Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
Indexed in
Hemolytic Potential of Structurally Related Aniline Halogenated Hydroxylamines
ABSTRACT
This study was undertaken to investigate the hemolytic potential of several structurally related aniline halogenated phenylhydroxylamines based on their decreasing electro negativity. The compounds compared are phenylhydroxylamine (PHA) and para-fluoro-, para-bromo-, and para-iodo-phenylhydroxylamines. Red blood cells of male Sprague-Dawley rats were labeled with radioactive chromium-51 and exposed to the test agent before being infused into the tail vein of isologous rats. The time course of blood radioactivity was monitored. The stability of some selected halogenated aniline analogs was also determined in blood. All four tested hydroxylamines produced dose-dependent reduction in the circulating labeled red blood cells indicating their destruction and loss. The most pronounced reduction was observed at doses from 175 to 250 μM. The dose of 100 μM appeared to be the threshold limit. The para-iodo-PHA was two times more toxic than para-fluoro-PHA in the destruction of red blood cells in rats.
-
Singh Harpal, Purnell Elissa, Smith Carion, Mechanistic Study on Aniline-Induced Erythrocyte Toxicity, Archives of Industrial Hygiene and Toxicology, 58, 3, 2007. Crossref
-
Vickers Alison E.M., Sinclair John R., Fisher Robyn L., Morris Stephen R., Way William, Blood cell oxidative stress precedes hemolysis in whole blood–liver slice co-cultures of rat, dog, and human tissues, Toxicology and Applied Pharmacology, 244, 3, 2010. Crossref
-
Anilin [MAK Value Documentation in German language, 2007], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref
-
Aniline [MAK Value Documentation, 2010b], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref
-
Asai Takaho, Takeshita Jun-ichi, Shimizu Yuki, Tochikubo Yoshihiro, Shizu Ryota, Hosaka Takuomi, Kanno Yuichiro, Yoshinari Kouichi, Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model, Food and Chemical Toxicology, 157, 2021. Crossref
-
Otieno Monicah A., Lehman-McKeeman Lois D., Mechanism-based toxicity studies for drug development, in Predictive Toxicology in Drug Safety, 2010. Crossref