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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Jaggery Protects Hepatorenal Injury Induced by Acute Exposure to Carbon Tetrachloride in Wistar rats

Volume 32, Issue 1, 2013, pp. 1-7
DOI: 10.1615/JEnvironPatholToxicolOncol.2013006793
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ABSTRACT

In this study, we evaluated the protective activity of aqueous extract of jaggery against CCl4-induced hepatic−renal damage in rats. Jaggery was administered in one group at doses of 250, 500 and 750 mg/ kg body weight (bwt) (p.o., once only), and CCL4 was administered in another group at a dose of 1.5 ml/kg bwt (i.p., once only) to evaluate the protective effect of jaggery on induced oxidative damage in rats. Various blood and tissue biochemical studies were performed. The administration of toxicant significantly altered blood biochemical variables. Hepatic and renal lipid peroxidation (LPO) levels increased significantly, whereas considerable depletion was observed in reduced glutathione (GSH) level after intoxication. A remarkable decrease was observed in the activities of adenosine triphosphatase (ATPase) and glucose-6-phosphatase (G-6-Pase) after induction of toxicity. Treatment with extract at three different altered all measured biochemical variables, but greater hepatic-renal protection was observed at higher doses (750 mg/kg bwt) than at lower does (250 and 500 mg/kg bwt). Jaggery also reversed histopathological alterations. Thus, it may be concluded that jaggery can be used to reduce hepatic and renal damage and may serve as an alternative medicine in hepatic and renal etiology.

CITED BY
  1. Shafie Nurul Husna, Mohd Esa Norhaizan, Ithnin Hairuszah, Md Akim Abdah, Saad Norazalina, Pandurangan Ashok Kumar, Preventive Inositol Hexaphosphate Extracted from Rice Bran Inhibits Colorectal Cancer through Involvement of Wnt/β-Catenin and COX-2 Pathways, BioMed Research International, 2013, 2013. Crossref

  2. Sharma Monika, Yadav Ishita, Sharma Chandra K., Applications of Different Biomarkers in the Diagnosis of Drug-induced Liver Injury, The Open Biomarkers Journal, 9, 1, 2019. Crossref

  3. Solís-Fuentes Julio Alberto, Hernández-Ceja Yessica, Hernández-Medel María del Rosario, García-Gómez Rolando S., Bernal-González Marisela, Mendoza-Pérez Samuel, Durán-Domínguez-de-Bazúa María del Carmen, Quality improvement of jaggery, a traditional sweetener, using bagasse activated carbon, Food Bioscience, 32, 2019. Crossref

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