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, Russia
I. E. Stepanova
Research Institute of Human Morphology, Moscow, Russia
V. K. Ivanov
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
G. T. Sukhikh
Federal State Budget Institution "Academician V. I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology," Russian Ministry of Health, Moscow, Russia

ABSTRACT

Clinical use of mesenchymal stem cells (MSCs) provides new prospects for treatment of most socially significant human diseases. Meanwhile, today there exist certain restrictions and difficulties in using MSCs for biomedical purposes. One of the restrictions for broad application of MSCs in cell therapy is their low proliferation rate in vitro, which increases the patient's waiting time for such treatment and, ultimately, its cost. Therefore, the search for new efficient and safe stimulators of MSC proliferation represents an urgent problem. In this work, we investigated the effect of cerium oxide (CeO2) nanoparticles on proliferative activity of human MSCs derived from human dental pulp. It was demonstrated that CeO2 nanoparticles are not toxic for human MSCs and increase their proliferation rate in vitro, simulating the level of expression of a broad range of genes responsible for the processes of proliferation, differentiation, and the cell cycle.


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